A5086577802- Health and Wellbeing Research
- Diverse Approaches in Healthcare and Education Studies
- Immune cells in cancer
- Exercise and Physiological Responses
- Psychological Well-being and Life Satisfaction
- Nitric Oxide and Endothelin Effects
- Innovations in Medical Education
- Angiogenesis and VEGF in Cancer
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Simulation-Based Education in Healthcare
- Health disparities and outcomes
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Healthcare Systems and Reforms
- Cancer-related molecular mechanisms research
- Education and Learning Interventions
- Recreation, Leisure, Wilderness Management
- Health and Well-being Studies
- Physical Activity and Education Research
- Education and Critical Thinking Development
- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- MicroRNA in disease regulation
- Cancer-related gene regulation
Ewha Womans University
2020-2021
University of California, Los Angeles
2017
Korea University
2012-2014
Ajou University
2012
Seoul National University
2000-2002
Inflammation and inflammatory mediators are inextricably linked with epithelial-mesenchymal transition (EMT) through complex pathways in the tumor microenvironment. However, mechanism by which mediators, such as lipid eicosanoids, contribute to EMT is largely unknown. In present study we observed that BLT2, leukotriene B4 receptor-2, markedly up-regulated oncogenic Ras promotes response transforming growth factor-β (TGF-β) mammary epithelial cells. Blockade of BLT2 inhibitor LY255283 or...
Background The elevated production of interleukin (IL)–8 is critically associated with invasiveness and metastatic potential in breast cancer cells. However, the intracellular signaling pathway responsible for up-regulation IL-8 cells has remained unclear. Methodology/Principal Findings In this study, we report that expression BLT2 markedly up-regulated highly aggressive human cell lines MDA-MB-231 MDA-MB-435 compared MCF-10A immortalized mammary epithelial cells, as determined by RT-PCR,...
The prenatal period of cortical development is important for the establishment neural circuitry and functional connectivity brain; however, molecular mechanisms underlying this process remain unclear. Here we report that disruption actin-cytoskeletal network in developing mouse prefrontal cortex alters dendritic morphogenesis synapse formation, leading to enhanced formation fear-related memory adulthood. These effects are mediated by a brain-enriched microRNA, miR-9, through its negative...
The purpose of this study was to determine factors that influence the unmet healthcare needs older women in Korea and examine differences reasons for these according age residential area. We analyzed data from 2018 Community Health Survey enrolled 42,698 Korean study. Residential area, living arrangement, income, education, basic livelihood subsidy, activity daily living, subjective health status, hypertension diabetes, needs, were not met assessed. Logistic regression analysis performed...
The purpose of the current study was to investigate relationships among leisure competence, level activity, and life satisfaction in low-income older adults rural South Korea. A sample 137 answered questionnaire, significant differences competence were noted depending on age, religion, perceived health status as well activity based type activities. There also notable regarding religion status, a correlation satisfaction; influencing power 47%. findings suggest that enhancement adults' may...
The study aimed to evaluate the effectiveness of a cervical cancer prevention education program for rural Korean immigrant women. A total 46 women who had not been screened in past three years participated. experimental group participated intervention once week four weeks and completed post-program survey 12. Compared control group, significant increases were detected level knowledge (p = .001), behavioral attitude toward .029) intention regarding .005) group. Pap screening rate was...
Abstract Invasion of cancer cells depends on the proteolytic degradation extracellular matrix and it is initiated by actin-driven membrane protrusions, called invadopodia. However, mechanisms underlying invadopodia formation remain largely unknown. In this study, we report that TIS21/BTG2/PC3, tumor suppressor gene, suppress in highly invasive breast cells, MDA-MB-231. To understand downstream regulating TIS21, generation ROS (reactive oxygen species) NADPH oxidase (Nox) was examined...