A5101445103- Ferroptosis and cancer prognosis
- Single-cell and spatial transcriptomics
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Flavonoids in Medical Research
- Natural product bioactivities and synthesis
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Pharmacological Effects of Natural Compounds
- Gene expression and cancer classification
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
China Pharmaceutical University
2023-2025
ABSTRACT Viral infections contribute to a higher incidence of cancer than any other individual risk factor. This study aimed compare the clinical and molecular features four viral‐associated cancers: stomach adenocarcinoma (STAD), head neck squamous cell carcinoma (HNSC), liver hepatocellular (LIHC), cervical (CESC). Patients were categorized based on viral infection status, as provided in data, into virus‐associated non‐virus‐associated groups, followed by comprehensive comparison features....
Wound healing is a meticulously coordinated and intricate progression that necessitates precise regulation of fibroblast behavior. Macroautophagy/autophagy degradation system for clearing damaged cellular components. SQSTM1/p62 (sequestosome 1), well-established autophagy receptor, also functions as signaling hub beyond autophagy. Here, we observed significant upregulation in fibroblasts after wounding. Using mice with fibroblast-specific deletion Atg7 (autophagy related 7), found governed...
Non-small cell lung cancer (NSCLC) accounts for 85% of all cancers, the leading cause cancer-related deaths worldwide. Despite recent advancements in NSCLC treatment, such as targeted therapy and immunotherapy, a large proportion patients develop drug resistance. Thus, development new effective treatments is urgently needed. Traditional Chinese medicine may provide sources developing anti-cancer drugs. Although Scutellaria baicalensis (SB) has been proven to have effects, its action...
Abstract The clinical adoption of small interfering RNAs (siRNAs) has prompted the development various computational strategies for siRNA design, from traditional data analysis to advanced machine learning techniques. However, previous studies have inadequately considered full complexity silencing mechanism, neglecting critical elements such as positioning on mRNA, RNA base-pairing probabilities, and RNA-AGO2 interactions, thereby limiting insight accuracy existing models. Here, we introduce...
Abstract The clinical adoption of small interfering RNAs (siRNAs) has prompted the development various computational strategies for siRNA design, from traditional data analysis to advanced machine learning techniques. However, previous studies have inadequately considered full complexity silencing mechanism, neglecting critical elements such as positioning on mRNA, RNA base-pairing probabilities, and RNA–AGO2 interactions, thereby limiting insight accuracy existing models. Here, we introduce...