A5042044859- Cerebrospinal fluid and hydrocephalus
- Atherosclerosis and Cardiovascular Diseases
- Tracheal and airway disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Genomics and Diagnostics
- COVID-19 and healthcare impacts
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Head and Neck Anomalies
- Optical Imaging and Spectroscopy Techniques
- Fetal and Pediatric Neurological Disorders
- Advanced MRI Techniques and Applications
- Protease and Inhibitor Mechanisms
- Neonatal and fetal brain pathology
- Surgical site infection prevention
- Cerebrovascular and Carotid Artery Diseases
- Respiratory Support and Mechanisms
- Neurosurgical Procedures and Complications
- Mycobacterium research and diagnosis
- Respiratory and Cough-Related Research
- Chemokine receptors and signaling
- Science, Research, and Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Enhanced Recovery After Surgery
Imperial College Healthcare NHS Trust
2022
Institut de Virologie
2021
St George's Hospital
2020
Institute of Cancer Research
2018
University Hospital Lewisham
2017
Guy's and St Thomas' NHS Foundation Trust
2016-2017
Royal Marsden Hospital
2017
Evelina London Children's Healthcare
2017
Charing Cross Hospital
2010-2016
Imperial College London
2010-2016
OBJECTIVES Lymphoma often presents with a neck mass and while fine-needle aspiration cytology may be suggestive, tissue biopsy is required for reliable diagnosis classification of lymphoma that sufficient to deliver the correct treatment patient. Traditionally, excisional lymph node has been standard method sampling, providing ample assessment. However, this requires theatre time, preceding cytology, which incur delay. With careful use tissue, coupled advances in immunohistochemical...
Objectives Intracapsular tonsillectomy (tonsillotomy) has been used internationally, mainly in the management of obstructive sleep apnoea, rather than recurrent tonsillitis, with few published data evaluating its use for this latter indication. We present long‐term prospective from 500 paediatric cases undergoing Coblation ® intracapsular tonsillectomy, both and infective indications. Design Prospective case series, March 2013‐January 2016, all completed follow‐up. Setting Tertiary...
Abstract COVIDTrach is a UK multidisciplinary collaborative project that aims to evaluate the outcomes of tracheostomy in COVID-19 patients. An invitation participate an online survey tool (REDCap) was disseminated all NHS departments involved mechanically ventilated Fifty-two percent (n=219/465) patients who had undergone and were still alive, been successfully weaned from mechanical ventilation at point completing survey. The cause in-hospital mortality following 12% (n=62/530), with 3%...
Over a 3-year period, we have performed 312 tests in 197 shunted patients. The data been analyzed retrospectively to: (1) investigate the parameters describing CSF dynamics that correlate with shunt under-drainage and (2) estimate accuracy of this method.Constant rate infusion into prechamber were performed.In 161 tests, results indicated under-draining shunts. Patients group had higher baseline plateau pressures, resistance to outflow levels pulse amplitude waveform. During test,...
Molecular characterisation of vulnerable atherosclerosis is necessary for targeting functional imaging and plaque-stabilising therapeutics. Inflammation has been linked to atherogenesis the development high-risk plaques. We set quantify cytokine, chemokine matrix metalloproteinase (MMP) protein production in cells derived from carotid plaques map inflammatory milieu responsible instability. Carotid endarterectomies carefully characterised symptomatic (n=35) asymptomatic (n=32) patients were...
Abstract Purpose To analyse the complication outcomes of COVID-19 negative patients undergoing elective head and neck surgery during pandemic. Methods This was a retrospective case review all for confirmed or suspected cancer. Results There were no mortalities recorded in cohort analysed. At 30 days, pulmonary complications had occurred 4 (9%). None these related to COVID infection. Conclusion With careful pre-operative screening post-operative care clean ward, can proceed safely epidemic....
Abstract Background Adjustable shunts are very popular in the management of hydrocephalus and believed to help minimizing number surgical revisions. The drawback with almost all constructions is that they may be accidentally readjusted relatively weak magnetic fields (around 30–40 mTesla) Materials methods ProGav Miethke shunt composed an adjustable ballon-spring valve unit integrated over-drainage compensating gravitational device (known as assistant). A mechanical 'brake' intended prevent...
Abstract Background It has been reported that pumping a shunt in situ may precipitate proximal occlusion, and/or lead to ventricular over-drainage, particularly the context of small ventricles. In laboratory we measured effect pre-chamber hydrocephalus shunts on intracranial hypotension. Materials and methods A simple physical model CSF space hydrocephalic patient was constructed with appropriate compliance, production circulation. This used test eleven different shunts. The lowest pressure...
The Sophysa Pressio (Sophysa Ltd., Orsay, France) is a new intracranial pressure monitoring system. This study aimed to evaluate its accuracy and compare it with the popular Codman transducer (Codman/Johnson & Johnson, Raynham, MA) in vitro.A computerized rig was used test transducers simultaneously. Properties that were tested included drift over 7 days, effect of temperature on drift, frequency response, measurement static pulsatile pressures, connectivity system.Long-term (7 d) relative...
The Polaris valve is a newly released hydrocephalus shunt that designed to drain cerebrospinal fluid (CSF) from the brain ventricles or lumbar CSF space. aim of this study was bench test properties shunt, independently manufacturer.The Valve ball-on-spring valve, which can be adjusted magnetically in vivo. A special mechanism incorporated prevent accidental re-adjustment by an external magnetic field. performance and hydrodynamic were evaluated UK Shunt Evaluation Laboratory, Cambridge,...
A 66-year-old woman was transferred to the emergency department with a left-sided neck lump and fever. She stridulous reduced consciousness level required immediate intubation protect her airway. CT imaging showed fluid-filled air-filled lesion in left side of neck; diagnosis later confirmed as an infected laryngocoele. underwent ultrasound guided drainage successful reduction lump. Following elective tracheostomy she weaned from ventilation. Subsequent direct endoscopy biopsy no evidence...
OBJECTIVE The Sophysa Pressio (Sophysa Ltd., Orsay, France) is a new intracranial pressure monitoring system. This study aimed to evaluate its accuracy and compare it with the popular Codman transducer (Codman/Johnson & Johnson, Raynham, MA) in vitro. METHODS A computerized rig was used test transducers simultaneously. Properties that were tested included drift over 7 days, effect of temperature on drift, frequency response, measurement static pulsatile pressures, connectivity RESULTS...
<h3>Rationale</h3> Macrophages in atherosclerotic plaques are a heterogeneous population. To uncover signatures of classical (M1) or alternative (M2) macrophage polarisation during plaque instability, we compared cytokine and chemokine production via Luminex profiling asymptomatic human carotid with the territory recent focal neurological symptomatology. <h3>Methodology</h3> Carotid endarterectomy specimens were collected from 50 consenting patients (26 symptomatic, 24 asymptomatic). Fresh...
A 4-year-old boy presents to your clinic with his mother. Mum tells you that left ear has been discharging for 5 days now and thinks it may be infected. On examining the child’s notice purulent discharge within canal a grommet in-situ. You wonder whether oral or topical antibiotics appropriate in this case. In children tympanostomy tubes ( patient ) develop discharge, are intervention superior systemic comparison when treating otorrhoea outcome )? Please see (online supplementary appendix)...