A5103193224- Adenosine and Purinergic Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Fibroblast Growth Factor Research
- Neuroendocrine Tumor Research Advances
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Mast cells and histamine
- Neurological Complications and Syndromes
- Pregnancy and Medication Impact
- Pharmacological Effects of Natural Compounds
- Cancer-related gene regulation
- Lung Cancer Research Studies
- Inflammatory mediators and NSAID effects
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune and Inflammatory Disorders Research
- Cancer, Hypoxia, and Metabolism
- Biological and pharmacological studies of plants
- Immune Response and Inflammation
- Immune cells in cancer
- Flavonoids in Medical Research
- Circular RNAs in diseases
- Adolescent and Pediatric Healthcare
- Traditional Chinese Medicine Analysis
- Inflammatory Biomarkers in Disease Prognosis
Southwest Medical University
2022-2024
Weifang Medical University
2022-2023
Hangzhou Normal University
2021
Objective: To investigate the effect of Zhilong Huoxue Tongyu capsule (ZLH) in treatment cerebral ischemia–reperfusion injury and determine underlying molecular network mechanism. Methods: The was evaluated for middle artery occlusion (MACO) rat, mechanism explored by using analysis based on pharmacology, bioinformatics including protein–protein interaction (PPI) network, Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), as well docking. Results: neurological function rats ZLH...
The incidence of digestive malignancies has increased in recent years, including colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pancreatic cancer. Advanced stages these cancers are prone to metastasis, which seriously reduce the standard living patients lead decline survival rate patients. So far there no good specific drugs stop this phenomenon. It is very important urgent find new biomarkers therapeutic targets. Purinergic ligand-gated ion channel 7 receptor (P2X7R) ATP-gated...
Abstract To explore the of Qufeng Tongqiao Prescription in treatment cerebral ischemia–reperfusion (CIR) and associated molecular network mechanism. Venny diagram, gene ontology (GO) kyoto encyclopedia genes genomes (KEGG) analysis, protein–protein interaction (PPI), hub mining, docking, combined with animal experiments Nissl stain were performed to determine mechanism for CIR treatment. Fifty three intersecting between ischemia reperfusion acquired from analysis. GO analysis showed that...
To explore the role of P2X7 receptor (P2X7R) in migration and invasion mouse Lewis lung cancer (LLC) cells examine tumorigenic ability LLC P2X7R-knockout mice.RT-PCR was used to P2X7R mRNA expression cells. were treated with ATP (as a agonist) or 2'- 3'- O- (4-benzoyl- benzoyl)-ATP (BzATP) (a without pretreatment antagonist oxATP A438079. The changes invasive abilities evaluated using wound healing assay Transwell assay; Western blotting performed determine activation level key proteins AKT...