A5102922055- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Amyotrophic Lateral Sclerosis Research
- Systemic Lupus Erythematosus Research
- Hematopoietic Stem Cell Transplantation
- Neurogenetic and Muscular Disorders Research
- Myasthenia Gravis and Thymoma
- Nerve injury and regeneration
- Biomedical Ethics and Regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- T-cell and B-cell Immunology
- Parkinson's Disease and Spinal Disorders
- Advanced Neuroimaging Techniques and Applications
- Autoimmune and Inflammatory Disorders Research
- MicroRNA in disease regulation
- Garlic and Onion Studies
- Bone and Joint Diseases
- Polyomavirus and related diseases
- Thyroid and Parathyroid Surgery
- Wound Healing and Treatments
Hadassah Medical Center
2016-2025
Croydon University Hospital
2020
Telio (Norway)
2017
Pasteur Hellenic Institute
2017
Hebrew University of Jerusalem
2011-2016
Hadassah Academic College
2015
<h3>Objective</h3> To evaluate the feasibility, safety, and immunological effects of intrathecal intravenous administration autologous mesenchymal stem cells (MSCs) (also called<i>mesenchymal stromal cells</i>) in patients with multiple sclerosis (MS) amyotrophic lateral (ALS). <h3>Design</h3> A phase 1/2 open-safety clinical trial. <h3>Patients</h3> Fifteen MS (mean [SD] Expanded Disability Status Scale [EDSS] score, 6.7 [1.0]) 19 ALS Amyotrophic Lateral Sclerosis Functional Rating [ALSFRS]...
<h3>Importance</h3> Preclinical studies have shown that neurotrophic growth factors (NTFs) extend the survival of motor neurons in amyotrophic lateral sclerosis (ALS) and combined delivery these has a strong synergistic effect. We developed culture-based method for inducing mesenchymal stem cells (MSCs) to secrete factors. These MSC-NTF been be protective several animal models neurodegenerative diseases. <h3>Objective</h3> To determine safety possible clinical efficacy autologous...
In this study (trial registration: NCT02166021), we aimed to evaluate the optimal way of administration, safety and clinical efficacy mesenchymal stem cell (MSC) transplantation in patients with active progressive multiple sclerosis. Forty-eight (28 males 20 females) sclerosis (Expanded Disability Status Scale: 3.0-6.5, mean : 5.6 ± 0.8, age: 47.5 12.3) evidence either worsening or activity during previous year, were enrolled (between 2015 2018). Patients randomized into three groups treated...
Background: Mesenchymal stem cells (MSC) were shown to possess immunomodulatory and neurotrophic effects. Our previous trials, have that intrathecal (IT) intravenous (IV) administration of MSCs safe provided indications beneficial clinical Methods: This is an open prospective study evaluate the safety long-term immunological effects multiple injections autologous in 24 patients with active-progressive MS. At inclusion, mean age was 47.0 ± 9.22, EDSS score 6.75 0.68 (range: 5.5–7.5). Patients...
Neurofilament light chains (NF-L) were shown to serve as a reliable biomarker of neurodegeneration in multiple sclerosis (MS). The chemokine receptor CXCL13 was correlate with CNS inflammatory activity and predict the future progression MS.To evaluate levels NF-L cerebrospinal fluid (CSF) following treatment mesenchymal stem cells (MSC) patients progressive MS.The CSF samples obtained from 48 MS who participated double-blind randomized phase II clinical trial that tested effects intrathecal...
Background T-cell vaccination (TCV) for multiple sclerosis (MS) refers to treatment with autologous anti-myelin T-cells, attenuated by irradiation. Previously published clinical trials have been all open-labeled. Aim To evaluate the safety and efficacy of TCV in progressive MS, a double-blind, controlled trial. Methodology Twenty-six patients relapsing-progressive MS were enrolled study (mean age: 39±9.8 years; mean EDSS: 4.4±1.7). lines reactive 9 different peptides myelin antigens, MBP,...
Background: Screening of putative autoimmune targets in multiple sclerosis (MS) revealed a proportion patients carrying antibodies (Abs) against KIR4.1, potassium channel that shares functional properties with AQP4. Both are localized at the perivascular astrocytic processes. Aims: To measure anti-KIR4.1 Abs serum MS and neuromyelitis optica (NMO) patients, to identify clinical laboratory characteristics harboring Abs. Methods: We measured serum, using peptide KIR4.1 (83–120) enzyme-linked...
Neuromyelitis optica (NMO) is an idiopathic demyelinating disease of the CNS that can be clearly distinguished from multiple sclerosis (MS) by clinical, neuroradiogic, and pathologic criteria presence highly specific serum autoantibodies against water channel aquaporin-4 (AQP4).1 Although studies support a central role anti-AQP4 antibodies in pathogenesis NMO, their exact involvement immunopathogenetic cascade still not clear, T cells seem to equally crucial for full development clinical...
Zinc and copper are essential metal ions for numerous biological processes. Their levels tightly maintained in all body organs. Impairment of the Zn2+ to Cu2+ ratio serum was found correlate with many disease states, including immunological inflammatory disorders. Oxytocin (OT) is a neuropeptide, its activity modulated by zinc ion binding. Harnessing intrinsic properties OT one attractive ways develop valuable sensors. Here, we report first time an OT-based sensor prepared immobilizing...
In developed countries, multiple sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults. MS a chronic demyelinating disease central nervous system, which myelin attacked, changing white matter structure and leaving lesions. The demyelination has direct effect on conductivity. This can be examined visual where damage highly prevalent MS, to substantial delays conduction, commonly measured with evoked potentials (VEPs). structural system often estimated...
Background: Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent often-presenting symptom disease, well high occurrence rate posterior system damage independent ON (optic radiation lesions), make prime candidate such endeavors. However, while makes convenient model early stages MS, processes which may be true those drastically change disease progresses, due...
Background: Multiple sclerosis (MS) prevalence and genetic susceptibility varies among the different ethnic groups of Jews Arabs in Israel. Objective: Characterization MS disease course Christian, Muslim Druze Methods: Historical cohort three-year follow-up analyses based on interviews clinical charts 149 Arab patients (78 Muslims, 49 Christians 22 Druze) from three centers Significant findings were adjusted for use modifying therapy. Results: Age onset (means between 30 31 years) incomplete...