A5004595505- Mesenchymal stem cell research
- Multiple Sclerosis Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Proteoglycans and glycosaminoglycans research
- Pancreatic function and diabetes
- Garlic and Onion Studies
- Bone and Joint Diseases
- Pomegranate: compositions and health benefits
- Cerebral Palsy and Movement Disorders
- Wound Healing and Treatments
- Glycosylation and Glycoproteins Research
Hadassah Medical Center
2020-2025
Hebrew University of Jerusalem
2015
In this study (trial registration: NCT02166021), we aimed to evaluate the optimal way of administration, safety and clinical efficacy mesenchymal stem cell (MSC) transplantation in patients with active progressive multiple sclerosis. Forty-eight (28 males 20 females) sclerosis (Expanded Disability Status Scale: 3.0-6.5, mean : 5.6 ± 0.8, age: 47.5 12.3) evidence either worsening or activity during previous year, were enrolled (between 2015 2018). Patients randomized into three groups treated...
Background: Mesenchymal stem cells (MSC) were shown to possess immunomodulatory and neurotrophic effects. Our previous trials, have that intrathecal (IT) intravenous (IV) administration of MSCs safe provided indications beneficial clinical Methods: This is an open prospective study evaluate the safety long-term immunological effects multiple injections autologous in 24 patients with active-progressive MS. At inclusion, mean age was 47.0 ± 9.22, EDSS score 6.75 0.68 (range: 5.5–7.5). Patients...
Neurofilament light chains (NF-L) were shown to serve as a reliable biomarker of neurodegeneration in multiple sclerosis (MS). The chemokine receptor CXCL13 was correlate with CNS inflammatory activity and predict the future progression MS.To evaluate levels NF-L cerebrospinal fluid (CSF) following treatment mesenchymal stem cells (MSC) patients progressive MS.The CSF samples obtained from 48 MS who participated double-blind randomized phase II clinical trial that tested effects intrathecal...
CD44 is a multi-functional receptor with multiple of isoforms engaged in modulation cell trafficking and transmission apoptotic signals. We have previously shown that injection anti-CD44 antibody into NOD mice induced resistance to type 1 diabetes (T1D). In this communication we describe our efforts understand the mechanism underlying effect. found CD44-deficient develop stronger T1D than wild-type littermates. This effect not explained by involvement migration, because inflammatory cells...