A5082376030- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Management and Research
- NF-κB Signaling Pathways
- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Genetics and Neurodevelopmental Disorders
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- interferon and immune responses
- Epigenetics and DNA Methylation
University of Copenhagen
2015-2022
Novo Nordisk Foundation
2020-2022
Hadassah Medical Center
2015-2021
Hadassah Academic College
2009-2013
The mammalian pancreas is a branched organ that does not exhibit stereotypic branching patterns, similarly to most other glands. Inside branches, it contains network of ducts undergo transition from unconnected microlumen mesh interconnected and finally treelike structure. This ductal remodeling poorly understood, both on microscopic macroscopic level. In this article, we quantify the properties at different developmental stages. We find pancreatic exhibits traits each stage change with time...
Abstract Diabetes is a multifactorial disorder characterized by loss or dysfunction of pancreatic β-cells. β-cells are heterogeneous, exhibiting different glucose sensing, insulin secretion and gene expression. They communicate with other endocrine cell types via paracrine signals between gap junctions. Here, we identify the importance signaling extracellular signal WNT4. We show heterogeneity in Wnt4 expression, most strikingly postnatal maturation period, -positive cells, being more mature...
Pancreatic islet transplantation, a treatment for type 1 diabetes, has met significant challenges, as substantial fraction of the mass fails to engraft, partly due death by apoptosis in peri- and post-transplantation periods. Previous evidence suggested that NF-κB activation is involved cytokine-mediated β-cell regulates expression pro-inflammatory chemokine genes. We therefore sought explore effects β-cell-specific inhibition means cytoprotection an allogeneic model transplantation. To this...
CD44 is a multi-functional receptor with multiple of isoforms engaged in modulation cell trafficking and transmission apoptotic signals. We have previously shown that injection anti-CD44 antibody into NOD mice induced resistance to type 1 diabetes (T1D). In this communication we describe our efforts understand the mechanism underlying effect. found CD44-deficient develop stronger T1D than wild-type littermates. This effect not explained by involvement migration, because inflammatory cells...
Insulin-producing pancreatic β cells are functionally impaired or destroyed in diabetes mellitus. The onset of type 1 (T1D) represents the culmination a prolonged prediabetic phase immune-mediated β-cell destruction. To assess vivo metabolic status these cells, we used ATP-sensitive firefly luciferase bioluminescence imaging approach, as noninvasive probe to monitor pathological alterations function nonobese-diabetic (NOD) mouse model T1D. Hence, generated Tolβ-NOD transgenic mice which...
Abstract NF-κB is a well-characterized transcription factor, widely known for its roles in inflammation and immune responses, as well control of cell division apoptosis. However, function β-cells still being debated, it appears to depend on the timing kinetics activation. To elucidate temporal role vivo, we have generated two transgenic mouse models, ToIβ NOD/ToIβ mice, which activation specifically conditionally inhibited β-cells. In this study, present novel canonical pathway during murine...