A5063001444- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Genetics and Neurodevelopmental Disorders
- Autophagy in Disease and Therapy
- Cardiac Ischemia and Reperfusion
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- High Altitude and Hypoxia
- Circular RNAs in diseases
- Neuroscience of respiration and sleep
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disorders and Treatments
- Acupuncture Treatment Research Studies
- Migraine and Headache Studies
- Alzheimer's disease research and treatments
- Neuroblastoma Research and Treatments
- Cancer-related gene regulation
- Neonatal and fetal brain pathology
Baotou Medical College
2015-2025
Krirk University
2022-2025
Shenzhen Third People’s Hospital
2022-2025
Shantou University
2006-2025
Shantou University Medical College
2006-2025
Capital Medical University
2007-2024
Shenzhen University
2022-2024
Inner Mongolia University of Science and Technology
2015-2020
University of Chinese Academy of Sciences
2020
Xing Wei College
2020
Ischemic tolerance in the brain can be induced by transient limb ischemia, and this phenomenon is termed remote ischemic preconditioning (RIPC). It still remains elusive how transfer of occurs. Exosomes cross blood-brain barrier, some molecules may neuroprotective signals from periphery to brain. Serum miRNA-126 associated with stroke, exosomal has shown protective effects against acute myocardial infarction. Therefore, study aims explore whether RIPC serum play a similar role. were isolated...
It is well known that cobalt chloride (CoCl2) can enhance the stability of hypoxia-inducible factor (HIF)-1α. The aim this study to detect effect CoCl2 on hypoxia tolerance mice which were repeatedly exposed autoprogressive hypoxia. Balb/c randomly divided into groups chemical pretreatment and normal saline (NS), respectively injected with NS 3 h before exposure for 0 run (H0), 1 (H1), 4 runs (H4). Western Blot, electrophoretic mobility shift assay (EMSA), extracellular recordings population...
Introduction: Rare-earth nanoparticles in the environment and human body pose a potential threat to health. Although toxic effects of rare-earth have been extensively studied, on early development are not well understood. In this study, we attempted explain neodymium oxide (Nd 2 O 3 ) development. Methods: We added Nd at different concentrations recorded mortality malformation rate per 24 hrs under microscope. The live embryos treated with were imaged as movies Z step lapses confocal...
Hypoxic preconditioning (HPC) as an endogenous mechanism can resist hypoxia/ischemia injury and exhibit protective effects on neurological function including learning memory. Although underlying molecular mechanisms remain unclear, HPC probably regulates the expression of molecules by modulating DNA methylation. Brain-derived neurotrophic factor (BDNF) activates its signaling upon binding to tropomyosin-related kinase B (TrkB) receptor, which is involved in neuronal growth, differentiation,...
Apart from being a primary cause of morbidity and mortality globally, gastrointestinal (GI) disorders also contribute significantly to the cost healthcare. In patients with GI diseases, systemic inflammatory response index (SIRI) is not often used as marker immune inflammation assess mortality-associated risk malignant neoplasms or all causes. Therefore, objective this study was elaborate on link between SIRI causes neoplasm in disorders. Retrospective analysis performed using National...
Background: When type 2 diabetes mellitus (T2DM) occurs concomitantly with ischemic stroke, it poses a major challenge to global public health and is related poor prognosis. Inflammation crucial factor driving the progression of this condition. The systemic immune-inflammation index (SII), which was considered capable comprehensively assessing overall immunity inflammation, has relationship mortality T2DM patients suffering from stroke that not yet been fully clarified. This study seeks...
Depression, a neurological disorder triggered by stressful stimuli such as hypoxia, is associated with high morbidity and mortality. Hypoxic preconditioning (HPC) an endogenous mechanism that has been used in recent research to upregulate BDNF, marker of depression, elicit neuroprotective effects. However, the mechanisms which HPC protects against depression remain poorly understood. Therefore, this study aimed investigate effects on depressive behaviors via BDNF signaling. Initially, ICR...
Previous studies have indicated a neuroprotective effect of remote limb ischemic preconditioning. The aim the present study was to assess whether upper arm preconditioning is feasible and safe in patients with unilateral middle cerebral artery (MCA) stenosis compared healthy volunteers. Ten MCA 24 volunteers underwent preconditioning, consisting five cycles 5-min inflations blood pressure cuff 200 mmHg around an followed by 5 min reperfusion. Limb has no significant on heart rate,...
The relationship between the Blood Urea Nitrogen to Albumin Ratio (BAR) and cardiovascular diseases in diabetes, as well all-cause mortality, is not yet entirely understood. This study aimed examine correlation serum urea nitrogen albumin ratio diseases, mortality diabetes. A total of 7043 adult diabetes patients were included from NHANES database 2001 2018. BAR with mellitus was verified using baseline characteristic analysis, multivariate logistic regression Cox proportional hazards model,...
Proteomics of the synapses and postsynaptic densities (PSDs) have provided a deep understanding protein composition signal networks in adult brain, which underlie neuronal plasticity neurodegenerative or psychiatric disorders. However, there is paucity knowledge about architecture organization PSDs immature how it modified by brain injury an early developing stage. Mass spectrometry (MS)-based proteomic analysis was performed on prepared from cortices postnatal day 9 naïve mice pups had...
Epigenetic processes such as DNA methylation are essential for of gene expression in normal mammalian development. methyltransferases (DNMT) responsible initiating and maintaining methylation. It is known that 5-Aza-CdR, an inhibitor DNMT induces cytotoxicity by reducing activity various tumor cell lines. However, disturbances neuronal may also play a role altered brain functions. Thus, it was interest to determine whether alterations might be associated with functions using on mouse...
This work aims at investigating the neuroprotective effects of neuroglobin (Ngb) in vivo and vitro. RT-PCR Western blotting were used to examine Ngb mRNA protein levels mouse cortex after acute repeated exposure hypoxia. The cDNAs cloned transfected into SH-SY5Y cells function Expression was upregulated mice preconditioned by repetitive Tolerance hypoxia Ngb-transformed enhanced. These results suggest that might be involved hypoxic preconditioning which protects neurons from injury.
Disturbances in DNA methylation are postulated to result various central nervous system diseases including Alzheimer's disease (AD). The SH-SY5Y neuronal cell line treated with Aβ1-40 (5 μmol/L) protein is considered be a model of AD. Hence the aim this study was examine influence Schizandrol A, plant extract, on cells exposed Aβ1-40. were incubated varying concentrations Sehizandrol A final concentration 1 (low), 3 (intermediate) or 9 μg/ml (high). Exposure reduced viability, and altered...
Our previous study found that 5-Aza-2′-deoxycytidine (5-Aza-CdR) can repress the expression and activity of protein serine/threonine phosphatase-1γ (PP1γ) in mouse hippocampus. It is well known PP1γ regulates cell metabolism, which related to hypoxia/ischaemia tolerance. has been reported it also induce autophagy cancer cells. Autophagy important for maintaining cellular homeostasis associated with metabolism. In this study, we examined whether 5-Aza-CdR increases hypoxia tolerance-dependent...
Abstract Cerebral ischaemia is a common cerebrovascular disease and often induces neuronal apoptosis, leading to brain damage. Polygalasaponin F (PGSF) one of the components in Polygala japonica Houtt, it triterpenoid saponin monomer. This research focused on anti‐apoptotic effect PGSF during oxygen‐glucose deprivation reoxygenation (OGD/R) injury rat adrenal pheochromocytoma cells (PC12) primary cortical neurons. OGD/R treatment reduced viability PC12 was prevented by PGSF, as shown MTT...
This work aims at investigating the effects of hypoxic preconditioning on hypoxia-inducible factor-1 alpha (HIF-1alpha) expression in hippocampus mice during acute and repeated exposures. The were randomly divided into three groups exposed, respectively, to hypoxia for 4 runs (group H4), 1 run H1), 0 H0). Reverse transcription-polymerase chain reaction (RT-PCR), Western blot, electrophoretic mobility shift assay (EMSA), chromatin immunoprecipitation used examine HIF-1alpha responses mouse...