A5081737576- Bacterial Genetics and Biotechnology
- Plant Pathogenic Bacteria Studies
- Porphyrin Metabolism and Disorders
- Endoplasmic Reticulum Stress and Disease
- Enzyme Structure and Function
- Enzyme Production and Characterization
- Biochemical and Structural Characterization
- Vibrio bacteria research studies
- Neonatal Health and Biochemistry
- Microbial metabolism and enzyme function
- Crystallization and Solubility Studies
- RNA and protein synthesis mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- X-ray Diffraction in Crystallography
- Plant Stress Responses and Tolerance
- Genomics, phytochemicals, and oxidative stress
- Lipid Membrane Structure and Behavior
- Entrepreneurship Studies and Influences
- Micro and Nano Robotics
- Microbial Metabolism and Applications
- Biomimetic flight and propulsion mechanisms
- Neuroendocrine regulation and behavior
- Genomics and Phylogenetic Studies
- Alcohol Consumption and Health Effects
- Galectins and Cancer Biology
AstraZeneca (Brazil)
2025
Beihang University
2024
Queen Mary University of London
2012-2024
The First People's Hospital of Changzhou
2024
Shenyang Agricultural University
2023
Rice Research Institute
2023
People 's Hospital of Jilin Province
2014-2020
Chengdu Medical College
2018
Jilin University
2015
University of Kent
2013
The mechanisms underlying cisplatin resistance in tumors are not fully understood. Previous studies have reported that cellular to oxidative stress is accompanied by cisplatin. However, the relationship between and drug human ovarian cancer cells (HOCCs) clear. Here, we reveal a critical role for multifunctional protein p62/SQSTM1 (HOCCs). (sequestosome 1) plays important roles cell differentiation, proliferation as an antiapoptotic molecule. We found cisplatin-resistant SKOV3/DDP express...
Gram-negative bacteria secrete virulence factors and assemble fibre structures on their cell surface using specialized secretion systems. Three of these, T2SS, T3SS T4PS, are characterized by large outer membrane channels formed proteins called secretins. Usually, a cognate lipoprotein pilot is essential for the assembly secretin in membrane. The pilotins T4PS have been described. However molecular mechanism this process poorly understood its structural basis unknown. Here we report crystal...
Carbon monoxide (CO) is considered as a new emerging cell signal molecule which involved in plant growth, development, and acquisition of stress tolerance. In recent years, hydrogen sulfide (H2S) has been found to have similar functions, but crosstalk between CO H2S the heat tolerance plants not clear. this study, pretreatment tobacco (Nicotiana tabaccum L.) cells cultured suspension with donor hematin significantly increased survival percentage under regrowth ability after stress,...
Abstract Rice (Oryza sativa L.) is a cold-sensitive species that often faces cold stress, which adversely affects yield productivity and quality. However, the genetic basis for low-temperature adaptation in rice remains unclear. Here, we demonstrate 2 functional polymorphisms O. SEC13 Homolog 1 (OsSEH1), encoding WD40-repeat nucleoporin, between subspecies japonica indica rice, may have facilitated rice. We show OsSEH1 of variety expressed OsSEH1MSD plants (transgenic line overexpressing...
Advancements in single-cell technologies and deep sequencing have revealed the vast B-cell repertoire arising from immunisation, enhancing number of antibodies available for testing. However, selecting highest affinity many sequences is not a straightforward feat, as mechanisms sustaining maturation related markers remain under-studied. Here, we generated datasets antigen-specific B-cells after mouse immunisation well re-analysed public data to identify novel transcriptomic signature, "High...
The secretins are a family of large multimeric channels in the outer membrane Gram-negative bacteria that involved protein export. In Dickeya dadantii and many other pathogenic bacteria, lipoprotein pilotin targets secretin subunits to membrane, allowing functional type II secretion system be assembled. Here, crystal structure C-terminal peptide subunit bound its cognate is reported. solution, this region nonstructured. folds on binding form just under four turns α-helix which bind tightly...
Drug resistance greatly limits the therapeutic efficacy of treatment non-small cell lung cancer (NSCLC). One important factors is dysfunction tumor suppressor p53. Recent studies have suggested that p53 suppresses tumors by regulating number mitochondrial proteins, including peroxisome proliferator-activated receptor coactivator (PGC1α). Although several confirmed interaction between and PGC1α, precise mechanism has not been completely determined in NSCLC. In this study, we investigated...
Abstract CobK catalyzes the essential reduction of precorrin ring in cobalamin biosynthetic pathway. The crystal structure reveals that enzyme, despite not having signature sequence, comprises two Rossmann fold domains which bind coenzyme and substrate respectively. parallel β-sheets have swapped their last β-strands giving a novel sheet topology is an interesting variation on Rossmann-fold. trapped ternary complex with product five conserved basic residues carboxylates tetrapyrrole tightly...
The phytopathogenic proteobacterium Dickeya dadantii secretes an array of plant cell wall-degrading enzymes and other virulence factors via the type 2 secretion system (T2SS). T2SSs are widespread among important plant, animal, human bacterial pathogens. This multiprotein complex spans double membrane envelope fully folded proteins through a large outer pore formed by 15 subunits secretin GspD. Secretins also found in 3 4 pili. Usually, specialized lipoproteins termed pilotins assist...
Abstract The preoptic area ( POA ) of the hypothalamus, containing temperature‐sensitive and temperature‐insensitive neurons, plays a key role in specific thermoregulatory responses. Although arginine vasopressin AVP has been shown to induce hypothermia by increasing firing activities warm‐sensitive neurons decreasing those cold‐sensitive effects on GABA ergic transmission remain unknown. Herein, inhibitory postsynaptic currents IPSC s) slices were recorded using whole‐cell patch clamp. By...
To enrich the theoretical research experience of innovation and entrepreneurship talent training mode in colleges universities, build a set guiding systems, this paper deeply discusses driving integration middle class education global education, puts forward specific countermeasures suggestions for reform general higher schools under environment industry education. These efforts aim to promote further development production-education
At present, few articles compare the differences between robot-assisted thoracic surgeries (RATSs) and video-assisted (VATSs) in day surgery model there is also little literature on what factors influence delayed discharge from surgery. This study aims to short-term outcomes RATS VATS for segmental lung resection a setting, identify risk discharge.
Abstract The movement of biological swarms is widespread in nature, and collective behavior enhances a swarm’s adaptability to its environment. However, most research focuses on free swarm movement, overlooking the impact environmental constraints such as tubes. This study examines swimming Petitella georgiae through tube. Observations position, speed, direction reveal that each fish influenced by distribution field view. speed ratio between middle region edge positively correlates with tube...
Objective To study the correlation of expression MUC1 mRNA in peripheral blood with breast cancer and lung cancer,and its diagnostic value on cancer.Methods The serum health control group,benign tumor,breast cancer,lung other groups was collected,then detected by reverse transcriptase polymerase chain reaction (RT-PCR).Results positive rate (10％) benign tumor group had not statistically significant healthy (P ＞ 0.05).The (50％) difference 0.01),MUC1 infiltrating ductal carcinoma highest this...