A5008002361- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Ginseng Biological Effects and Applications
- Cardiac Ischemia and Reperfusion
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- Child and Adolescent Psychosocial and Emotional Development
- Phytochemistry and Biological Activities
- Peroxisome Proliferator-Activated Receptors
- Pain Mechanisms and Treatments
- Genetic Mapping and Diversity in Plants and Animals
- Plant-based Medicinal Research
- Personality Disorders and Psychopathology
- Wheat and Barley Genetics and Pathology
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Alkaloids: synthesis and pharmacology
- Neurological Disorders and Treatments
- Mechanisms of cancer metastasis
- Greenhouse Technology and Climate Control
- Biochemical and Structural Characterization
- Adipose Tissue and Metabolism
Air Force Medical University
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Nanjing Medical University
2023
Nanyang Technological University
2021-2023
Shenyang Agricultural University
2023
Rice Research Institute
2023
The Ohio State University
2023
China Agricultural University
2023
National Engineering Research Center for Information Technology in Agriculture
2023
Shanghai Academy of Agricultural Sciences
2021-2022
Abstract Interferon‐induced transmembrane protein 3 (IFITM3) is an antiviral that alters cell membranes to block fusion of viruses. Conflicting reports identified opposing effects IFITM3 on SARS‐CoV‐2 infection cells, and its impact viral pathogenesis in vivo remains unclear. Here, we show knockout (KO) mice infected with experience extreme weight loss lethality compared mild wild‐type (WT) mice. KO have higher lung titers increases inflammatory cytokine levels, immune infiltration,...
This study investigated whether anticerebral ischemia new drug, l-3-n-butylphthalide (l-NBP), improved behavioral recovery and enhanced hippocampal neurogenesis after cerebral in rats.The middle artery of rats was blocked for 2 h. The daily oral administrations 30 mg/kg l-NBP or vehicle were begun from the second day until sacrificed. L-NBP treatment markedly increased 5-bromo-2'-deoxyuridine (BrdU)-positive cells dentate gyrus (DG) injured hemisphere on 28 ischemia. amount newborn newly...
Our previous studies showed that L-3-n-butylphthalide (L-NBP), an extract from seeds of Apium graveolens Linn (Chinese celery), improved cognitive ability in animal models cerebral ischemia, vascular dementia, and Alzheimer's disease (AD). It is well known deficit AD caused by synaptic dysfunction. In this study, we investigated the effect L-NBP on hippocampal function APP/PS1 transgenic mice related mechanisms.Eighteen-month-old (Tg) were administrated 15 mg/kg oral gavage for 3 months....
Dexmedetomidine (DEX), a common anesthetic, has significant effects on the biological features of cancer cells. Although numerous studies have been published impact DEX characteristics GC cells, mechanism remains unknown. This study aimed to explore effect properties suppressed viability and increased apoptosis cells in vitro inhibited tumor growth vivo. Besides, raised levels reactive oxygen species (ROS) iron, but decreased glutathione (GSH), peroxidase 4 (GPX4), solute carrier family 7...
Abstract Rice (Oryza sativa L.) is a cold-sensitive species that often faces cold stress, which adversely affects yield productivity and quality. However, the genetic basis for low-temperature adaptation in rice remains unclear. Here, we demonstrate 2 functional polymorphisms O. SEC13 Homolog 1 (OsSEH1), encoding WD40-repeat nucleoporin, between subspecies japonica indica rice, may have facilitated rice. We show OsSEH1 of variety expressed OsSEH1MSD plants (transgenic line overexpressing...
Neuropathic pain can occur during the prediabetic stage, even in absence of hyperglycemia. The presence neuropathic (PDNP) poses challenges to management individuals with prediabetes. However, mechanisms underlying this remain unclear. This study aims investigate mechanism and identify potential therapeutic targets PDNP. A animal model induced by a high-energy diet exhibits both mechanical allodynia thermal hyperalgesia. Furthermore, hyperexcitability decreased potassium currents are...
(1) Background: Doxorubicin (DOX) is a frontline chemotherapeutic, but its side effects from oxidative stress leading to cardiotoxicity, pose significant challenges clinical use. We recently discovered novel family of proteolysis-resistant, cystine-dense, and cell-penetrating microproteins Panax ginseng that we term ginsentides. Ginsentides, such as the 31-residue TP1 coordinate multiple biological systems prevent vascular dysfunction endoplasmic reticulum induced by internal external...
Summary Aims To investigate the roles of N‐myc downstream‐regulated gene 2 ( NDRG 2) in pathology aging and neurodegenerative disease such as Alzheimer's AD ). Results In this study, we confirmed upregulation brains animal models. explore role at molecular level, conducted a cell‐based assay highly expressed wild‐type human APP 695 SK ‐N‐ SH cells wt). By silencing overexpressing 2, demonstrated that 2‐mediated increase Aβ 1‐42 was through pathways BACE 1 GGA 3. NGRG improved tau...
Peroxisomes are involved in a wide range of important cellular functions.. We studied Here, the role peroxisomal membrane protein PEX3 proposed docking receptor peroxisome, plant-pathogen and mycotoxin producer Fusarium graminearum was studied. To study function using knock-out complementation strains. were constructed by gene replacements. As import proteins depends on PTS1 PTS2 signatures , fluorescently label peroxisomes punctate structures, GFP RFP fusions with localization signal...
Background and Purpose The Rho GTPase, Rac1, is involved in the pathogenesis of neuropathic pain induced by malformation dendritic spines spinal dorsal horn (sDH) neurons. In present study, contribution Rac1 to peripheral inflammatory was studied. Experimental Approach Effects s.c. bee venom (BV) injection on cellular localization rat sDH determined with double labelling immunofluorescence. Activation its downstream effector p21‐activated kinase (PAK), ERKs p38 MAPK states evaluated a...
Stress and illness connection is complex involves multiple physiological systems. Panax ginsengs, reputed for their broad-spectrum "cure-all" effect, are widely prescribed to treat stress related illnesses. However, the identity of ginseng's medicinal compounds that relieve remains unresolved. Here, we identify ginsentides as principal bioactives coordinate systems restore homeostasis in response stress. Ginsentides disulfide-rich, cell-penetrating proteolytic-stable microproteins. Using...
Abstract Potassium channel dysfunction has been implicated in apoptosis many pathological conditions. However, which Kv subunit is involved glutamate‐induced remains unknown. In this study, the contributions of nine Kvα and three Kvβ subunits to hippocampal neuronal were investigated. Results showed that was not obvious with 12 hr incubation glutamate but increased markedly after 18 hr, attenuated by blocker TEA. Among all investigated, gene protein expression Kv2.1 significantly before...
Here, we report the discovery of first plant-derived and noncanonical epidermal growth factor receptor (EGFR) agonist, 36-residue bleogen pB1 from Pereskia bleo Cactaceae family. We show that is a low-affinity EGFR agonist using suite chemical, biochemical, cellular, animal experiments which include incisor eruption wound-healing mouse models. A focused positional scanning library Ala- d-amino acid scans yielded high-affinity analog, [K29k]pB1, with 60-fold-improved affinity mitogenicity....
Eighteen compounds were isolated by a combination of various chromatographic techniques including column chromatography over macroporous resin, MCI gel, silica and sephadex LH-20 reversed-phase HPLC. Their structures elucidated spectroscopic data analysis as adinoside A (1), stryspinoside (2), benzyl alcohol beta-glucopyranoside (3), 2-o-beta-D-glucopyranosyl-2,6-dihydroxybenzoate (4) , gentisic acid 2-O-beta-D-glucopyranoside (5), eugenyl beta-D-glucopyranoside (6)...
Abstract Aims Pathogenesis of diabetic encephalopathy (DE) is not completely understood until now. The purposes this study were to illustrate the changes in morphology, function, and important transporters neurons glia during DE, as well reveal potential therapeutic effects medicines diet control on DE. Methods Spontaneous obese KK‐Ay mice used investigate diabetes‐induced cognitive disorder, protein expression impact animal cell level studies. new drug candidate PHPB, donepezil, low‐fat...
Abstract Ginseng has been known as a “cure-all” traditional medicine to treat various illnesses and an adaptogen relieve stress. However, the active compounds of ginseng are small-molecule metabolites. Here we report ginsentides, which disulfide-dense, super-stable cell-penetrating peptides with 31–33 amino acids, adaptogens that restore homeostasis in response Using mass spectrometry-based target identification functional studies, show ginsentides promote vasorelaxation by producing nitric...
Abstract Aims dl ‐PHPB (potassium 2‐(1‐hydroxypentyl)‐benzoate) has been shown to have neuroprotective effects against acute cerebral ischemia, vascular dementia, and Alzheimer's disease. The aim of this study was investigate the on memory deficits preliminarily explore underlying molecular mechanism. Methods Blood glucose behavioral performance were evaluated in KK‐A y diabetic mouse model before after administration. Two‐dimensional difference gel electrophoresis (2D‐DIGE)‐based proteomics...
Kv2.1 is widely expressed in brain, and inhibiting a potential strategy to prevent cell death achieve neuroprotection ischemic stroke. Herein, an silico model of tetramer structure was constructed by employing the AlphaFold-Multimer deep learning method facilitate rational discovery inhibitors. GaMD utilized create ion transporting trajectory, which analyzed with HMM generate multiple representative receptor conformations. The binding site RY785 RY796(S) under P-loop defined Fpocket program...
Abstract Background The overall genetic distribution and divergence of cloned genes among bread wheat varieties that have occurred during the breeding process over past few decades in Ningxia Province, China, are poorly understood. Here, we report diversities 44 important related to grain yield, quality, adaptation resistance 121 86 introduced cultivars advanced lines. Results population structure indicated characteristics components wheat, including landraces particular resources, with rich...
Aging of the nervous system leads to impairments in cognition and motor skills, is a major risk factor for several neurological disorders. Recently, numerous nerve function deficits that appear with aging have been found be consequence myelin abnormalities; however, genetic mechanism age‑related alterations sheath has not yet fully elucidated. In present study, morphology optic rats was analyzed at 10 time‑points throughout life. Marked were observed aged nerves, these became progressively...
Abstract Bactrocera tsuneonis and minax are the most destructive pests that damage citrus in China. These key hinder trade, cause significant financial losses, drastically lower production quality, decrease farmer enthusiasm for planting. B. very similar all life stages. There limited morphological characteristics to differentiate adult species, it is nearly impossible these two species egg larval Loop-mediated isothermal amplification (LAMP) a rapid robust diagnostic tool used identify...