A5075320171- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Radiation Effects and Dosimetry
- Cancer, Hypoxia, and Metabolism
- Ocular Oncology and Treatments
- Dental Radiography and Imaging
- Thermography and Photoacoustic Techniques
- Advanced X-ray Imaging Techniques
- Luminescence Properties of Advanced Materials
- Advanced MRI Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Advanced X-ray and CT Imaging
- Dental Implant Techniques and Outcomes
- Radiation Effects in Electronics
- Oral health in cancer treatment
- Glioma Diagnosis and Treatment
- Advanced Optical Sensing Technologies
Chris O’Brien Lifehouse
2022-2023
The University of Sydney
2023
University of Wollongong
2009-2021
Wollongong Hospital
2012-2017
Synchrotron facilities produce ultra-high dose rate X-rays that can be used for selective cancer treatment when combined with micron-sized beams. microbeam radiation therapy (MRT) has been shown to inhibit growth in small animals, whilst preserving healthy tissue function. However, the underlying mechanisms successful MRT outcomes are not well understood, either vitro or vivo. This study provides new insights into relationships between dosimetry, transport simulations, cell response, and...
Microbeam Radiation Therapy (MRT) is a radiation treatment technique under development for inoperable brain tumors. MRT based on the use of synchrotron generated X-ray beam with an extremely high dose rate ( ∼ 20 kGy/sec), striated into array micro-blades. In order to advance clinical trials, real-time dosimeter excellent spatial resolution must be developed absolute dosimetry. The design such scenario represents significant challenge due photon flux and vertically field, leading very steep...
A radiotherapy bolus is a tissue-equivalent material placed on the skin to adjust surface dose of megavoltage X-ray beams used for treatment. In this study, dosimetric properties two 3D-printed filament materials, polylactic acid (PLA) and thermoplastic polyether urethane (TPU), as boluses, were investigated. The PLA TPU compared with those several conventional materials RMI457 Solid Water. Percentage depth-dose (PDD) measurements in build-up region performed all using 6 10 MV photon...
In this study, we demonstrate that the X-Tream dosimetry system developed by Centre for Medical Radiation Physics can be used with both commercial and non-commercial dosimeters. A custom adaptor was constructed to connect PTW microdiamond DAQ. This allowed measurements of continuous depth dose curves, broad beam microbeam profiles. The enables real time measurement instantaneous rate synchrotron generated radiation microDiamond. Finally, undertaken in study is able mitigate alignment issue...
Successful transition of synchrotron-based microbeam radiation therapy (MRT) from pre-clinical animal studies to human trials is dependent upon ensuring that there are sufficient and adequate measures in place for quality assurance purposes. Transmission detectors provide researchers clinicians with a real-time beam-monitoring instrument ensure safe accurate dose delivery. In this work, the effect transmission different thicknesses (10 375 µm) photon energy spectra deposition spatially...