A5069088895- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Selenium in Biological Systems
- Biochemical Analysis and Sensing Techniques
- Congenital Diaphragmatic Hernia Studies
- Glutathione Transferases and Polymorphisms
- Parasites and Host Interactions
- Genetic Syndromes and Imprinting
- Helminth infection and control
- Intraperitoneal and Appendiceal Malignancies
- Parasite Biology and Host Interactions
- Metabolism, Diabetes, and Cancer
- Animal Nutrition and Physiology
- Sulfur Compounds in Biology
- Liver Disease Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Meat and Animal Product Quality
- Neuroscience of respiration and sleep
- Appendicitis Diagnosis and Management
- Redox biology and oxidative stress
- Digital Imaging in Medicine
- Occupational and environmental lung diseases
- Environmental Toxicology and Ecotoxicology
- Trace Elements in Health
- Diet, Metabolism, and Disease
National Institute of Diabetes and Digestive and Kidney Diseases
2024
University of Chicago
2022
National Institutes of Health
2001-2018
Cancer Genetics (United States)
2015
Center for Cancer Research
2012
Melanocortin 4 receptor (MC4R) mutations are the most common cause of human monogenic obesity and associated with hyperphagia increased linear growth. While MC4R is known to activate Gsα/cAMP signaling, a significant proportion obesity-associated do not affect MC4R/Gsα signaling. To further explore role specific signaling pathways in regulation energy balance, we examined properties one such mutant (F51L), as well metabolic consequences MC4RF51L mutation mice. The produced defect MC4R/Gq/11α...
Selenocysteine is a rare amino acid in protein that encoded by UGA with the requirement of downstream mRNA stem-loop structure, selenocysteine insertion sequence element. To detect selenoproteins <i>Drosophila</i>, entire genome was analyzed novel program searches for elements, followed selenoprotein gene signature analyses. This computational screen and subsequent metabolic labeling <sup>75</sup>Se characterization expression resulted identification three selenoproteins: selenophosphate...
Secretoglobin 3A2 (SCGB3A2) was originally identified as a downstream target in lung for the homeodomain transcription factor NKX2-1, whose null mutation resulted severely hypoplastic lungs. A very low level of SCGB3A2 is expressed lungs at Embryonic Day (E) 11.5 during mouse development, which markedly increases by E16.5, time when undergoes dramatic morphologic changes, suggesting that may be involved development addition to known role inflammation.To determine whether plays development.To...
Selenium is an essential trace element in mammals, but toxic at high levels. It best known for its cancer prevention activity, cells are more sensitive to selenite toxicity than normal cells. Since treatment leads oxidative stress, and the Trx (thioredoxin) system a major antioxidative system, we examined interplay between TR1 (Trx reductase 1) Trx1 deficiencies DT cells, malignant mouse cell line, corresponding parental NIH 3T3 TR1-deficient were far Trx1-deficient or control In contrast,...
The central melanocortin α-MSH acts through MC4R receptors, which are known to activate Gsα/cAMP signaling, promote negative energy balance by inhibiting food intake (FI) and stimulating expenditure (EE). However, we have shown that mice with Gsα deficiency become obese decreased EE but without hyperphagia, inhibition of in the paraventricular nucleus hypothalamus (PVN) is mediated via G proteins Gqα/G11α. Previous vitro studies also several mutations associated early-onset human obesity,...
Corresponding author: Bradley Carlson, is global product manager at TouchPoint Medical, 315 River Street, Forty Fort, PA 18704. He can be reached [email protected]. The author declares no conflicts of interest.