A5013767552- Skin Protection and Aging
- melanin and skin pigmentation
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Acne and Rosacea Treatments and Effects
- Thermoregulation and physiological responses
- Bioactive natural compounds
- Agriculture and Biological Studies
- Regulation of Appetite and Obesity
- Chromatography in Natural Products
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Biochemical Analysis and Sensing Techniques
- Phytochemicals and Medicinal Plants
- Phytochemicals and Antioxidant Activities
- RNA Research and Splicing
- Cannabis and Cannabinoid Research
- Metabolomics and Mass Spectrometry Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Optical Coherence Tomography Applications
- Exercise and Physiological Responses
- Advancements in Transdermal Drug Delivery
- Pancreatitis Pathology and Treatment
- Traditional Chinese Medicine Analysis
- Cardiovascular Disease and Adiposity
RTX (United States)
2021-2022
Johnson & Johnson (United States)
2013-2019
George Mason University
2005-2012
Genomics (United Kingdom)
2008
Inova Health System
2008
Universities UK
1984
Visible light (400–700 nm) lies outside of the spectral range what photobiologists define as deleterious radiation and a result few studies have studied effects visible wavelengths on skin. This oversight is important considering that during outdoors activities skin exposed to full solar spectrum, including light, multiple exposures at different times doses. Although contribution UV component sunlight damage has been established, examined non-UV physiology in terms inflammation, limited...
Melanin is a common pigment in animals. In humans, melanin produced melanocytes, retinal epithelium (RPE) cells, the inner ear, and central nervous system. Previously, we noted that human adipose tissue expresses several melanogenesis-related genes. current study, confirmed expression of mRNAs proteins using real-time polymerase chain reaction immunohistochemical staining. TYR mRNA signals were also detected by situ hybridization visceral adipocytes. The presence was revealed both...
Sunscreens are known to protect from sun damage; however, their effects on the reversal of photodamage have been minimally investigated.The aim prospective study was evaluate efficacy a facial protection factor (SPF) 30 formulation for improvement during 1-year use.Thirty-two subjects applied broad spectrum photostable sunscreen (SPF 30) 52 weeks entire face. Assessments were conducted through dermatologist evaluations and subjects' self-assessment at baseline then Weeks 12, 24, 36,...
Skin chronically exposed to sun results in phenotypic changes referred as photoaging. This aspect of aging has been studied extensively through genomic and proteomic tools. Metabolites, the end product are generated a result biochemical reactions often culmination complex interplay gene protein expression. In this study, we focused exclusively on metabolome study effects from sun-exposed sun-protected skin sites 25 human subjects. We highly accurate metabolomic signature for that is sun....
It is very well known that exposure of skin to sun chronically accelerates the mechanism aging as making it more susceptible toward cancer. This aspect has been studied through genomics and proteomics tools. In this study we have used a metabolomic approach for first time determine differences in metabolome from full thickness biopsies exposed protected sites. We primarily investigated energy metabolism oxidative pathway skin. Biochemical analysis revealed photoexposed predominantly...
Tetrahexyldecyl Ascorbate (THDC) is an L-ascorbic acid precursor with improved stability and ability to penetrate the epidermis. The transdermal penetration of THDC, however, may be compromised by oxidant-rich environment human skin. In this study, we show that THDC a poor antioxidant degrades rapidly when exposed singlet oxygen. This degradation, was prevented combination acetyl zingerone (AZ) as stabilizing antioxidant. As standalone ingredient, led unexpected activation type I interferon...
Background: Identification of long-lasting natural antioxidants to protect against and repair skin damage induced by exposure environmental pollution is in high demand. Objective: To investigate a standardized Terminalia chebula (TC) fruit extract for its antioxidant anti-inflammatory properties ability reverse the visible signs pollution-induced an 8-week clinical study. Material Methods: Chemical cell-based vitro studies were performed characterize properties; study with subjects normal...
The endocannabinoid (eCB) system plays an active role in epidermal homeostasis. Phytocannabinoids such as CBD modulate this but also act through eCB-independent mechanisms. This study evaluated effects of CBD, bakuchiol (BAK) and ethyl (linoleate/oleate) (ELN) keratinocytes (KCs) reconstituted human epidermis (RHE). Molecular docking simulations showed that each compound binds the site eCB carrier fatty-acid-binding protein 5 (FABP5). However, BAK linoleate bound with highest affinity when...
Introduction: As skin ages, it loses its ability to retain moisture and becomes rough dry. This results in a clinically dull appearance with loss of radiance, firmness, suppleness. Symptoms can be improved use moisturizer that builds maintains hydration over time; however, most moisturizers occlude the surface are perceived as heavy greasy not consumer preferred. Methods: A unique, consumer-preferred gel matrix formula was developed by combining liquid crystal structures, which mimic barrier...