A5009070590- Skin Protection and Aging
- Ion channel regulation and function
- Dermatology and Skin Diseases
- Pancreatic function and diabetes
- Cellular transport and secretion
- Ion Transport and Channel Regulation
- Genomics, phytochemicals, and oxidative stress
- Ion Channels and Receptors
- Cystic Fibrosis Research Advances
- Dermatologic Treatments and Research
- melanin and skin pigmentation
- Thermoregulation and physiological responses
- Neonatal skin health care
- Optical Coherence Tomography Applications
- NF-κB Signaling Pathways
- Mast cells and histamine
- Pharmacological Effects of Natural Compounds
- Planarian Biology and Electrostimulation
- RNA regulation and disease
- Circadian rhythm and melatonin
- Contact Dermatitis and Allergies
- Advanced Sensor and Energy Harvesting Materials
- Plant Toxicity and Pharmacological Properties
- Microtubule and mitosis dynamics
- Ginger and Zingiberaceae research
Johnson & Johnson (United States)
2010-2021
Skin Research Center
2011
Stevens Institute of Technology
2005-2010
The gateway for molecular trafficking between the cytoplasm and nucleus is Nuclear Pore Complex (NPC). Through mass spectral analysis of isolated Nup107-160 subcomplex, we discovered an in vivo interaction with Werner's Helicase Interacting Protein 1, (WRNIP1 or WHIP). WHIP was originally identified as a binding partner Werner protein (WRN), which functions to maintain genome stability responsible progeria disease, syndrome. We established reciprocal isolation Nup107 by alpha-WHIP. found...
The nuclear factor‐κB (NF‐κB) pathway is a key mediator of inflammation; however, few studies have examined the direct effects NF‐κB inhibition on skin. To investigate activity in cultured human fibroblasts and to 4‐hexyl‐1,3‐phenylenediol (an inhibitor) elastin collagen gene expression vitro clinical appearance photodamaged amount obtained from donors (17–78 years old) was measured after transfection with reporter luciferase promoter system. extracellular matrix (ECM) genes determined using...
The amiloride-sensitive epithelial sodium channel (ENaC), a plasma membrane protein mediates reabsorption in tissues, including the distal nephron and colon.Syntaxin1A, trafficking of t-SNARE family has been reported to inhibit ENaC Xenopus oocyte expression artificial lipid bilayer systems.The present report describes regulation by syntaxin1A human cell line that is physiologically relevant as it expresses both components also responds aldosterone stimulation.In order evaluate physiological...
Computational models of skin permeability are typically based on assumptions fixed geometry and homogeneity the whole epidermis or epidermal strata often limited to adult skin. Infant differs quantitatively from that in its structure functional properties, including barrier function permeation. To address this problem, we developed a self-organizing multicellular model formation with realistic cell morphology. By modulating parameters relating turnover reflecting those infant epidermis, were...
The loss of structural elastin due to intrinsic and extrinsic ageing results in the skin's inability stretch recoil (decrease elasticity) manifests as skin firmness sagging. While other extracellular matrix (ECM) components such collagen hyaluronic acid are continually synthesized assembled through life, elastic fibres not. Elastic fibre assembly functionality require cross-linking, induced by lysyl oxidase-like (LOXL) enzymes, which sharply decrease during ageing.To evaluate enhanced...