A5005406726- Eicosanoids and Hypertension Pharmacology
- Natural product bioactivities and synthesis
- Hormonal Regulation and Hypertension
- Inflammatory mediators and NSAID effects
- Cancer, Hypoxia, and Metabolism
- Pharmacogenetics and Drug Metabolism
- Diabetes Management and Research
- Renin-Angiotensin System Studies
- Phytochemistry and Biological Activities
- Peroxisome Proliferator-Activated Receptors
- Chronic Kidney Disease and Diabetes
- Estrogen and related hormone effects
- Sesquiterpenes and Asteraceae Studies
- Synthesis and biological activity
- Plant Toxicity and Pharmacological Properties
- Traditional Chinese Medicine Analysis
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- PARP inhibition in cancer therapy
- Diabetes Treatment and Management
- Electrolyte and hormonal disorders
- Phytochemical compounds biological activities
- Inflammasome and immune disorders
- Lipoproteins and Cardiovascular Health
Union Hospital
2025
Jilin University
2025
Guangxi University
2023
Guangxi University of Chinese Medicine
2018-2023
Shenyang Pharmaceutical University
2016-2017
Vanderbilt University
2010-2015
Vanderbilt University Medical Center
2007-2014
Ajou University
2014
Tongji University
2013
Huazhong University of Science and Technology
2005-2013
Renal tubule epithelia represent the primary site of damage in acute kidney injury (AKI), a process initiated and propagated by infiltration macrophages. Here we investigated role resident renal macrophages dendritic cells recovery from AKI after ischemia/reperfusion (I/R) or novel diphtheria toxin–induced (DT-induced) model selective proximal mice. DT-induced was characterized marked tubular cell apoptosis. In both models, macrophage/dendritic depletion during phase increased functional...
Nonthermal plasma (NTP) is generated by ionization of neutral gas molecules, which results in a mixture energy particles including electrons and ions. Recent progress the understanding NTP has led to its application treatment various diseases, cancer. However, molecular mechanisms NTP-induced cell death are unclear. The purpose this study was evaluate mechanism induction apoptosis head neck cancer (HNC) cells. effects on were investigated using MTT, terminal deoxynucleotidyl...
Abstract Cytochrome P450 (CYP) arachidonic acid epoxygenase 2J2 converts to four regioisomeric epoxyeicosatrienoic acids, which exert diverse biological activities in cardiovascular system and endothelial cells. However, it is unknown whether this enzyme highly expresses plays any role cancer. In study, we found that very strong selective CYP2J2 expression was detected human carcinoma tissues 101 of 130 patients (77%) as well eight cell lines but undetectable adjacent normal nontumoric by...
Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EET), which exert diverse biological activities in a variety of systems. We previously reported that the CYP2J2 epoxygenase is overexpressed human cancer tissues and cell lines EETs enhance tumor growth, increase carcinoma proliferation, prevent apoptosis cells. Herein, we report CYP overexpression or EET treatment promotes metastasis independent effects on growth. In different vitro,...
In addition to its role as an essential neurotransmitter, dopamine serves important physiologic functions in organs such the kidney. Although kidney synthesizes through actions of aromatic amino acid decarboxylase (AADC) proximal tubule, previous studies have not discriminated between roles extrarenal and intrarenal overall regulation renal function. To address this issue, we generated mice with selective deletion AADC tubules (referred herein ptAadc-/- mice), which led decreases urinary...
Endothelial cells play a vital role in the maintenance of cardiovascular homeostasis. Epoxyeicosatrienoic acids (EETs), cytochrome P-450 (CYP) epoxygenase metabolites arachidonic acid endothelial cells, possess potent and diverse biological effects within vasculature. We evaluated overexpression CYP epoxygenases on tumor necrosis factor-α (TNF-α)-induced apoptosis bovine aortic cells. significantly increased cell viability inhibited TNF-α induction as by morphological analysis nuclear...
The peroxisomal proliferator-activated nuclear receptor-alpha (PPARalpha), the target for most hypolipidemic drugs in current clinical use, regulates transcription of genes involved lipid metabolism and transport, energy homeostasis. More recently, PPARalpha its ligands have been implicated inflammatory responses regulation cell proliferation. also expression Cyp4a fatty acid omega-hydroxylases Cyp2c arachidonic epoxygenase genes. To study role receptor gene tumorigenesis, we treated mice...
Inhibition of prostaglandin (PG) production with either nonselective or selective inhibitors cyclooxygenase-2 (COX-2) activity can induce exacerbate salt-sensitive hypertension. This effect has been previously attributed to inhibition intrinsic renal COX-2 and subsequent increase in sodium retention by the kidney. Here, we found that macrophages isolated from kidneys high-salt–treated WT mice have increased levels microsomal PGE synthase–1 (mPGES-1). Furthermore, BM transplantation (BMT)...
Diabetes is called a "wasting and thirsting disorder" in Chinese traditional medicine because there depletion of vital substances the body independent intake food or water an inability to reintroduce fluids through drinking. Pueraria lobata (Willd.) Ohwi (GG) thomsonii Benth. (FG) are herbal medicines used treatment wasting-thirst that reduce blood glucose levels. Flavonoids main pharmacodynamic components GG FG, they also most studied at present, but polysaccharides active which, however,...
The glucagon response is the first line of defense against hypoglycemia and lost in insulin-dependent diabetes. beta-cell "switch-off" hypothesis proposes that a sudden cessation insulin secretion from beta-cells into portal circulation islet during necessary signal for downstream alpha-cells. Although indirect evidence exists to support this hypothesis, it has not been directly tested vivo by provision then discontinuation regional reinsulinization alpha-cells at time hypoglycemic...
Prevalence and mortality make cancer a health challenge in need of effective better tolerated therapeutic approaches, with tumor angiogenesis identified as promising target for drug development. The epoxygenase products, the epoxyeicosatrienoic acids, are pro-angiogenic, down-regulation their biosynthesis by peroxisomal proliferator-activated receptor α (PPARα) ligands reduces growth. Endothelial cells lacking Cyp2c44 epoxygenase, PPARα target, show reduced proliferative tubulogenic...
Non-small cell lung cancer (NSCLC) not amenable to surgical resection has a high mortality rate, due the ineffectiveness and toxicity of chemotherapy. Thus, there remains an urgent need efficacious drugs that can combat this disease. In study, we show targeting formation proangiogenic epoxyeicosatrienoic acids (EET) by cytochrome P450 arachidonic acid epoxygenases (Cyp2c) represents new safe mechanism treat NSCLC growth progression. transgenic murine K-Ras model human orthotopic models...
Endothelial dysfunction and decreased production of nitric oxide (NO) by endothelial NO synthase (eNOS) are implicated in the pathogenesis hypertension insulin resistance. Because potential influence increased eNOS expression/activity on these parameters is unclear, present study examined effects gene therapy resistance blood pressure alterations a fructose-induced model rats. As predicted, 2 weeks fructose consumption drinking water resulted elevated systolic These other physiologic were...
It is well-recognized that excessive angiotensin II (ANG II) can mediate progressive renal injury. Previous studies by us and others have indicated dopamine may modulate actions of ANG in the kidney. The current investigated whether altering intrarenal levels affected II-mediated fibrosis. We utilized a model increased dopamine, catechol- O-methyl-transferase knockout (COMT KO) mice, which kidney due to deletion major dopamine-metabolizing enzyme. In wild-type chronic infusion expression...
Randomized clinical trials have clearly shown that inhibition of the renin-angiotensin system (RAS) will slow rate progression diabetic nephropathy, but controversy remains about whether observed beneficial effects result from more than control blood pressure. Deletion eNOS in a model type II diabetes, db/db mice (eNOS −/− db/db), induces an accelerated nephropathy and provides excellent human nephropathy. As is frequently seen pressure moderately elevated mice. To determine role per se vs....
// Jian Chang 1,3,* , Li Jiang 1,4,* Yinqiu Wang 1 Bing Yao Shilin Yang Bixiang Zhang 3 and Ming-Zhi 1,2,5 Department of Medicine, Vanderbilt University School Nashville, TN, USA 2 Cancer Biology, Hepatic Surgery Center,Tongji Hospital, Tongji Medical College, Huazhong Science & Technology, Wuhan, China 4 Biliary Pancreatic Surgery, 5 Jiangsu Center for the Collaboration Innovation Biotherapy, Institute, Xuzhou Xuzhou, * These authors contributed equally to this work Correspondence:...
The kidney has a local intrarenal dopaminergic system, and in the kidney, dopamine modulates renal hemodynamics, inhibits salt fluid reabsorption, antagonizes renin-angiotensin oxidative stress. current study examined effects of alterations system on structure function models type 1 diabetes. We studied catechol-O-methyl-transferase (COMT)(-/-) mice, which have increased production due to decreased metabolism, transplantation was used determine whether seen with COMT deficiency were...
Ginsenoside Rb1 (GRb1), a bioactive ingredient of Panax ginseng C. A. Meyer, has the effects anti-tumor, anti-inflammation, and cardiovascular protection. The present study aims to explore potential mechanisms GRb1 on UC. suppressed secretion tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1β in both cells mice models. showed antioxidant inhibited NLR family pyrin domain 3 (NLRP3) inflammasome activation by decreasing ROS production directly targeting Nrf2 activate Nrf2/HO-1/Keap-1...