A5053041908- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Reproductive Biology and Fertility
- Kruppel-like factors research
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- TGF-β signaling in diseases
- Ovarian cancer diagnosis and treatment
- Nuclear Structure and Function
- Circular RNAs in diseases
- Microtubule and mitosis dynamics
- Pregnancy and preeclampsia studies
- Endometriosis Research and Treatment
- Extracellular vesicles in disease
- Prenatal Screening and Diagnostics
- Adipose Tissue and Metabolism
- Pregnancy-related medical research
- Monoclonal and Polyclonal Antibodies Research
- Genetics and Physical Performance
- Fetal and Pediatric Neurological Disorders
- RNA regulation and disease
- Chromosomal and Genetic Variations
- Urological Disorders and Treatments
- Genomic variations and chromosomal abnormalities
Istanbul University
2014-2024
Magee-Womens Research Institute
2023
University of Pittsburgh
2023
Yeditepe University Hospital
2022
Early pregnancy loss (EPL), also termed early miscarriage, is determined as the unintentional expulsion of an embryo or fetus prior to 12th week gestation. EPL frequency ~15% in pregnancies. Fetal development and growth associate with placental function vessel development; therefore, genome would represent a useful miscarriage model for (epi)genetic genomic studies. An important factor epigenetic regulation gene expression. microRNAs (miRNAs) are primary regulators which have role function....
Genetic polymorphism is considered to be associated with human physical performance. The angiotensin I‑converting enzyme insertion/deletion (ACE I/D) and the α-actinin-3 gene (ACTN3) R577X polymorphisms have been widely investigated for such associations, functional ACE I/D ACTN3 sprinter aim of this study was determine effect these on sport performance among 37 elite athletes healthy controls. II genotype identified in 32.43% control group 8.11% athletes, DD 37.84% 51.35% ID 29.73% 40.54%...
Epithelial ovarian cancer (EOC) is the type of OC with highest mortality rate. Due to asymptomatic nature disease and few available diagnostic tests, it mostly diagnosed at advanced stage. Therefore, present study aimed discover predictive and/or early novel circulating microRNAs (miRNAs or miRs) for EOC. Firstly, microarray analysis miRNA expression levels was performed on 32 samples female individuals: Eight plasma from patients pathologically confirmed EOC (mean age, 45 (30-54) years),...
Purpose: Preeclampsia (PE) is a pregnancy specific disease soon after 20 weeks of gestation where major symptoms are hypertension and proteinuria. The underlying pathology believed to be abnormal placentation. Epigenetic genetic factors have significant roles in placental development. MicroRNA's (miRNAs), being one the most important epigenetic regulators, take part Hsa-miR-195 molecule associated with growth mechanisms such as impaired cellular proliferation, inadequate trophoblastic...
This study aims to understand differences/similarities in the genetic profile of endometrium at start window implantation (WOI) women with unexplained infertility (UI) and recurrent pregnancy loss (uRPL). Differentially expressed genes (DEGs) from were evaluated using gene expression array pathway enrichment analysis was performed analyse pathways involved both conditions. We found 2,171 arranged 117 730 33 differentially patients UI uRPL, respectively. Complement-coagulation cascades,...
We recently reported that the transcription factor NFATC4, in response to chemotherapy, drives cellular quiescence increase ovarian cancer chemoresistance. The goal of this work was better understand mechanisms NFATC4-driven chemoresistance.We used RNA sequencing identify NFATC4-mediated differential gene expression. CRISPR-Cas9 and FST (follistatin)-neutralizing antibodies were assess impact loss function on cell proliferation ELISA quantify induction patient samples vitro chemotherapy.We...
The purpose of this study was to identify specific circulating microRNAs (miRNAs) and investigate expression level their target genes for evaluation pathogenesis epithelial ovarian cancer (EOC).In study, we have studied on EOC patients' serum whole blood, healthy control (HC) serum, blood samples. Sixteen samples were collected compare miRNA analysis through microarray. According microarray results, one the dysregulated in hsa-let-7d-3p, validated by RT-qPCR discriminate two groups....
Recent studies have focused on the early detection of ovarian cancer (OC) using tumor materials by liquid biopsy. The mechanisms microRNAs (miRNAs) to impact OC and signaling pathways are still unknown. This study aims reliably perform functional analysis previously validated circulating miRNAs' target genes pathfindR. Also, overall survival pathological stage analyses were evaluated with which common in Cancer Genome Atlas GTEx datasets. Our previous three downregulated miRNAs...
MicroRNAs (miRNAs) are single-stranded RNA (20-23 bp) molecules which regulate expression of proteincoding gene by promoting mRNA degradation and translational inhibition in mammalians. The latest miRBase release (v20, June 2013) contains 24 521 microRNA loci from 206 species is processed to produce 30,424 mature products. miRNAs involved several mechanisms such as cardiovascular, central nervous system processes cancer. can be produced human placenta significant for placental development....
Personalized medicine is a relatively new and interesting concept in the medical healthcare industries. New approaches current research have supported search for biomarkers, based on genomic, epigenomic proteomic profile of individuals, using technological tools. This perspective involves potential to determine optimal interventions provide benefit-risk balance treatment, whilst it also takes patient's personal situation into consideration. Translational genomics, subfield personalized...
Objectives: P1A1/A2 polymorphism on Integrin Subunit Beta 3 (ITGB3) gene's correlation with increased risk of myocardial infarction (MI) is not clear and various researches have reported contradictory results concerning the ITGB3 gene. We focused relation MI, 26 male subjects under 45 years old who had MI. Due to increasing concern sudden death athletes, we compared these professional athletes. aimed investigate frequency polymorphism, in suffering elite athletes are at same age range....
Aim: Ovarian cancer (OC) is the most lethal gynecologic malignancy and frequently diagnosed at an advanced stage because of inadequate number biomarkers. Therefore, identification OC specific biological markers a vital step for diagnosis treatment response. Our goal to examine functional gene sets which are possibly ovarian their expression profiles in patients. We also aim determine potential genes therapeutic targets Method: The levels seven (FOS, FOSL2, JUN, MMP-2, MMP-9, TIMP-2, VEGFA)...
<div>AbstractPurpose:<p>We recently reported that the transcription factor NFATC4, in response to chemotherapy, drives cellular quiescence increase ovarian cancer chemoresistance. The goal of this work was better understand mechanisms NFATC4-driven chemoresistance.</p>Experimental Design:<p>We used RNA sequencing identify NFATC4-mediated differential gene expression. CRISPR-Cas9 and FST (follistatin)-neutralizing antibodies were assess impact loss function on cell...