A5057553860- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Lipid metabolism and disorders
- Parkinson's Disease Mechanisms and Treatments
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Ginkgo biloba and Cashew Applications
- Nerve injury and regeneration
- Chromatography in Natural Products
- Pharmacological Effects of Natural Compounds
- Supramolecular Self-Assembly in Materials
- Axon Guidance and Neuronal Signaling
- Autophagy in Disease and Therapy
- NF-κB Signaling Pathways
- Circadian rhythm and melatonin
- Metabolomics and Mass Spectrometry Studies
- Magnolia and Illicium research
- Birth, Development, and Health
- Hepatitis B Virus Studies
- Mitochondrial Function and Pathology
- RNA Interference and Gene Delivery
- Endoplasmic Reticulum Stress and Disease
Shanghai Sixth People's Hospital
2020-2022
Shanghai Jiao Tong University
2020-2022
Fudan University
2016-2019
Zhongshan Hospital
2016-2019
Wenzhou Medical University
2009
Zhejiang Taizhou Hospital
2009
Neuroinflammation-related amyloid-beta peptide (Aβ) accumulation after cerebral ischemia/reperfusion (I/R) accounts for I/R injuries and poststroke dementia. Recently, pyroptosis, a proinflammatory cell death, has been identified as crucial pathological link of injuries. However, whether pyroptosis acts trigger Aβ not yet demonstrated. Blood-brain barrier (BBB) glymphatic system mediated by aquaporin-4 (AQP-4) on astrocytic endfeet are important pathways the clearance in brain, especially...
Background: The dysfunctional blood-brain barrier (BBB)-glymphatic system is responsible for triggering intracerebral amyloid-beta peptide (Aβ) accumulation and acts as the key link between ischemic stroke dementia dominated by Alzheimer's disease (AD). Recently, pyroptosis in cerebral ischemia reperfusion (I/R) injury demonstrated a considerable mechanism causing BBB-glymphatic dysfunctions Aβ acute brain. Targeting glial to protect functions after I/R could offer new viewpoint prevent...
To explore the potential active components and corresponding target herb pairs of Radix Ginseng (Renshen) Bupleuri (Chaihu) in treatment nonalcoholic fatty liver disease (NAFLD) through network pharmacology vitro experiments.The targets pair Renshen Chaihu were screened a database system, Venn analysis was performed with obtained NAFLD targets. The intersecting analysed for gene ontology (GO) functions Kyoto Encyclopedia Genes Genome (KEGG) pathways, protein-protein interaction (PPI)...
We investigated the effects of Apocynum venetum leaf extract (AVLE) on depressive behaviors and neuronal apoptosis in a chronic unpredictable mild stress (CUMS) rat model depression. Rats were randomly divided into six groups: control, stress, fluoxetine, AVLE30, AVLE60, AVLE120. Except for control group, all rats submitted to paradigms four weeks induce behavior. Neuronal was assessed by terminal deoxynucleotidyl transferase- (TDT-) mediated dUTP-biotin nick end-labeling (TUNEL) method. The...
As a classical prescription of Traditional Chinese medicine, the Jia-Jian-Di-Huang-Yin-Zi (JJDHYZ) decoction has long been used to treat movement disorders. The present study evaluated effects JJDHYZ on dopaminergic (DA) neurons and their survival-enhancing microenvironment as well possible mechanisms involved using mouse model Parkinson's disease. In MPTP-lesioned mice, high dosage (34 g/kg/day) attenuated loss DA neurons, reversed dopamine depletion, improved expression glial-derived...
Bilobalide (BB), a constituent of the Ginkgo biloba extract, is neuroprotective agent with multiple mechanisms action. To further explore potential therapeutic effects BB in stroke, we investigated its on primary astrocytes using oxygen and glucose deprivation-reoxygenation (OGD-R) model. Cell viability was measured by lactate dehydrogenase release assay 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. death annexin 5 conjgated fluorescein isothiocyanate (V-FITC) assay,...
Abstract Stroke is a leading reason of death and long-term disability, most studies mainly focus on efforts to protect neurons. However, failed clinical trials suggest that therapies against single target in neurons may not be sufficient the involvement endothelial cells glial have been underestimated. Astrocytes are major source ApoE brain express high level receptors. Thus, mediate interaction between astrocytes cells. To address whether how ApoE-mediated astrocytes–endothelial contributes...
Abstract The pathogenesis of Alzheimer’s disease (AD) involves multiple cell types including endothelial cells, glia, and neurons. It suggests that therapy against single target in type may not be sufficient to treat AD therapies with protective effects more effective. Here, we comprehensively investigated the bilobalide on neuroinflammation Aβ degrading enzymes model mouse model. We find inhibits Aβ-induced STAT3-dependent expression TNF-α, IL-1β, IL-6 primary astrocyte culture. Bilobalide...
Amyloid-β peptide (Aβ) accumulation is a detrimental factor in cerebral ischemia/reperfusion (I/R) injuries accounting for dementia induced by ischemic stroke. In addition to blood brain barrier (BBB), the glymphatic system mediated aquaporin-4 (AQP-4) on astrocytic endfeet functions as an important pathway clearance of Aβ brain. Cerebral I/R pyroptosis potentially causes AQP-4 polarization loss and dysfunctional BBB-glymphatic exacerbating Aβ. Furthermore, toxicity has been identified...
Sheng-Di-Da-Huang Decoction was used as an effective hemostatic agent in ancient China. However, its therapeutic mechanism is still not clear. Inflammatory injury plays a critical role ICH-induced secondary brain injury. After hemolysis, hematoma components are released, inducing microglial activation via TLR4, which initiates the of transcription factors (such NF-κB) to regulate expression proinflammatory cytokine genes. This study aimed verify anti-inflammatory effects on ICH...
Guipi Tang (GPT) is a widely used traditional Chinese medicine that to treat major depressive disorder. However, the molecular mechanisms of its effects remain unclear.This study aimed investigate antidepressant-like GPT and explore underlying mechanisms.Male Sprague-Dawley rats were subjected chronic unpredictable mild stress (CUMS) procedure treated with various doses GPT, fluoxetine treatment as positive control. Behavioural tests (including sucrose preference test, novelty-suppressed...