A5075440583- Mechanisms of cancer metastasis
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Transcranial Magnetic Stimulation Studies
- Cancer Mechanisms and Therapy
- Lung Cancer Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Asthma and respiratory diseases
- Lung Cancer Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Ferrocene Chemistry and Applications
- Peptidase Inhibition and Analysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cell death mechanisms and regulation
- Functional Brain Connectivity Studies
- Cutaneous Melanoma Detection and Management
- Protease and Inhibitor Mechanisms
- Pain Management and Treatment
- Melanoma and MAPK Pathways
- Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Neonatal Respiratory Health Research
Carlo Forlanini Hospital
2012-2024
Harvard University
2001-2023
Hebrew SeniorLife
2021
Sapienza University of Rome
2019
Azienda Ospedaliera San Camillo-Forlanini
2019
American University of Beirut
2017
Berenson Allen Center for Noninvasive Brain Stimulation
2010-2016
Beth Israel Deaconess Medical Center
2001-2016
Clinica Luganese Moncucco
2016
Institut Guttmann
2014
Alzheimer's disease (AD) is associated with alterations in cortical perfusion that correlate cognitive impairment. Recently, neural activity the gamma band has been identified as a driver of arteriolar vasomotion while, on other hand, induction preclinical models AD shown to promote protein clearance and protection.
The pivotal role of neutrophils and macrophages in smoking-related lung inflammation COPD development is well-established. We aimed to assess whether sputum concentrations Human Neutrophil Peptides (HNP), Elastase (NE), Interleukin-8 (IL-8), Metalloproteinase-9 (MMP-9), major products macrophages, could be used trace airway progression towards pulmonary functional impairment characteristic COPD. Forty-two symptomatic smokers 42 patients underwent function tests; samples were collected at...
The pivotal role of neutrophils and macrophages in smoking-related lung inflammation COPD development is well-established. We aimed to assess whether sputum concentrations Human Neutrophil Peptides (HNP), Elastase (NE), Interleukin-8 (IL-8), Metalloproteinase-9 (MMP-9), major products macrophages, could be used trace airway progression towards pulmonary functional impairment characteristic COPD. Forty-two symptomatic smokers 42 patients underwent function tests; samples were collected at...
Microdeletions at exon 19 are the most frequent genetic alterations affecting Epidermal Growth Factor Receptor (EGFR) gene in non-small cell lung cancer (NSCLC) and they strongly associated with response to treatment tyrosine kinase inhibitors. A series of 116 NSCLC DNA samples investigated by Sanger Sequencing (SS), including 106 carrying EGFR deletions 10 without (control samples), were subjected deep next generation sequencing (NGS). All SS showed NGS. No seen control cases. In 93 (88%)...
Objective Two procedures for treating major depressive disorder were compared with regard to their respective effects on mood and cognition. Background Fourteen patients underwent treatment electroconvulsive therapy 14 repetitive transcranial magnetic stimulation. Patients tested three occasions: before initiation of treatment, at the end 2 weeks after treatment. Methods Electroconvulsive was applied unilaterally approximately times per week 4 weeks. Repetitive stimulation in sessions 1600...
PURPOSE The aim of the study was to define prognostic role metastasis suppressor gene, nm23, in 106 primary ovarian cancer patients. PATIENTS AND METHODS Northern and Western blotting analysis nm23-H1 nm23-H2 expression were performed a subset tumors. Immunohistochemical on formalin-fixed paraffin-embedded specimens from carcinomas by antihuman nm23 monoclonal antibody. RESULTS demonstrated direct association between levels. Moreover, an overall concordance 86.7% immunohistochemical data...
Background. Nm23 is a gene associated with low tumor metastatic potential and has been proposed to be metastasis suppressor gene. localized on chromosome 17q21.3–22, whereas the p53 17p13. Allelic deletions of 17 have related progression colorectal carcinomas. The purpose this study was analyze allelic in carcinomas assess their prognostic significance evolution patients. Methods. genes were studied 56 using different restriction fragment length polymorphisms. DNA ploidy proliferative...
Fas ligand (FasL) is a transmembrane protein that induces apoptosis (programmed cell death) in susceptible cells by interacting with its receptor, Fas. Transmembrane FasL cleaved metalloproteinase enzyme into soluble form released the extracellular medium. Tumors of Ewing's sarcoma family express functional and release FasL. This cleavage inhibited matrix inhibitor (MMPI). We therefore hypothesized MMPIs can lead to tumor inducing accumulation FasL.Ewing's neuroblastoma lines were treated...
Study Type – Therapy (individual cohort) Level of Evidence 2b What's known on the subject? and What does study add? Sorafenib is an oral receptor tyrosine kinase inhibitor that inhibits RAF serine/threonine kinases (vascular endothelial growth factor receptors 1, 2, 3 platelet‐derived factor‐beta, Flt‐3 c‐kit) are implicated in tumourigenesis tumour progression. approved for treatment advanced renal cell cancer. B‐RAF mutations (V600E K601E) may be interesting negative predictive markers...