A5066416124- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Reproductive System and Pregnancy
- Tuberculosis Research and Epidemiology
- Transgenic Plants and Applications
- Toxin Mechanisms and Immunotoxins
- HIV/AIDS Research and Interventions
- Mycobacterium research and diagnosis
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Plant Virus Research Studies
- Liver Disease Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral gastroenteritis research and epidemiology
- T-cell and Retrovirus Studies
- Chronic Myeloid Leukemia Treatments
- Herpesvirus Infections and Treatments
- Biotechnology and Related Fields
- Infectious Diseases and Tuberculosis
- vaccines and immunoinformatics approaches
- Vaccine Coverage and Hesitancy
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Parvovirus B19 Infection Studies
Immunitor (Mongolia)
2013-2019
Data Harbor (United States)
2015
Weatherford College
2007
Hadassah Medical Center
2005
Rajavithi Hospital
2003
Ministry of Public Health
2003
Thai Health Promotion Foundation
2002
New York University
1993-1997
Faculty of 1000 (United States)
1996
Columbia University Irving Medical Center
1993-1995
MAP30 (Momordica anti-HIV protein of 30 kDa) and GAP31 (Gelonium 31 are plant proteins that we have identified, purified, cloned from the medicinal plants Momordica charantia Gelonium multiflorum. These antiviral agents capable inhibiting infection HIV type 1 (HIV-1) in T lymphocytes monocytes as well replication virus already-infected cells. They not toxic to normal uninfected cells because they unable enter healthy also possess an N-glycosidase activity on 28S ribosomal RNA a topological...
Physical contact between latent HIV-infected monocytes and epithelial cells appears to trigger rapid assembly release of HIV into the enclosed space donor acceptor cells. During this process, form microvilli that intimately associate with membrane. HIVs sequestered in these sites are then internalized within phagocytic endosomes. Morphological evidence suggests parts virions fuse endosomal membrane escape cytoplasm epithelium before endosome-lysosome fusion. In addition, lysosomal...
We examined the effect of anti-HIV proteins MAP30 and GAP31, fromMomordica charantiaandGelonium multiflorum, on infection replication Herpes Simplex Viruses (HSV). Human lung WI-38 fibroblasts cultured in presence tenfold dilutions or GAP31 were exposed to HSV viral yield was measured at 24–48 hours by ELISA. The effective concentrations for 50% inhibition (EC50) 0.1–0.2 μM HSV-2, 0.3–0.5 HSV-1 respectively. In comparison, EC50for acyclovir (ACV), a commonly used anti-HSV drug, 0.2 1.6 HSV-2...
MAP30 is an antiviral protein from bitter melon (Momordica charantia). The enhancement of weak HIV antagonists, dexamethasone and indomethacin, by has been examined measuring the reduction in p24 expression acutely infected MT-4 lymphocytes. In presence 1.5 nM IC50 dose indomethacin lowered, without concurrent cytotoxicity, at least a thousand-fold to 10−7 M 10−8 M, respectively. This observation indicates that MAP30, multifunctional plant capable topological inactivation viral DNA specific...
GAP31 (gelonium anti-HIV protein of 31 kDa) is an which we have identified and purified from a medicinal plant, Gelonium multiflorum. It capable inhibiting HIV-1 infection replication. also exhibits DNA topoisomerase inhibitor activity RNA N-glycosidase activity. The ability to interrupt both functions may be related its multiple antiviral actions. To define the roles these activities in action GAP31, series peptides corresponding N-terminal segment were synthesized assayed for...
One-month Phase II trial was conducted in 43 sputum smear-positive patients with pulmonary tuberculosis randomized into treatment (n = 22) and placebo 21) arms to investigate the safety efficacy of an orally-administered therapeutic TB vaccine (V7) containing 10 μg heat-killed Mycobacterium vaccae provided by Longcom company. Immunotherapy control groups comprised 8 newly diagnosed (1stDx TB; 18.6%), 6 re-treated (RTB; 14%), 29 multidrug-resistant (MDR-TB; 67.4%) cases distributed at 5:4:13...
Immunotherapy of tuberculosis (TB) to shorten treatment duration represents an unmet medical need. Orally delivered, tableted TB vaccine (V7) containing heat-killed Mycobacterium vaccae (NCTC 11659) has been demonstrated in prior clinical studies be safe and fast-acting immune adjunct.The outcome Phase III trial V7 10 µg hydrolyzed M. was evaluated 152 patients randomized at 2:1 ratio: (N = 100), placebo 52). Both arms received conventional 1st or 2nd line drugs co-administered with daily...
Aim: A 1-month Phase II trial was conducted in 41 patients with pulmonary TB who were randomized into treatment (n = 20) and placebo 21) arms to investigate the safety efficacy of an orally-administered therapeutic vaccine (V7) containing 10 µg heat-killed Mycobacterium vaccae provided by Immodulon Therapeutics Ltd (London, UK). Materials & methods: Both received conventional anti-TB therapy administered along a daily pill V7 or placebo. The subject population had four categories TB:...
Indomethacin, a common non‐steroidal anti‐inflammatory drug (NSAID), has been used to treat rheumatoid arthritis. Although indomethacin also as an immunopotentiator and symptomatic NSAID in AIDS, its effect on HIV replication is unknown. MT‐4 lymphocytes were inoculated with the presence of tested for p24 expression by ELISA. The 50% inhibition (IC 50 ) was 10 μM, corresponding plasma levels after administration mg oral indomethacin. antiviral appears be specific since no toxicity observed...
Human chorionic gonadotropin (hCG)--a pregnancy-associated immunomodulating hormone--has been recently shown in vitro to suppress reverse transcriptase activity chronically HIV-infected lymphocytes and monocytes block viral transmission resulting from cell-cell contact between virus-carrying placental trophoblasts. In further pursuit of the query into mechanism action, purified alpha beta subunits hCG were tested for inhibition p24 gag protein synthesis virus-producing ACH-2 U1 monocytes....
Placebo-controlled, randomized, phase 2b trial was conducted in 34 adults comprising 18 first-diagnosed (52.9%), 6 relapsed (17.6%), and 10 MDR-TB (29.4%) cases to investigate the safety efficacy of an oral immune adjunct (V5). The immunotherapy (N = 24) placebo 10) arms received once-daily tablet V5 or for one month addition conventional anti-TB therapy (ATT) administered under directly observed (DOT).The enlarged liver, total bilirubin, erythrocyte sedimentation rate, lymphocyte leukocyte...
It has been demonstrated that human chorionic gonadotropin (hCG) inhibits HIV production in vitro, suggesting this soluble placental glycoprotein can control viral replication and spread vivo. hCG--the major product of fetal trophoblasts--was tested on an vitro model consisting choriocarcinoma-derived ENAMI trophoblasts exposed to HIV-infected MOLT-4 lymphocytes. The results show a U-shaped antiviral dose-effect suggest hCG may contribute protection against intrauterine transmission HIV-1.
This Phase IIb, placebo-controlled study involved 55 TB patients treated with anti-TB therapy. They were divided into two groups, matched by age, gender, baseline bodyweight and clinical manifestations: one group (n = 27) received a once-daily V-5 Immunitor (V5) immunotherapy pill the other 28) placebo. Only (3.7%) three (10.7%) subjects in V5 placebo arms, respectively had first-diagnosed, drug-sensitive TB; remaining re-treated TB, multidrug-resistant or HIV-TB coinfection. After 1 month,...