A5026539856- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Preterm Birth and Chorioamnionitis
- Congenital Diaphragmatic Hernia Studies
- Hemoglobinopathies and Related Disorders
- Prenatal Screening and Diagnostics
- Iron Metabolism and Disorders
- Congenital Heart Disease Studies
- Sarcoma Diagnosis and Treatment
- Pregnancy and Medication Impact
- Renal and related cancers
- Ectopic Pregnancy Diagnosis and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Gestational Trophoblastic Disease Studies
- Congenital heart defects research
- Cardiovascular Issues in Pregnancy
- Gestational Diabetes Research and Management
- Urological Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Eosinophilic Esophagitis
- Vascular Malformations and Hemangiomas
- Soft tissue tumor case studies
- Renal cell carcinoma treatment
University of Rochester Medical Center
2016-2025
University of Rochester
2013-2024
Emory University Hospital
2021
Strong Memorial Hospital
2019
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2016
University of Utah
2013
University of North Carolina at Chapel Hill
2013
Harvard University
1988-2002
Boston Children's Hospital
2002
University Surgical Associates
1998
Maternalfloor infarction (MFI) is a poorly understood placental lesion reportedly associated with intrauterine growth restriction (IUGR) and recurrence. In this study of MFI the related disorder, massive perivillous fibrin deposition (MFD), semiquantitative histologic criteria for these diagnoses are defined rates IUGR recurrence assessed. Pathologic slides 80 placentas diagnosed as or MFD at Brigham Women’s Hospital (1989–99) were reviewed reclassified classic MFI, transmural MFD,...
The organization and physical linkage of four members a major complement locus, the RCA have been determined using technique pulsed field gradient gel electrophoresis in conjunction with Southern blotting. genes encoding CR1, CR2, DAF, C4bp were aligned that order within region 750 kb. In addition, 5' to 3' orientation CR1 gene (5' proximal CR2) was 5'- 3'-specific DNA probes. proximity these may be related structural functional homologies protein products. Overall, restriction map including...
Abstract Metatropic dysplasia is a clinical heterogeneous skeletal characterized by short extremities, trunk with progressive kyphoscoliosis, and craniofacial abnormalities that include prominent forehead, midface hypoplasia, squared‐off jaw. Dominant mutations in the gene encoding TRPV4, calcium permeable ion channel, were identified all 10 of series metatropic cases, ranging severity from mild to perinatal lethal. These data demonstrate lethal form disorder dominantly inherited suggest...
Human lung morphogenesis begins by embryonic life and continues after birth into early childhood to form a complex organ with numerous morphologically functionally distinct cell types. Pulmonary organogenesis involves dynamic changes in proliferation, differentiation, migration of specialized cells derived from diverse lineages. Studying the molecular cellular processes underlying formation fully functional requires isolating pulmonary populations during development. We now report novel...
Bronchopulmonary dysplasia (BPD) is a disease of prematurity related to the arrest normal lung development. The objective this study was better understand how proteome modulation and cell-type shifts are noted in BPD pathology. Pediatric human donors aged 1-3 yr were classified based on history histopathology consistent with "healed" (hBPD, n = 3) "established" (eBPD, compared respective full-term born (n 6) age-matched term controls. Proteins quantified by tandem mass spectroscopy selected...
To estimate the percentage of deliveries eligible for pathologic examination placenta and compare with observed practice using College American Pathologists' (CAP) 1997 guidelines placenta.Records were reviewed from all live-birth 20 weeks or more gestation in 2001 at Strong Memorial Hospital. The expected number CAP recommended indications was determined compared which actually examined. Descriptive statistics, independent t tests, chi(2) difference between two population proportions test,...
Maternal T cells and fetal macrophages constitute the primary infiltrate of chronic villitis unknown etiology (CVUE), but role CD25 + /FOXP3 regulatory (Treg) in CVUE has not been examined. Moreover, little is known about expression immune markers, such as major histocompatibility complex (MHC) class II antigen, human leukocyte antigen–DR (HLA-DR), trophoblasts this disease. We, therefore, examined placentas for presence Treg aberrant activation HLA-DR trophoblasts. Sequential...
Background: Chorionic histiocytic hyperplasia (CHH) is a chronic inflammatory lesion (CIL) with linear infiltrate of fetal histiocytes in the base or membranous chorion. We performed retrospective study placentas diagnosed since our last period order to analyze strength association CHH other CIL. Methods: Third trimester were identified LIS. Comparisons incidence associated lesions, including villitis (CV), deciduitis (CD), chorioamnionitis (CC), eosinophilic/T-cell chorionic vasculitis...
Eosinophilic/T-cell chorionic vasculitis (ETCV) is characterized by mixed T-cell, eosinophilic, and histiocytic infiltrates within the vessel wall. We sought to better characterize this lesion with respect other pathologic correlates T-cell populations involved. Epidemiologic data diagnoses, including concurrent chronic villitis (CV), were tabulated for each case of ETCV diagnosed at our institution over a 6-year period. CD3, CD25, FOXP3, dual FOXP3-CD3 immunostains used identify regulatory...
Behavioral issues are a frequent problem in the pediatric population. Often, these evaluated and considered to be psychiatric origin. We report on patient who presented with severe behavioral disturbance developed organic symptoms including hypoventilation dysautonomia was ultimately diagnosed ROHHADNET syndrome, syndrome of rapid-onset obesity, hypothalamic dysfunction, hypoventilation, autonomic dysregulation associated neuroendocrine tumor. Autopsy findings revealed novel encephalitis.
Autism Spectrum Disorder (ASD) is one of the fastest-growing developmental disorders in United States. It was hypothesized that variations placental chorionic surface vascular network (PCSVN) structure may reflect both overall effects genetic and environmentally regulated branching morphogenesis within conceptus fetus' vital organs. This paper provides sound evidences to support study ASD risks with PCSVN through a combination feature-selection classification algorithms. Twenty eight...
This study investigates the hypotheses that (1) fetal inflammatory response to intra-amniotic infection can occur in early stages of maternal and (2) a difference cord inflammation exists at different sites cord. Placentas accessioned our department over 4-year period with differential umbilical vessel between proximal distal sections were evaluated for using 0 4 graded scale. Cases also acute chorionic vasculitis extent response. Of 5566 placentas, 1004 (18%) had some degree inflammation;...
Spontaneous massive retroperitoneal hemorrhage from an adrenal gland is a rare event. A thoughtful and meticulous approach to such patient, with appropriate diagnostic studies, ICU surgical care are essential for patient survival. In patients active bleeding, angiographic embolization valuable adjunct achieve hemostasis, allow further work-up of the tumor, improved subsequent oncologic resection. Hemodynamically unstable patients, however, may require supportive transfusions in intensive...