A5083440460- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Nitric Oxide and Endothelin Effects
- Neonatal and Maternal Infections
- Fluid Dynamics Simulations and Interactions
- Fire Detection and Safety Systems
- Cardiac Ischemia and Reperfusion
- Material Properties and Applications
- Congenital Heart Disease Studies
- Environmental and Industrial Safety
- Immune Response and Inflammation
- Neuroscience of respiration and sleep
- Inflammatory mediators and NSAID effects
- Heart Rate Variability and Autonomic Control
- Combustion and Detonation Processes
- Soil Mechanics and Vehicle Dynamics
- Eicosanoids and Hypertension Pharmacology
- Renal function and acid-base balance
University of Virginia
1999
Temple University
1994-1998
St. Christopher's Hospital for Children
1994-1998
Physiol (Belgium)
1996
The University of Texas Health Science Center at Tyler
1996
Bryn Mawr College
1996
Wolfson, Marla R., Nancy E. Kechner, Robert F. Roache, Jean-Pierre DeChadarevian, Helena Friss, S. David Rubenstein, and Thomas H. Shaffer. Perfluorochemical rescue after surfactant treatment: effect of perflubron dose ventilatory frequency. J. Appl. Physiol. 84(2): 624–640, 1998.—To test the hypotheses that perfluorochemical (PFC) liquid natural (SF) treatment would improve pulmonary function histology this profile be influenced by PFC or ventilator strategy, anesthetized preterm lambs ( n...
Background Nonselective nitric oxide synthase (NOS) inhibition has detrimental effects in sepsis because of the physiologically important endothelial NOS (eNOS). The authors hypothesized that selective inducible (iNOS) would maintain eNOS vasodilation but prevent acetylcholine- and bradykinin-mediated vasoconstriction caused by lipopolysaccharide-induced dysfunction. Methods Rats were administered intraperitoneal lipopolysaccharide (15 mg/kg) with without iNOS inhibitors...
The use of neat perfluorochemical liquid (PFC) as an alternative respiratory medium has gained increasing attention for assessment and treatment the immature or injured lung. In vitro in vivo plain film computed tomographic (CT) studies were performed on small large animals to evaluate perfluorooctylbromide (perflubron) a bronchographic contrast agent quantitate distribution elimination this fluid from lung following total ventilation during gas breathing after tracheal instillation...
We studied the effect of rescue therapy with modified porcine surfactant (Curosurf®) or brief perfluorocarbon liquid ventilation on pulmonary gas exchange, mechanics and structure in very immature lambs. Both strategies produced an improvement arterial oxygenation were able to support CO<sub>2</sub> elimination. Histology showed unevenly inflated lungs all but tidal-liquid-ventilated speculate that due lung architecture relatively high permeability, previous exposure impeded full...
S413 INTRODUCTION: Acetylcholine (ACh) exhibits vasoconstrictive properties in isolated rat lungs exposed to lipopolysaccharide (LPS) [1]. We hypothesized that changes endothelial and muscarinic receptors function associated with vasoconstriction are due cyclooxygenase products [2,3]. MATERIAL AND METHODS: This study was approved by the animal research committee of University Virginia. Male Sprague-Dawley rats (250-350g) were divided into 4 groups (n=4-5). 3 hours before lung isolation,...