A5033175999- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Mechanical Circulatory Support Devices
- Infant Development and Preterm Care
- Cardiovascular and Diving-Related Complications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Function and Risk Factors
- Inhalation and Respiratory Drug Delivery
- Thermal Regulation in Medicine
- Heart Failure Treatment and Management
- Anesthesia and Neurotoxicity Research
- Nitric Oxide and Endothelin Effects
- Respiratory viral infections research
- Congenital Heart Disease Studies
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Burn Injury Management and Outcomes
- Birth, Development, and Health
- Congenital heart defects research
- Asthma and respiratory diseases
Thomas Jefferson University
1993-2025
Temple University
2013-2022
Temple Lung Center
2010-2020
Thoracic Surgery Foundation
2018-2019
Temple University Hospital
1991-2016
The Centers
2015
University of Pennsylvania
1984-2014
Alfred I. duPont Hospital for Children
2002-2012
Physiol (Belgium)
1996-2011
Arcadia
2010
The intratracheal administration of a perfluorocarbon liquid during continuous positive-pressure ventilation (partial ventilation) improves lung function in animals with surfactant deficiency. Whether partial is effective the treatment infants severe respiratory distress syndrome not known.
Alveolar epithelium plays a pivotal role in protecting the lungs from inhaled infectious agents. Therefore, regenerative capacity of alveolar is critical for recovery these insults order to rebuild epithelial barrier and restore pulmonary functions. Here, we show that sublethal infection mice with Streptococcus pneumoniae, most common pathogen community-acquired pneumonia, led exclusive damage lung alveoli, followed by regeneration resolution inflammation. We surfactant protein C–expressing...
In the clinical setting, nasal cannulas are frequently used to deliver supplemental oxygen neonates and not believed affect general respiratory status. contrast, it was hypothesized that changes associated with cannula gas flow may be related in part generation of positive end-distending pressure. To test this hypothesis, alterations esophageal pressure were quantified as an indication thoracoabdominal motion breathing patterns 13 preterm infants at levels 0.5, 1, 2 L/min delivered by outer...
To differentiate the effects of gas and liquid ventilation on cardiopulmonary function during early development, we compared clinical, physiological, histological profiles gas- liquid-ventilated preterm lambs (n = 16; 108–116 days gestation). Immediately after cesarean section delivery, commenced using delivered by a volume ventilator 9) or perfluorochemical 7) mechanically assisted system. Pulmonary exchange, acid-base status, vital signs, respiratory compliance were assessed 3-h protocol;...
Histone deacetylase inhibition counteracts adverse left ventricular remodeling, improves pulmonary function, and reverses diastolic dysfunction.
The authors evaluated gas exchange, pulmonary function, and lung histology during perfluorocarbon liquid ventilation (LV) when compared with (GV) in the setting of severe respiratory failure.The efficacy LV failure has been premature animals surfactant deficiency. However, very little work performed evaluating older animal models adult distress syndrome (ARDS).A stable model injury was induced 12 young sheep weighing 16.4 +/- 3.0 kg using right atrial injection 0.07 mL/kg oleic acid followed...
Thoracoabdominal asynchrony (TAA) has long been thought clinically useful in the assessment of airflow obstruction (AO) infants. To test hypothesis that measurement TAA is lung mechanics infants with AO, we have used respiratory inductive plethysmography (RIP) to quantify TAA. We compared changes before and after aerosolized bronchodilator (BD) administration 13 Abdominal wall (AB) rib cage (RC) motion were displayed on an X-Y recorder a Lissajous figure. Asynchrony between RC AB was...
The studies presented here indicate that activation of the complement (C′) system by a foreign protein will cause membrane injury and passive lysis unsensitized erythrocytes present at time reaction. These observations suggest in addition to classical antibody-C′-induced cytolysis, there are alternative pathways or mechanisms for participation terminal C′ components production cell injury. We have shown substance derived from cobra venom eluted single band on polyacrylamide can promote...
To determine the influence of body position on chest wall and pulmonary function, we studied ventilatory, mechanics, thoracoabdominal motion profiles in 20 preterm infants recovering from respiratory disease who were positioned both supine prone position. Thoracoabdominal was assessed measurements relative rib cage abdominal movement calculated phase angle (an index synchrony) abdomen Lissajous figures. The ventilatory function simultaneous transpulmonary pressure, airflow, tidal volume....
Abstract We obtained maximal partial expiratory flow‐volume (PEFV) curves using the rapid compression technique in three infants with intrathoracic tracheomalacia. Maximum flows were quantitated at functional residual capacity (V̇maxFRC). Studies performed baseline, after inhalation of methacholine (MCh) and albuterol. At all patients had significantly lower than normal V̇maxFRC values, two displayed flow limitation during tidal breathing. improved MCh administration, but fell back toward or...
Objective To investigate the effects of lung lavage with oxygenated liquid perfluorochemical on gas exchange, mechanics, and cardiac function in animals acute injury. Design Prospective, randomized, controlled trial. Setting Animal laboratory. Subjects Eight adult cats (2 to 4 kg, random sex). Interventions Two insults were combined cause injury: oleic acid infusion saline whole-lung wash. Animals assigned either control or treatment group which consisted a (Rimar 101) lavage....
Abstract Thoracoabdominal motion (TAM) profiles were determined in ten infants requiring nasal continuous positive airway pressure (CPAP) and supplemental oxygen, order to assess the influence of CPAP on chest wall function with respiratory insufficiency. was quantitated by inductive plethysmography, measuring relative rib cage abdomen. Baseline pulmonary (without support) assessed from simultaneous measurements transpulmonary pressure, air flow, tidal volume. Measurements acquired at...
Rationale Alveolar type II (ATII) cells act as adult stem contributing to alveolar I (ATI) cell renewal and play a major role in idiopathic pulmonary fibrosis (IPF), supported by familial cases harbouring mutations genes specifically expressed these cells. During IPF, ATII lose their regenerative potential aberrantly express pathways epithelial–mesenchymal transition (EMT). The microRNA miR-200 family is downregulated but its effect on human IPF remains unproven. We wanted 1) evaluate the...
Evidence of surfactant inactivation by meconium has led to the use exogenous therapy in management aspiration syndrome (MAS). Liquid assisted ventilation been shown improve cardiopulmonary function lungs with high surface tension. We compared liquid experimental acute injury. Thirty-two newborn lambs were ventilated at peak inspiratory pressures 13–16 cm H2O, positive end expiratory pressure 3–4 fractional inspired oxygen concentration (F1O2) 1.0, and a respiratory frequency range between 30...
Therapeutic management of respiratory distress syndrome, pneumonia, and pulmonary hypertension includes delivery biologically active agents to the neonatal lung. However, mechanical abnormalities lung, intrapulmonary shunting, ventilation-perfusion mismatching, elevated surface tension impede effective systemic or intratracheal lung during conventional gas ventilation. The objective this study was test hypothesis that perfluorochemical (PFC) liquid ventilation can be used for administration...
Wolfson, Marla R., Nancy E. Kechner, Robert F. Roache, Jean-Pierre DeChadarevian, Helena Friss, S. David Rubenstein, and Thomas H. Shaffer. Perfluorochemical rescue after surfactant treatment: effect of perflubron dose ventilatory frequency. J. Appl. Physiol. 84(2): 624–640, 1998.—To test the hypotheses that perfluorochemical (PFC) liquid natural (SF) treatment would improve pulmonary function histology this profile be influenced by PFC or ventilator strategy, anesthetized preterm lambs ( n...