A5022310299- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Diaphragmatic Hernia Studies
- Hemoglobinopathies and Related Disorders
- Asthma and respiratory diseases
- Iron Metabolism and Disorders
- Cystic Fibrosis Research Advances
- Neuroscience of respiration and sleep
- Child and Adolescent Health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inhalation and Respiratory Drug Delivery
- Airway Management and Intubation Techniques
- Pleural and Pulmonary Diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Respiratory and Cough-Related Research
- Transplantation: Methods and Outcomes
- Neurogenetic and Muscular Disorders Research
- Hematopoietic Stem Cell Transplantation
- Respiratory viral infections research
- Esophageal and GI Pathology
- Streptococcal Infections and Treatments
- Dysphagia Assessment and Management
- Infant Development and Preterm Care
- Tracheal and airway disorders
Children's Hospital of Philadelphia
2015-2025
University of Pennsylvania
2013-2024
Philadelphia University
2004-2024
Eastern Washington University
2024
Indiana University School of Medicine
2016
Massachusetts General Hospital
2016
Guy's and St Thomas' NHS Foundation Trust
2016
King's College London
2016
National Cancer Institute
2016
Pulmonary Associates
2016
Asthma is a complex disease that has genetic and environmental causes. The factors associated with susceptibility to asthma remain largely unknown.
Development of chest wall stiffness between infancy and adulthood has important consequences for respiratory system function. To test the hypothesis that there is substantial stiffening in first few years life, we measured passive compliance (Cw) 40 sedated humans 2 wk-3.5 yr old. Respiratory muscles were relaxed with manual ventilation applied during Mead-Whittenberger technique. (Crs) lung (Cl) calculated from airway opening pressure, transpulmonary tidal volume. Cw was as 1/Cw = 1/Crs -...
Thoracoabdominal asynchrony (TAA) has long been thought clinically useful in the assessment of airflow obstruction (AO) infants. To test hypothesis that measurement TAA is lung mechanics infants with AO, we have used respiratory inductive plethysmography (RIP) to quantify TAA. We compared changes before and after aerosolized bronchodilator (BD) administration 13 Abdominal wall (AB) rib cage (RC) motion were displayed on an X-Y recorder a Lissajous figure. Asynchrony between RC AB was...
Section:ChooseTop of pageAbstract <<Summary Recommendation...IntroductionUse These GuidelinesDefinition PPRDMethodsResultsLimitations and Future Re...ConclusionsReferencesCITING ARTICLES
Abstract Background Filamentous fungi are prolific producers of bioactive molecules and enzymes with important applications in industry. Yet, the vast majority fungal species remain undiscovered or uncharacterized. Here we focus our attention to a wild isolate that identified as Anthostomella pinea . The fungus belongs complex polyphyletic genus family Xylariaceae , which is known comprise endophytic pathogenic produce plethora interesting secondary metabolites. Despite that, largely...
To determine the influence of body position on chest wall and pulmonary function, we studied ventilatory, mechanics, thoracoabdominal motion profiles in 20 preterm infants recovering from respiratory disease who were positioned both supine prone position. Thoracoabdominal was assessed measurements relative rib cage abdominal movement calculated phase angle (an index synchrony) abdomen Lissajous figures. The ventilatory function simultaneous transpulmonary pressure, airflow, tidal volume....
Abstract Asynchronous or paradoxic motion between the rib cage and abdomen may be seen in infants with lung disease. We have recently shown that after bronchodilator administration, degree of asynchrony decreases proportionately to improvement mechanics. However, whether such thoraco‐abdominal (TAA) is a useful indicator function cross‐sectional population, i.e., correlates baseline mechanics, unknown. Therefore, we quantitated TAA using respiratory inductive plethysmography during quiet...
Section:ChooseTop of pageAbstract <<IntroductionMethodsResultsACSLower Airway Disease and ...SDB HypoxemiaPulmonary Vascular Compli...FUTURE DIRECTIONSSUMMARYReferencesCITING ARTICLES
Oxyhemoglobin desaturation in patients with sickle cell disease has been proposed as a possible mechanism the initiaton of vasco-occlusive pain crises. Nocturnal oxyhemoglobin (NOD) described prevalence up to 40% children and adolescents disease. The objective this study was evaluate mechanisms nocturnal determine role obstructive sleep apnea. We performed 16-channel polysomnograms pulmonary function testing 20 (ages 7–21 years) who had documented on home oximetry studies. median saturation...
Studies in urban emergency departments (EDs) have found poor quality of chronic asthma care and identified beliefs barriers associated with low rates follow-up a primary provider (PCP).To develop an ED-based intervention including symptom screening, video addressing mailed reminder; measure the effect on PCP asthma-related outcomes.This randomized, controlled trial enrolled children aged 1 to 18 years who were discharged after treatment pediatric ED. Control subjects received instructions...
To describe the rate, distribution and correlates of periodic limb movements in sleep (PLMS) children with sickle cell disease (SCD).Prospective, cross-sectional.Hospital-based laboratory.Sixty-four aged 2-18 years SCD, hemoglobin SS-type who had an overnight polysomnogram a parent-completed Pediatric Sleep Questionnaire. Mean age was 8.4 (SD 4.8); 50% were male.N/A.The mean PLMS index 3.7 (6.6) ranged from 0 to 31.8, 23.4% sample having ≥ 5/h. efficiency decreased (P = 0.03), total arousal...