A5077825835- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Immune Response and Inflammation
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Macrophage Migration Inhibitory Factor
- Signaling Pathways in Disease
- Seaweed-derived Bioactive Compounds
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Trypanosoma species research and implications
- Viral Infections and Vectors
- Systemic Lupus Erythematosus Research
- Extracellular vesicles in disease
- COVID-19 Clinical Research Studies
- Inflammatory mediators and NSAID effects
- Malaria Research and Control
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Natural product bioactivities and synthesis
- Chemokine receptors and signaling
- S100 Proteins and Annexins
- Vitamin C and Antioxidants Research
- Protein Kinase Regulation and GTPase Signaling
- Exercise and Physiological Responses
- Liver Disease Diagnosis and Treatment
- Galectins and Cancer Biology
Queen Mary University of London
2015-2025
Innovate UK
2025
William Harvey Research Institute
2015-2022
Trinity College Dublin
2018
Royal College of Surgeons in Ireland
2018
Universidade Federal de Minas Gerais
2008-2011
Neutrophils generate chrondroprotective AnxA1-containing microvesicles that enter immune cell–impenetrable cartilage.
Specialized pro-resolving mediators (SPM-lipoxins, resolvins, protectins, and maresins) are produced via the enzymatic conversion of essential fatty acids, including omega-3 acids docosahexaenoic acid n-3 docosapentaenoic acid. These exert potent leukocyte directed actions control vascular inflammation. Supplementation animals humans with in particular exerts protective reducing systemic Of note, mechanism(s) activated by these supplements exerting their remain poorly understood.Given that...
Dengue is a mosquito-borne disease caused by one of four serotypes virus (DENV-1-4). Severe dengue infection in humans characterized thrombocytopenia, increased vascular permeability, hemorrhage and shock. However, there little information about host response to DENV infection. Here, mechanisms accounting for IFN-γ production effector function during were investigated murine model DENV-2 expression was greatly after mice its preceded increase IL-12 IL-18 levels. In IFN-γ(-/-) mice,...
Abstract Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid arthritis (RA), we observe that peripheral blood specialized pro-resolving (SPM) concentrations linked both DMARD responsiveness pathotype. Machine learning analysis demonstrates baseline plasma resolvin D4, 10S, 17S-dihydroxy-docosapentaenoic acid, 15R-Lipoxin (LX)A 4 n-3...
Diurnal mechanisms are central to regulating host responses. Recent studies uncovered a novel family of mediators termed as specialized proresolving that terminate inflammation without interfering with the immune response.Herein, we investigated diurnal regulation in humans and their role controlling peripheral blood leukocyte platelet activation.Using lipid mediator profiling healthy volunteers, found plasma concentrations n-3 docosapentaenoic acid-derived D-series resolvins (RvDn-3 DPA)...
Rationale: Resolution mechanisms are central in both the maintenance of homeostasis and return to catabasis following tissue injury infections. Among proresolving mediators, essential fatty acid-derived specialized lipid mediators (SPM) govern immune responses limit disease severity. Notably, little is known about relationship between expression activity SPM pathways, circulating phagocyte function severity patients infected with novel severe acute respiratory syndrome coronavirus 2 leading...
Macrophages are central in orchestrating the clearance of apoptotic cells and cellular debris during inflammation, with mechanism(s) regulating this process remaining interest. Herein, we found that n-3 docosapentaenoic acid-derived protectin (PDn-3 DPA) biosynthetic pathway regulated differentiation human monocytes, altering macrophage phenotype, efferocytosis, bacterial phagocytosis. Using lipid mediator profiling, primary recombinant enzymes 15-lipoxygenases initiate PDn-3 DPA catalyzing...
While new treatments have been developed to control joint disease in rheumatoid arthritis, they are partially effective and do not promote structural repair of cartilage. Following an initial identification α-1-Antitrypsin (AAT) during the resolution phase acute inflammation, we report here properties this protein context cartilage protection, associated pain behavior. Intra-articular systemic administration AAT reversed nociception, degradation KBxN serum neutrophil elastase models...
Dietary supplements have improved performance and muscle hypertrophy in athletes nonathletes the past few decades. Theracurmin, a nutraceutical supplement based on curcumin, has been highlighted by its anti-inflammatory antioxidant properties physiological pathological conditions. This study aimed to investigate effects of theracurmin intake (300 mg/kg), containing 30 mg/kg male Swiss mice ( n = 66) under distinct protocols climbing stairs (strength exercise) their respective detraining...
Rheumatoid arthritis is an inflammatory condition characterized by overzealous inflammation that leads to joint damage and associated with increased incidence of cardiovascular disease. Statins are frontline therapeutics for patients disease exert beneficial actions in rheumatoid arthritis. The mechanism mediates the statins remains interest. In present study, we found administration 2 clinically relevant statins—atorvastatin (0.2 mg/kg) or pravastatin mg/kg)—to mice during up-regulated...
Abstract Galectin-3 has been associated with a plethora of proinflammatory functions because its ability, among others, to promote neutrophil activation and the reduction in recruitment models infection Gal-3-null mice. Conversely, it also linked resolution inflammation through actions as an opsonin ability efferocytosis apoptotic neutrophils. Using self-resolving model peritonitis, we have addressed modulation role Gal-3 acute inflammation. We shown that expression is increased neutrophils...
G-protein-coupled receptor 40 (GPR40) is known to play a role in the regulation of fatty acids, insulin secretion and inflammation. However, function this human neutrophils, one first leukocytes arrive at site infection, remains be fully elucidated. In present study, we demonstrate that GPR40 upregulated on activated neutrophils investigated functional effects upon treatment with selective agonist; GW9508. Interestingly, expression was up-regulated after neutrophil stimulation...
Chagas’ disease is caused by Trypanosoma cruzi infection and characterized chronic fibrogenic inflammation heart dysfunction. Chemokines are produced during drive tissue inflammation. In rats, acute intense myocarditis regression of after control parasitism. We investigated the role CCL3 CCL5 using DNA vaccination encoding for each chemokine separately or simultaneously. MetRANTES treatment was used to evaluate CCR1 CCR5, receptors CCL5. Vaccination with increased parasitism decreased local...
ABSTRACT The plasma level of the chemokine CCL3 is elevated in patients with chronic severe schistosomiasis mansoni. We have previously shown that −/− mice experimental infection showed diminished pathology and worm burden compared to those wild-type (WT) mice. To elucidate further role CC chemokines during mansoni infection, we evaluated course C57BL/6J deficient CCR5, one receptors for CCL3. CCR5 deficiency proved be remarkably deleterious host, since mortality rates reached 70% at 14...
Biomolecular investigations using synthetic ePD<sub>n-3 DPA</sub>have been performed to study its role in the biosynthesis of specialized pro-resolving mediator PD1<sub>n-3 DPA</sub>.