A5052029675- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Renal Diseases and Glomerulopathies
- Radiation Dose and Imaging
- Immunodeficiency and Autoimmune Disorders
- Urticaria and Related Conditions
- Pharmacological Effects and Toxicity Studies
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Neuroendocrine Tumor Research Advances
- Effects of Radiation Exposure
- Lung Cancer Treatments and Mutations
- Diabetes and associated disorders
- Lanthanide and Transition Metal Complexes
- Pituitary Gland Disorders and Treatments
- Radiology practices and education
- Electrolyte and hormonal disorders
- Pediatric health and respiratory diseases
- Congenital gastrointestinal and neural anomalies
- Diet and metabolism studies
- Advanced X-ray and CT Imaging
- Mass Spectrometry Techniques and Applications
- Pregnancy and Medication Impact
- Cerebral Venous Sinus Thrombosis
- Congenital limb and hand anomalies
Erasmus MC
2022-2025
Erasmus MC Cancer Institute
2022-2025
Massachusetts General Hospital
2024
Boston University
2024
Harvard University
2024
Erasmus University Rotterdam
2024
Belgian Nuclear Research Centre
2017-2023
Polytechnic University of Turin
2016
Targeting the prostate-specific membrane antigen (PSMA) using lutetium-177-labeled PSMA-specific tracers has become a very promising novel therapy option for prostate cancer (PCa). The efficacy of this might be further improved by replacing β-emitting lutetium-177 with α-emitting actinium-225. Actinium-225 is thought to have higher therapeutic due high linear energy transfer (LET) emitted α-particles, which can increase amount and complexity induced DNA double strand breaks (DSBs). Here we...
Survival and linear-quadratic model fitting parameters implemented in treatment planning for targeted radionuclide therapy depend on accurate cellular dosimetry. Therefore, we have built a refined dosimetry [177Lu]Lu-DOTA-[Tyr3]octreotate (177Lu-DOTATATE) vitro experiments, accounting specific cell morphologies sub-cellular radioactivity distributions.Time activity curves were measured modeled medium, membrane-bound, internalized fractions over 6 days. Clonogenic survival assays performed at...
PurposeTo evaluate the effectiveness of currently available radioprotective (RP) devices in reducing dose to interventional cardiology staff, especially eye lens and brain.MethodsThe performances five RP (masks, caps, patient drapes, staff lead lead-free aprons Zero-Gravity (ZG) suspended radiation protection system) were assessed by means Monte Carlo (MC) simulations. A geometry representative an setup was modelled several configurations, including beam projections distance from source,...
This study investigates the radiobiology of peptide receptor radionuclide therapy (PRRT) using clinically relevant cancer cell lines by developing a framework for realistic cellular dosimetry in 2- and 3-dimensional cluster-forming configurations. Methods: The radiobiologic responses GOT1 NCI-H69 tumor to PRRT external beam radiotherapy (EBRT) were compared. Viability at 7 d death multiple time points assessed. Image-based multicellular models developed reflect vitro exposure complexity...
<b>Rationale:</b> To build a refined dosimetry model for [<sup>177</sup>Lu]Lu-DOTA-[Tyr<sup>3</sup>]octreotate (<sup>177</sup>Lu-DOTATATE) <i>in vivo</i> experiments enabling the correlation of absorbed dose with double strand breaks (DSBs) induction and cell death. <b>Methods:</b> Somatostatin receptor type-2 (SSTR<sub>2</sub>) expression NCI-H69 xenografted mice, injected <sup>177</sup>Lu-DOTATATE, was imaged at 0, 2, 5, 11 days. This used as input to reconstruct realistic 3 dimensional...
. To allow the estimation of secondary cancer risks from radiation therapy treatment plans in a comprehensive and user-friendly Monte Carlo (MC) framework.
The aim of this study was to build a simulation framework evaluate the number DNA double-strand breaks (DSBs) induced by in vitro targeted radionuclide therapy (TRT). This work represents first step toward exploring underlying biologic mechanisms and influence physical chemical parameters enable better response prediction patients. We used tool characterize early DSB induction 177Lu-DOTATATE, commonly TRT for neuroendocrine tumors. Methods: A multiscale approach implemented simulate DSBs...
Percutaneous coronary interventions (PCI) of chronic total occlusions (CTO) increase the risk high radiation exposure for both patient and cardiologist. This study evaluated maximum dose to patients' skin (MSD) cardiologists during CTO-PCI. Moreover, efficiency radioprotective drapes reduce cardiologist was assessed. Patient measured 31 procedures; cardiologist's extremities were 65 procedures, among which performed with drapes. The MSD (median: 1254 mGy; max: 6528 mGy), higher than 2 Gy 33%...
ABSTRACT Background Immune checkpoint inhibitors (ICI) are routinely used in advanced clear cell renal carcinoma (ccRCC). However, a substantial group of patients does not respond to ICI therapy. Radiation is promising approach increase response rates since it can generate anti-tumor immunity. Targeted radionuclide therapy (TRT) systemic radiation treatment, ideally suited for precision irradiation metastasized cancer. Therefore, the aim this study explore potential combined TRT, targeting...
To model dose-response relationships for in vivo experiments with radiolabelled peptides enabling maximum therapeutic efficacy while limiting toxicity to kidney and bone marrow.A multiregional murine phantom, a kinetic cortex outer medulla distribution, were used predict renal toxicity. Maximum tolerated activities avoid nephrotoxicity (at 40 Gy Biological Effective Dose BED) hematologic 2 Gy) compared. The of 90Y, 161Tb, 177Lu 213Bi was assessed at their respective based on cellular-level...