A5014166349- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Breast Cancer Treatment Studies
- Radioactivity and Radon Measurements
- Graphite, nuclear technology, radiation studies
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Digital Radiography and Breast Imaging
- Cerebral Palsy and Movement Disorders
- Effects of Radiation Exposure
- Anatomy and Medical Technology
- Radiomics and Machine Learning in Medical Imaging
- Vascular Tumors and Angiosarcomas
- Lung Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Neuroblastoma Research and Treatments
- Radiation Shielding Materials Analysis
- Ear and Head Tumors
National Cancer Institute
2016-2024
National Institutes of Health
2016-2024
Division of Cancer Epidemiology and Genetics
2020-2023
Government of the United States of America
2022
National Institute of Standards and Technology
2008-2015
Rensselaer Polytechnic Institute
2008-2013
Physical Measurement Laboratory
2013
University of Maryland, College Park
2008
Northwestern University
2004-2005
Although it is known that obesity has a profound effect on x-ray computed tomography (CT) image quality and patient organ dose, quantitative data describing this relationship are not currently available. This study examines the of calculated radiation dose to organs tissues from CT using newly developed phantoms representing overweight obese patients. These were derived previously RPI-adult male female computational phantoms. The result was set ten (five males, five females) with body mass...
The physical properties of protons lower doses to surrounding normal tissues compared with photons, potentially reducing acute and long-term adverse effects, including subsequent cancers. magnitude benefit is uncertain, however, currently based largely on modeling studies. Despite the paucity directly comparative data, number proton centers patients are expanding exponentially. Direct studies potential risks benefits needed in children, who have highest risk radiation-related Pediatric...
We developed an automatic method to segment cardiac substructures given a radiotherapy planning CT images support epidemiological studies or clinical trials looking at disease endpoints after radiotherapy.We used most-similar atlas selection algorithm and 3D deformation combined with 30 detailed atlases. cross-validated our within the library by evaluating geometric comparison metrics comparing doses for simulated breast between manual contours. analyzed impact of number in use guide points...
Abstract Purpose To demonstrate an on‐demand and nearly automatic method for fabricating tissue‐equivalent physical anthropomorphic phantoms imaging dosimetry applications using a dual nozzle thermoplastic three‐dimensional (3D) printer two types of plastic. Methods Two 3D printing plastics were investigated: (a) Normal polylactic acid (PLA) as soft tissue simulant (b) Iron PLA (PLA‐Fe), composite iron powder, bone simulant. The geometry 1‐yr‐old computational phantom combined with extrusion...
Background and purposeContouring of organs at risk is important for studying health effects following breast radiotherapy. However, manual contouring time-consuming subject to variability. The purpose this study was develop a deep learning-based method automatically segment multiple structures on radiotherapy planning computed tomography (CT) images.Materials methodsWe used data from 118 patients, including 90 diagnostic CT scans with expert structure delineations training 28 images testing....
Purpose: Accelerated partial breast irradiation via interstitial balloon brachytherapy is a fast and effective treatment method for certain early stage cancers. The radiation can be delivered using conventional high‐dose rate (HDR) gamma‐emitting source or novel electronic (eBx) which uses lower energy x rays that do not penetrate as far within the patient. A previous study [A. Dickler, M. C. Kirk, N. Seif, K. Griem, Dowlatshahi, D. Francescatti, R. A. Abrams, “A dosimetric comparison of...
Radiation dosimetry is an essential input for epidemiological studies of radiotherapy patients aimed at quantifying the dose-response relationship late-term morbidity and mortality. Individualised organ dose must be estimated all tissues interest located in-field, near-field, or out-of-field. Whereas conventional measurement approaches are limited to points in water anthropomorphic phantoms, computational using patient images human phantoms offer greater flexibility can provide more detailed...
Quantifying radiation dose to cardiac substructures is important for research on the etiology and prevention of complications following radiotherapy; however, segmentation challenging. In this study we demonstrate application our atlas-based automatic method breast cancer radiotherapy plans generating doses in support late effects research.We applied contour heart computed tomography (CT) images 70 patients who received external photon radiotherapy. Two cardiologists provided manual whole...
In vivo radiobioassay is integral to many health physics and radiological protection programs dealing with internal exposures. The Bottle Manikin Absorber (BOMAB) physical phantom has been widely used for whole-body counting calibrations. However, the shape of BOMAB phantoms-a collection plastic, cylindrical shells which contain no bones or organs-does not represent realistic human anatomy. Furthermore, workers who come in contact radioactive materials have rather different body size. To...
Radiotherapy (RT) treatment planning systems (TPS) are designed for the fast calculation of dose to tumor bed and nearby organs at risk using x-ray computed tomography (CT) images. However, CT images a patient typically available only small portion body, in some cases, such as retrospective epidemiological studies, no may be all. When that lie out-of-scan must estimated, convenient alternative unknown anatomy is use matching whole-body computational phantom surrogate. The purpose current...
Epidemiological investigation is an important approach to assessing the risk of late effects after radiotherapy, and organ dosimetry a crucial part such analysis. Computed tomography (CT) images, if available, can be valuable resource for individualizing dosimetry, because they describe specific anatomy patient. However, CT images acquired radiation treatment planning purposes cover only portion body near target volume, whereas epidemiology, interest lies in more distant normal tissues,...
Significant efforts such as the Pediatric Proton/Photon Consortium Registry (PPCR) involving multiple proton therapy centers have been made to conduct collaborative studies evaluating outcomes following therapy. As a groundwork dosimetry effort for late effect investigation, we developed Monte Carlo (MC) model of pencil beam scanning (PBS) estimate organ/tissue doses pediatric patients at Maryland Proton Treatment Center (MPTC), one involved in PPCR. The MC modeling was performed using TOPAS...
Objective. We conducted a Monte Carlo study to comprehensively investigate the fetal dose resulting from proton pencil beam scanning (PBS) craniospinal irradiation (CSI) during pregnancy.Approach. The gestational-age dependent pregnant phantom series developed at University of Florida (UF) were converted into DICOM-RT format (CT images and structures) imported treatment planning system (TPS) (Eclipse v15.6) commissioned IBA PBS nozzle. A CSI plan (prescribed dose: 36 Gy) was created on...
. To allow the estimation of secondary cancer risks from radiation therapy treatment plans in a comprehensive and user-friendly Monte Carlo (MC) framework.
This pilot study was done to determine the feasibility and accuracy of University Florida/National Cancer Institute (UF/NCI) phantoms Monte Carlo (MC) retrospective dosimetry had two aims: (1) anatomic UF/NCI by comparing 3D organ doses in National Wilms Tumor Study (NWTS) patient-matched corresponding CT scans (2) compare infield out-of-field using methods-standard radiation therapy (RT) treatment planning systems (TPS) MC these models.Twenty NWTS Digital Imaging Communications Medicine...
The International Atomic Energy Agency (IAEA) has organized an international comparison to assess Single Photon Emission Computed Tomography (SPECT) image quantification capabilities in 12 countries.Iodine-131 was chosen as the radionuclide for because of its wide use around world, but logistical reasons solid 133 Ba sources were used a long-lived surrogate 131 I.For this study, we designed set cylindrical so that each site could have phantoms (having nominal volumes 2 mL, 4 6 and 23 mL)...
To study the accuracy with which proton stopping power ratio (SPR) can be determined dual-energy computed tomography (DECT) for small structures and bone-tissue-air interfaces like those found in head or neck.Hollow cylindrical polylactic acid (PLA) plugs (3 cm diameter, 5 height) were 3D printed containing either one three septa thicknesses tsepta = 0.8, 1.6, 3.2, 6.4 mm running along length of plug. The cylinders inserted individually into a tissue-equivalent phantom (16 height). First,...
The risks associated with exposure to external fields of ionising radiation are important quantify in order provide guidance towards public and worker protection. In Publication 116 2010, the International Commission on Radiological Protection (ICRP) published adult male female fluence-to-dose coefficients (henceforth referred as dose coefficients) for exposures six types idealised neutron fields. However, ICRP not appropriate applications involving children due their smaller body weight...
Monte Carlo (MC) radiation transport methods are used for dose calculation as 'gold standard.' However, the method is computationally time-consuming and thus impractical normal tissue reconstructions large number of proton therapy patients required epidemiologic investigations late health effects. In present study, we developed a new rapid reconstruction out-of-field neutron to undergoing pencil beam scanning (PBS) therapy. The based on voxel kernels (DVKs) generated by MC simulations...
For the epidemiological evaluation of long-term side effects radiotherapy patients, it is important to know doses organs and tissues everywhere in patient. Computed tomography (CT) images patients which contain anatomical information are sometimes available for each treated However, CT scans usually cover only volume patient including target surrounding anatomy. To overcome this limitation, work we describe development a software tool using Varian Eclipse Scripting API extending partial-body...
PurposeOur purpose was to validate and compare the performance of 4 organ dose reconstruction approaches for historical radiation treatment planning based on 2-dimensional radiographs.Methods MaterialsWe considered 10 patients with Wilms tumor computed tomography images whom we developed typical historic plans, using anteroposterior posteroanterior parallel-opposed 6 MV flank fields, normalized 14.4 Gy. Two plans were created each patient, without corner blocking. Regions interest (lungs,...