A5048228302- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Pediatric Urology and Nephrology Studies
- Sexual Differentiation and Disorders
- Aldose Reductase and Taurine
- Pelvic floor disorders treatments
- Testicular diseases and treatments
- Sperm and Testicular Function
- Tissue Engineering and Regenerative Medicine
- Bladder and Urothelial Cancer Treatments
- Ureteral procedures and complications
- Urologic and reproductive health conditions
- Genital Health and Disease
- Hernia repair and management
- Urinary Tract Infections Management
- Renal and related cancers
- Muscle metabolism and nutrition
- Hormonal and reproductive studies
- Kidney Stones and Urolithiasis Treatments
- Urinary and Genital Oncology Studies
- Circadian rhythm and melatonin
- Caveolin-1 and cellular processes
- Hormonal Regulation and Hypertension
- Male Reproductive Health Studies
- Signaling Pathways in Disease
Children's Hospital of Philadelphia
2016-2025
Hospital of the University of Pennsylvania
1988-2025
University of Pennsylvania
2013-2024
Philadelphia University
1995-2017
Thomas Jefferson University
2016
Sidney Kimmel Cancer Center
2016
Naval Medical Center San Diego
2013
Children's National
2011
George Washington University
2011
Scripps Research Institute
2008
Results following distal hypospadias repair are favorable. Grouping proximal and artificially increases the perceived success rate of hypospadias. We identified our complication hypothesized a higher for 1-stage repair.We retrospectively reviewed records consecutive boys who underwent from 2007 to 2014. Proximal was defined as urethral meatus location at or more than penoscrotal junction after penile degloving. further stratified into those with planned vs 2-stage repair. Univariate Cox...
No AccessJournal of UrologyPediatric Urology1 Apr 1998SURGICAL MANAGEMENT OF THE NONPALPABLE TESTIS: CHILDREN'S HOSPITAL PHILADELPHIA EXPERIENCE ANDREW J. KIRSCH, JOSE ESCALA, JOHN W. DUCKETT, GRAHAME H.H. SMITH, STEPHEN A. ZDERIC, DOUGLAS CANNING, and HOWARD M. SNYDER KIRSCHANDREW KIRSCH More articles by this author , ESCALAJOSE ESCALA DUCKETTJOHN DUCKETT (Duckett) Deceased. SMITHGRAHAME SMITH ZDERICSTEPHEN ZDERIC CANNINGDOUGLAS CANNING SNYDERHOWARD View All Author...
Detrusor smooth muscle (DSM) undergoes hypertrophy after partial bladder outlet obstruction (PBOO) in male rabbits, as it does men with PBOO induced by benign prostatic hyperplasia. Despite detrusor hypertrophy, some bladders are severely dysfunctional (decompensated). In this study, the rabbit model for was used to determine biochemical regulation of contractile apparatus and force maintenance from decompensated (DB). Bladders sham-operated rabbits served a control. On stimulation 125 mM...
A high rate of spontaneous resolution or decrease in urinary tract dilatation is expected for most cases primary megaureter (PM). We analyzed our results with extended long-term nonsurgical treatment a group children diagnosed prenatally detected PM. also sought to determine the safety this approach and clinical significance residual hydroureteronephrosis (HUN) when complete does not occur.We reviewed experience 40 infants hydronephrosis as PM who were initially treated nonoperatively...
Testicular teratoma is a rare neoplasm affecting the pediatric population and has classically been reported to be second most common testis tumor in children behind yolk sac tumors. teratomas are benign partial orchiectomy may considered. We describe our single institution experience with testicular definitive treatment preserving surgery.We reviewed pathology records at for all paratesticular tumors diagnosed between 1976 November 2002 males younger than 18 years. specifically examined...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChiral trialkylborane reducing agents. Preparation of 1-deuterio primary alcohols high enantiomeric purityM. Mark Midland, Sue Greer, Alfonso Tramontano, and Stephen A. ZdericCite this: J. Am. Chem. Soc. 1979, 101, 9, 2352–2355Publication Date (Print):April 1, 1979Publication History Published online1 May 2002Published inissue 1 April 1979https://pubs.acs.org/doi/10.1021/ja00503a019https://doi.org/10.1021/ja00503a019research-articleACS...
We investigated longer term urological outcomes in patients enrolled the Management of Myelomeningocele Study (MOMS).Women who participated original trial were asked for consent followup their child at age 6 years or older a single comprehensive study visit to MOMS center. Participating children underwent and radiologic procedures provide objective evidence current bladder functioning. Primary outcome was defined as any among need clean intermittent catheterization, vesicostomy, urethral...
Several studies have anecdotally reported the occurrence of altered urinary voiding patterns in rodents exposed to social stress. A recent study characterized urodynamic and central changes a rat model defeat. Here, we describe similar phenotype induced mice by stress addition potential molecular mechanisms underlying resulting bladder wall remodeling. The mechanism leading habits may be relevant human syndrome dysfunctional which is thought psychological component. To better characterize...
Approximately 20% of boys with posterior urethral valves develop ESRD; however, few factors associated the risk ESRD have been identified. The objective this study was to determine if renal parenchymal area, defined as area kidney minus pelvicaliceal system on first postnatal ultrasound, is in infants valves.A retrospective cohort who were diagnosed at less than 6 months age between 1988 and 2011 followed for least 1 year a free-standing children's hospital assembled. Cox proportional hazard...
No AccessJournal of UrologyPEDIATRIC UROLOGY1 Dec 2002The Ascending Testis and the Undescended Since Birth Share Same Histopathology SUSAN L. RUSNACK, HSI-YANG WU, DALE S. HUFF, HOWARD M. SNYDER, STEPHEN A. ZDERIC, MICHAEL C. CARR, DOUGLAS CANNING RUSNACKSUSAN RUSNACK More articles by this author , WUHSI-YANG WU HUFFDALE HUFF SNYDERHOWARD SNYDER ZDERICSTEPHEN ZDERIC CARRMICHAEL CARR CANNINGDOUGLAS View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64223-1AboutFull TextPDF...
Partial urinary bladder outlet obstruction (PBOO) in men, secondary to benign prostatic hyperplasia, induces detrusor smooth muscle (DSM) hypertrophy. However, despite DSM hypertrophy, some bladders become severely dysfunctional (decompensated). Using a rabbit model of PBOO, we found that although from sham-operated expressed nearly 100% both the myosin heavy chain isoform SM-B and essential light LC 17a , as much 75% SM-A 40% 17b (both associated with decreased maximum velocity shortening)....
We evaluated our 8-year experience with buccal mucosal grafts in complex hypospadias and epispadias repair.We reviewed the records of 29 patients whom a total 30 were placed as part urethral reconstruction between 1991 1999. At surgery 16 tubes 14 onlays constructed 24 repairs involved meatus. All followed at least 6 months postoperatively (median 5.3 years). Beginning 1995 meatal design was enlarged to racquet handle shape asked perform self-dilation for postoperatively.Complications...
No AccessJournal of UrologyPediatric Urology1 Nov 2005TESTICULAR MICROLITHIASIS AND ANTISPERM ANTIBODIES FOLLOWING TESTICULAR BIOPSY IN BOYS WITH CRYPTORCHIDISM RAKESH P. PATEL, THOMAS F. KOLON, DALE S. HUFF, MICHAEL C. CARR, STEPHEN A. ZDERIC, DOUGLAS CANNING, and HOWARD M. SNYDER PATELRAKESH PATEL More articles by this author , KOLONTHOMAS KOLON HUFFDALE HUFF CARRMICHAEL CARR ZDERICSTEPHEN ZDERIC CANNINGDOUGLAS CANNING SNYDERHOWARD View All Author...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of optically active benzyl-.alpha.-d alcohol via reduction by B-3.alpha.-pinanyl-9-borabicyclo[3.3.1]nonane. A new highly effective chiral reducing agentM. Mark Midland, Alfonso Tramontano, and Stephen A. ZdericCite this: J. Am. Chem. Soc. 1977, 99, 15, 5211–5213Publication Date (Print):June 1, 1977Publication History Published online1 May 2002Published inissue 1 June...
Large-conductance voltage- and calcium-activated potassium (BK) channels have been shown to play a role in detrusor overactivity (DO). The goal of this study was determine whether bladder outlet obstruction-induced DO is associated with downregulation BK affect myosin light chain 20 (MLC ) phosphorylation smooth muscle (DSM). Partial obstruction (PBOO) surgically induced male New Zealand White rabbits. rabbit PBOO model shows decreased voided volumes increased voiding frequency. DSM from...
The growing field of urinary proteomics shows promise to expand the number biomarkers for diagnosis and prognosis a human diseases. With rapid developments in mass spectrometry methods proteome quantification, there exists an opportunity improved sample processing separation workflows make important contributions urine proteomic analyses. Here we evaluate performance four preparation methods: MStern, PreOmics in-StageTip (iST), suspension-trapping (S-Trap), conventional urea In-Solution...
Widespread utilization of telemedicine in our practice to date has been limited the evaluation certain post-surgical patients. The COVID-19 pandemic acutely stressed established system and required us enhance telemedicine. We hypothesized that expansion new follow up patient visits for pediatric urology could be done effectively a way satisfied parental expectations.Using pre-COVID-19 program based electronic medical record (EMR), patients providers transitioned primarily virtual when...
Urologists rely heavily on videourodynamics to identify patients with neurogenic bladders who are at risk of upper tract injury, but their interpretation has high interobserver variability. Our objective was develop deep learning models studies categorize severity bladder dysfunction.We performed a cross-sectional study aged 2 months 28 years spina bifida underwent single institution between 2019 and 2021. The outcome degree dysfunction, defined as none/mild, moderate, severe, by panel 5...
No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Jun 2002Enhanced Force Generation by Corpus Cavernosum Smooth Muscle in Rabbits With Partial Bladder Outlet Obstruction SHAOHUA CHANG, JOSEPH A. HYPOLITE, STEPHEN ZDERIC, ALAN J. WEIN, SAMUEL CHACKO, and MICHAEL E. DiSANTO CHANGSHAOHUA CHANG , HYPOLITEJOSEPH HYPOLITE ZDERICSTEPHEN ZDERIC WEINALAN WEIN CHACKOSAMUEL CHACKO DiSANTOMICHAEL View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65050-1AboutFull TextPDF ToolsAdd to...
Congenital giant diverticulum of the bladder is a consequence deficiency in detrusor musculature and has been reported male infants as rare cause outlet obstruction.A 10-year retrospective review revealed 4 patients (3 boys 1 girl) with obstruction due to diverticulum. Prenatal postnatal clinical imaging records were reviewed.Prenatal sonography was unremarkable all patients. Three males (ages months, 10 months 3 years) had no medical history voiding dysfunction, female (11 Ehlers-Danlos...