A5056167993- Complement system in diseases
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Ocular Surface and Contact Lens
- Diatoms and Algae Research
- Dermatology and Skin Diseases
- Alzheimer's disease research and treatments
- Ocular Infections and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive System and Pregnancy
- Retinal Diseases and Treatments
- Surfactants and Colloidal Systems
- Retinal Imaging and Analysis
- Corneal Surgery and Treatments
- Paleopathology and ancient diseases
- Apelin-related biomedical research
- Autopsy Techniques and Outcomes
- Wound Healing and Treatments
- Protist diversity and phylogeny
- Dementia and Cognitive Impairment Research
- Neuropeptides and Animal Physiology
- Barrier Structure and Function Studies
- Psoriasis: Treatment and Pathogenesis
Assiut University
2008-2024
Cardiff University
2016-2022
UK Dementia Research Institute
2019-2022
Egyptian Museum
2012
Plasma biomarkers for Alzheimer's disease-related pathologies have undergone rapid developments during the past few years, and there are now well-validated blood tests amyloid tau pathology, as well neurodegeneration astrocytic activation. To define disease with rather than clinical assessment, we assessed prediction of research-diagnosed status using these tested genetic variants associated that may reflect more accurately risk biochemically defined instead dementia. In a cohort cases [n =...
To enhance anthralin efficacy against psoriasis and reduce its notorious side effects, it was loaded into various liposomal ethosomal preparations. The nanocarriers were characterized for drug encapsulation efficiency, size, morphology compatibility between components. Optimum formulations dispersed in gel bases release kinetics studied. Clinical safety of Pluronic®F-127 gels evaluated patients having (clinicaltrials.gov identifier is NCT03348462). Safety assessed by recording adverse...
Abstract Age-related macular degeneration (AMD) is a leading cause of blindness. Genetic variants at the chromosome 1q31.3 encompassing complement factor H ( CFH , FH) and related genes CFHR1-5 ) are major determinants AMD susceptibility, but their molecular consequences remain unclear. Here we demonstrate that FHR-4 plays prominent role in pathogenesis. We show systemic levels elevated P -value = 7.1 × 10 −6 ), whereas no difference seen for FH. Furthermore, accumulates choriocapillaris,...
Article2 June 2020Open Access Transparent process Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway Natacha Ipseiz Systems Immunity Research Institute, Heath Park, Cardiff University, Cardiff, UK Search for more papers by this author Robert J Pickering orcid.org/0000-0003-3332-9868 Marcela Rosas Victoria Tyrrell Luke C Davies Selinda Orr Wellcome-Wolfson Institute Experimental Medicine, School of Dentistry and Biomedical Science, Queen's...
Peripheral immune markers have previously been linked to a poor response antipsychotic medication and more severe negative symptoms at the onset of psychosis. The present study investigated association blood cytokines complement with presence non-response symptom severity in patients psychosis.This cross-sectional recruited 94 schizophrenia other psychoses, whom 47 were defined as responders non-responders. In all subjects we measured plasma levels (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10,...
To study the clinical effect of topical controlled-release ophthalmic fluconazole liposomal formulation and to compare its with solution in a reproducible model Candida keratitis rabbits.Forty adult rabbits were included this study. Right eyes inoculated freshly prepared Caindida albicans strain no. 4925 showed signs infected keratitis. The divided randomly into two groups: first group (18 rabbits) right received solution, while second (22 fluconazole-loaded liposomes. rabbits' examined...
Objective: Glaucoma is a leading cause of irreversible blindness worldwide. Whereas latanoprost one the most effective drugs in glaucoma treatment, its eye drops need frequent application to lack patient adherence. This study aimed develop patient-friendly niosome-in-gel system for sustained ocular delivery latanoprost.Methods: Niosomes were prepared by reverse-phase evaporation technique and optimized different formulation parameters, such as cholesterol/surfactant drug/surfactant ratios....
Current development of drug microcarriers is mainly based on spherical shapes, which are not biologically favorable geometries for complex interactions with biological systems. Scalable synthesis carriers nonspherical and anisotropic shapes featuring sustained drug‐releasing performances, biocompatibility, degradability, sensing capabilities challenging. These challenges addressed in this work by employing Nature's optimized designs obtained from low‐cost diatomaceous earth mineral derived...
Non-ionic surfactant vesicles were prepared using Span-60 and cholesterol in the mass ratios of 1:1, 2:1, 1:2 3:1 for transdermal delivery an anti-inflammatory drug meloxicam (MXM). The encapsulation efficiencies particle size observed range 32.9-80.7% 56.5-133.4 nm, respectively. Three different gel bases also Poloxamer-407, Chitosan Carbopol-934 as polymers to study performance vitro release drug. Prepared gels converted into niosomal gels. In characteristics MXM from carried out dialysis...
Drug delivery using synthetic nanoparticles including porous silicon has been extensively used to overcome the limitations of chemotherapy. However, their synthesis many challenges such as lack scalability, high cost, and use toxic materials with concerning environmental impact. Nanoscale obtained from natural resources are an attractive option address some these disadvantages. In this paper, a new mesoporous biodegradable nanoparticle (SiNP) drug carrier diatom silica mineral available...
Background: Niosomes are non-ionic stable vesicular system, which can accommodate both hydrophobic and hydrophilic drugs. The aim of the present study was to prepare characterize niosomal gel formulations for sustained delivery aceclofenac. Aceclofenac is most widely used anti-inflammatory agent in treatment rheumatoid arthritis. It has narrow therapeutic index short biological half-life.
Background: Multiple sclerosis (MS) can be difficult to differentiate from other demyelinating diseases, notably neuromyelitis optica spectrum disorder (NMOSD). We previously showed that NMOSD is distinguished MS by plasma complement biomarkers. Objective: Here, we measure cerebrospinal fluid (CSF) proteins in MS, and clinically isolated syndrome (CIS), a neurological episode may presage test whether these distinguish CIS. Materials methods: CSF (53 17 CIS, 11 NMOSD, 35 controls) was...
<b>Objective</b> To investigate the true character of harem conspiracy described in Judicial Papyrus Turin and determine whether Ramesses III was indeed killed. <b>Design</b> Anthropological, forensic, radiological, genetic study mummies unknown man E, found together taken from 20th dynasty ancient Egypt (circa 1190-1070 BC). <b>Results</b> Computed tomography scans revealed a deep cut III's throat, probably made by sharp knife. During mummification process, Horus eye amulet inserted wound...
Abstract Preclinical Research The objective of this work was to evaluate liposome‐containing gel formulations for the sustained, site‐specific delivery celecoxib ( CXB ). Liposomes composed phosphadtidylcholine (and various amounts cholesterol C h) were prepared using thin film hydration and characterized encapsulation efficiency, vesicle size, drug‐excipient interaction differential scanning calorimetry F ourier‐transform infrared spectroscopy. selected liposome formulation incorporated in...
Purpose: To study the clinical effect of a topical controlled-release ophthalmic fluconazole liposomal formulation on patients with Candida keratitis. Methods: Eleven eyes 11 albicans corneal fungal infection (proved by cultures) were included in this study. All treated (2 mg/mL) 3 times daily. The response to treatment was divided into categories: complete improvement, healing scar formation at end 1 month; partial decrease ulcer size and no includes extension and/or perforation that...
Recent studies have identified roles for complement in synaptic pruning, both physiological during development and pathological Alzheimer's disease (AD). These reports suggest that C1q initiates activation on synapses C3 fragments then tag them removal by microglia. There is an urgent need to characterise these processes rodent AD models; this requires the of reagents methods detection quantification fluids tissues. will enable better evaluation role its value as biomarker. We describe...
Abstract Background The complement cascade is increasingly implicated in development of a variety diseases with strong immune contributions such as Alzheimer’s disease and Systemic Lupus Erythematosus. Mouse models have been used to determine function central components the C1q C3. However, species differences their gene structures mean that mice do not adequately replicate human regulators, including CR1 CR2 . Genetic variation modifying states but mechanisms are known. Results To decipher...
A. Santos, D. Losic, and co-workers demonstrate on page 5107 the preparation of luminescent silicon diatom replicas with unique porous microcapsule structures, by conversion from silica diatoms using a reduction process. These are biodegradable have intrinsic luminescence, sensing drug-releasing properties which make them outstanding candidates for low-cost micro-carriers drug delivery, theranostics, guided micro-robotic devices.