A5067250422- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
- HIV Research and Treatment
- Probiotics and Fermented Foods
- Steroid Chemistry and Biochemistry
- Herbal Medicine Research Studies
- Clostridium difficile and Clostridium perfringens research
- Pharmacological Effects and Toxicity Studies
- Toxin Mechanisms and Immunotoxins
- Pediatric health and respiratory diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Ginseng Biological Effects and Applications
- HIV-related health complications and treatments
Délégation Paris 5
2019
Université Paris Cité
2019
Conservatoire National des Arts et Métiers
2010-2018
Both mucus and mucosa-associated bacteria form a specific environment in the gut; their disruption may play crucial role development of intestinal bowel disease (IBD). Metronidazole, an antibiotic used treatment IBD, alters gut microbiota reduces basal oxidative stress to proteins colonic tissue healthy rats. The aim this study was evaluate impact altered due metronidazole on thickness layer. This performed untreated rats (control group) or treated by (metronidazole-treated rats, 1 mg mL(-1)...
This study aimed at evaluating the alteration of colonic microbiota and changes in mucus layer thickness induced by oral administration living bifidobacteria rats. The was performed on rats fed with Bifidobacterium pseudolongum strain Patronus (1010 bacteria per day for 7 days). bacterial led to a large increase (57%, P < 0.05). Both quantitative PCR high-throughput sequencing 16S rRNA gene revealed significant amount genus Patronus, associated decrease Akkermansia muciniphila. could be due...
Metronidazole (MTZ) and Cotrimoxazole (CTX) are used in HIV/AIDS patients eligible for antiretroviral treatment. The objective of this animal study was to determine whether pre-treatment with antibiotics affects the intestinal bioavailability Atazanavir (ATV) Ritonavir (RTV). After oral administration 1 mg MTZ CTX 7 days, rat colonic mucosa were analyzed mucus thickness or placed Ussing chambers measure ATV RTV net transepithelial fluxes (Jnet). 1. In control rats, 43.3±7.6 µm 40.7±6.9 µm,...
Cotrimoxazole (TMP-SMX) is concomitantly used as a primary prophylaxis of opportunistic infections with antiretroviral agents, such Atazanavir (ATV). Results from an ex vivo study showed changes in intestinal absorption ATV when rats were pretreated TMP-SMX. The objective this to determine the effect TMP-SMX on pharmacokinetics rats. We also studied gut microbiota induced by non-compartment analysis compare parallel group treated low or therapeutic dose for nine days untreated control Gut...