A5028104605- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Autoimmune and Inflammatory Disorders
- Lymphoma Diagnosis and Treatment
- Nail Diseases and Treatments
- Cancer and Skin Lesions
- Systemic Sclerosis and Related Diseases
- Drug-Induced Adverse Reactions
- Vascular Tumors and Angiosarcomas
- Eosinophilic Disorders and Syndromes
- Hidradenitis Suppurativa and Treatments
- Oral Health Pathology and Treatment
- Contact Dermatitis and Allergies
- Platelet Disorders and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Genital Health and Disease
- Immune cells in cancer
- Urticaria and Related Conditions
- Cholesterol and Lipid Metabolism
- Dermatologic Treatments and Research
- Nonmelanoma Skin Cancer Studies
- Fungal Infections and Studies
- Steroid Chemistry and Biochemistry
Kagoshima University
2016-2025
Yokohama Municipal Citizen's Hospital
2022-2025
Tokyo Metropolitan University
2023-2025
Osaka Metropolitan University
2023-2025
Kagoshima City Hospital
2025
Otsu Municipal Hospital
2024
JR Tokyo General Hospital
2023
Kyushu University
2008-2022
International University of Kagoshima
2017
National Institutes of Health
2003-2012
Abstract Introduction The systemic immune-inflammation index (SII) has emerged as a promising prognostic marker in various malignancies. However, its significance patients with small-cell lung cancer (SCLC) treated immune checkpoint inhibitors (ICIs) remains unclear. In this study, we evaluated the impact of SII SCLC after ICI use. Methods Of 62 who received chemoimmunotherapy at our institution between September 2019 and July 2024, retrospectively analyzed 36 subsequently maintenance...
Cyclooxygenase (COX)-2 is one of the rate-limiting enzymes in conversion arachidonic acid to prostaglandins and other eicosanoids. Recent studies have shown enhanced expression COX-2 cancer cells several tissues. We investigated prostaglandin (PG) E((2)) production two human skin epidermal cell lines: cutaneous squamous carcinoma, HSC-5, eccrine EcCa. Both PGE((2)) were significantly lines compared with non-tumorigenic keratinocyte line, HaCaT. In order determine role proliferation HSC-5...
Abstract Previous studies on family history of psoriasis showed that patients with a have an earlier onset the disease, but such in Japan are still limited. To elucidate characteristics familial psoriasis, we studied using West Psoriasis Registry, multi‐institutional registry operated by 26 facilities western part Japan, including university hospitals, community and clinics. This study enrolled 1847 registered between September 2019 December 2021, 199 (10.8%) having psoriasis. Patients had...
Abstract Generalized pustular psoriasis (GPP) is a rare and severe subtype of psoriasis. Because its rarity, GPP studies with large sample size have been scarce. We studied the characteristics using data from West Japan Psoriasis Registry that had registered until end December 2020. The dataset included 104 patients 1290 other subtypes Multivariate analysis revealed significantly greater number female patients, lower mean body mass index, ratio habitual drinkers in psoriasis, compared to Of...
Abstract Systemic treatments are important for patients with moderate‐to‐severe psoriasis; however, they may occasionally cause adverse infectious events. Although the risk of severe infections psoriatic is well established, little known about cutaneous infections. Therefore, we studied frequency in psoriasis who underwent biologic treatment. A total 878 (237 females and 641 males) were analyzed this follow‐up survey conducted 2020 based on Western Japan Psoriasis Registry. The observed skin...
Psoriasis affects approximately 0.3% of the Japanese population. Recently, various effective systemic drugs have become available, and continuation a given treatment has critical because chronic nature psoriasis. Factors affecting drug survival (the time until discontinuation) in psoriasis include efficacy, safety, ease use, patient preference. In present study, authors retrospectively surveyed multifacility registry to determine real-world evidence rate interventions for treatment. Patients...
Kurozu (Japanese black vinegar), a traditional product made from unpolished rice, contains beneficial organic materials and minerals. Improved manufacturing processes yielded new vinegar, Izumi, that large amounts of these constituents. Because the antioxidative effects are well understood, we examined Izumi for its anticancer activity against human squamous cell carcinoma (SCC) line HSC-5. HSC-5 cells were treated with or ordinary grain vinegar adjusted to 4.2% acidicity. MTT assay trypan...
Abstract Background Traditionally, dermatophytosis, a common disease affecting millions of people world‐wide, has been diagnosed by direct microscopy and fungal culture. The immunochromatography (ICG) strip test was recently developed. Methods We compared the performance ICG for detection dermatophytes in samples from human skin nails with microscopy. 160 samples, consisting 88 72 nail specimens, were subjected to study using 20% KOH solution examination test. Of 18 examined culture...
Abstract Psoriasis, a chronic inflammatory skin disease, is closely related to systemic metabolism. An elevated body mass index ( BMI ) risk factor for psoriasis; inflammasomes are activated by adipose tissue macrophages in obese subjects. We hypothesized that hyperlipidaemia involved the pathogenesis of psoriasis and examined role high‐fat diet HFD development imiquimod IMQ )‐treated mice. The weight serum level cholesterol were significantly higher mice fed an than regular RD ). had...
Abstract Granulocyte and monocyte adsorptive apheresis (GMA) selectively removes activated granulocytes monocytes from the peripheral blood. In 2012, GMA was approved in Japan as a treatment for generalized pustular psoriasis localized or palmoplantar pustulosis (PPP). Limited evidence case reports monocentric studies suggested that is an effective skin joint symptoms of PPP with pustulotic arthro‐osteitis (PAO). The present, prospective, observational study performed at three dermatology...
Between January 2022 and December 2023, the Toshiwakai long-term care facility (LTCF) experienced a COVID-19 cluster. Among 231 infected residents, 253 episodes were identified, including 20 residents who reinfected once one was twice. The strict infection control operation antiviral treatments promptly administered; however, four died, five hospitalized within 10 days (two due to fractures). Most symptomatic cases resolved days. A comparison of mortality rates between uninfected showed no...
Background: Long-term care facilities (LTCFs) remain highly vulnerable to COVID-19. Despite reduced virulence, Omicron’s high transmissibility poses ongoing risks. The effect of infection under strict control measures and early antiviral treatment remains unclear. Methods: We conducted a retrospective cohort study in 450-bed LTCF, which implemented rigorous use, evaluating survival outcomes during repeated Omicron outbreaks from January 2022 December 2023 using Cox regression with...
ABSTRACT Introduction Activated neutrophils play a crucial role in the development of neutrophilic dermatoses, including pustular psoriasis. Adsorptive granulocyte and monocyte apheresis (GMA) is an effective treatment for skin disorders. Although previous basic research has demonstrated neutrophil activation, no efficient method exists to assess it clinical settings. Methods We measured activity patients with GPP who underwent GMA therapy using FLP‐H4200, newly developed evaluation system....
Th17 cells play an important role in psoriasis. The differentiation of naïve CD4+ T into depends on glycolysis as the energy source. CD147/basigin, integral transmembrane protein belonging to immunoglobulin superfamily, regulates association with monocarboxylate transporters (MCTs)-1 and -4 cancer cells. We examined whether CD147/basigin is involved pathogenesis psoriasis humans psoriasis-model mice. serum level CD147 was increased patients psoriasis, expression MCT-1 elevated their dermal...
The use of random skin biopsy (RSB) to diagnose intravascular large B cell lymphoma (IVLBCL) has increased.To explore the indication for RSB IVLBCL.We retrospectively evaluated medical records 18 Japanese adults who underwent between January 2008 and December 2009.A final diagnosis IVLBCL was returned in 2 patients based on findings 1 brain findings. All 3 manifested neurological symptoms, hematocytopenia, elevated levels LDH soluble interleukin-2 receptor (sIL-2R), absence lymphadenopathy....
Bidens pilosa (BP) Linn. var. radiata is a plant used in traditional folk medicine. It clinically effective various diseases; the pathogenesis of most these involves cyclooxygenase (COX)-2. To investigate mechanism on which clinical effectiveness BP based, we examined its effects COX-2 expression and major product, prostaglandin (PG)E(2), under conditions inflammation. We induced inflammation normal human dermal fibroblasts with interleukin (IL)-1beta PGE(2) production using Western blotting...
CD147/basigin, highly expressed on the surface of malignant tumor cells including melanoma (MM) cells, plays a critical role in invasiveness and metastasis MM. Metastasis is an orchestrated process comprised multiple steps adhesion invasion. Integrin, major molecule, co-localizes with CD147/basigin cell surface. Using human MM line A375 that expresses we investigated whether involved association integrin. was knocked-down using siRNA targeting CD147 to elucidate CD147/basigin. Cell evaluated...
The Raf-MEK-ERK signaling pathway is important during oncogenesis. An activating mutation of BRAF constitutively activates the cascade, and has been identified in ~70% malignant melanomas (MMs). Cluster differentiation 147 (CD147)/basigin an integral plasma membrane protein belonging to immunoglobulin superfamily. highly expressed on MM cells, promotes cellular proliferation tumor growth. present study investigated correlation between CD147 expression using A375 human cell line, which...
Abstract Background Cold agglutination syndrome is a subtype of autoimmune hemolytic anemia. The condition referred to as “cold” because the antibodies become active and induce hemolysis at cold temperatures, typically 3–4 °C, which not always case in other kinds Whereas primary may occur absence underlying conditions, secondary associated with presence infections, including coronavirus disease 2019. Case presentation We report 69-year-old Japanese woman periodontitis who was our hospital...