A5037804730- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Cutaneous lymphoproliferative disorders research
- Psoriasis: Treatment and Pathogenesis
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Skin and Cellular Biology Research
- Viral-associated cancers and disorders
- Immunotherapy and Immune Responses
- Nail Diseases and Treatments
- Asthma and respiratory diseases
- Lymphoma Diagnosis and Treatment
- Contact Dermatitis and Allergies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Cell Function and Interaction
- Fungal Infections and Studies
- Allergic Rhinitis and Sensitization
- Drug-Induced Adverse Reactions
- Vascular Tumors and Angiosarcomas
- CAR-T cell therapy research
- Autoimmune and Inflammatory Disorders
- Eosinophilic Disorders and Syndromes
- Food Allergy and Anaphylaxis Research
- Cancer and Skin Lesions
Okayama University
2016-2025
Okayama University Hospital
2019-2024
Kawasaki Medical School
2012
Shimane University
2012
VA San Diego Healthcare System
2008-2011
University of California, San Diego
2009-2011
UC San Diego Health System
2010
<h3>Objectives</h3> To determine the pathogenic association of latent Epstein-Barr virus (EBV) infections with both typical hydroa vacciniforme (HV) and severe HV-like eruptions, to survey complications outcomes patients. <h3>Design</h3> Case series. <h3>Patients</h3> Twenty-nine patients HV or eruptions. <h3>Interventions</h3> In situ hybridization immunostaining biopsy specimens; extraction DNA samples from cutaneous lesions and/or peripheral blood mononuclear cells for EBV assay. <h3>Main...
Abstract Cathelicidin is strongly expressed in lesional skin psoriasis and may play an important role as both antimicrobial peptide autoinflammatory mediator this chronic disease. The mechanism of increased cathelicidin psoriatic keratinocytes not known, but recent observations have found that has abundant Th17 cells produce IL-17A IL-22. We human stimulated with supernatants from T isolated expression when the presence 1,25-dihydroxyvitamin D3 (1,25D3). This increase was signaled through...
Background. Panton-Valentine leukocidin (PVL) is mainly associated with necrotic suppurative lesions, such as furuncles and abscesses in the skin subcutaneous tissue, but it has also been isolated from patients community-acquired, severe, necrotizing pneumonia. However, clinical manifestations of caused by PVL-producing Staphylococcus aureus role patients' background are not fully understood. Methods. We used polymerase chain reaction amplification to test for PVL gene 161 strains S....
Patients with psoriasis are frequently complicated metabolic syndrome; however, it is not fully understood how obesity and dyslipidemia contribute to the pathogenesis of psoriasis. To investigate mechanisms by which exacerbate using murine models neonatal human epidermal keratinocytes (NHEKs), we used wild-type Apoe-deficient dyslipidemic mice, administered a high-fat diet for 10 weeks induce obesity. Imiquimod was applied ear 5 days psoriatic dermatitis. examine innate immune responses...
Tumor surveillance requires the interaction of multiple molecules and cells that participate in innate adaptive immunity. Cathelicidin was initially identified as an antimicrobial peptide, although it is now clear fulfills a variety immune functions beyond microbial killing. Recent data have suggested contrasting roles for cathelicidin tumor development. Because its role not well understood, we investigated requirement controlling transplantable tumors mice. observed to be abundant...
Journal Article Survival rates and prognostic factors of Epstein–Barr virus‐associated hydroa vacciniforme hypersensitivity to mosquito bites Get access T. Miyake, Miyake Department Dermatology Okayama University Graduate School Medicine, Dentistry Pharmaceutical Sciences 2‐5‐1 Shikata‐cho Kita‐ku 700‐8558 Japan Search for other works by this author on: Oxford Academic Google Scholar Yamamoto, Yamamoto JapanDepartment Kawasaki Medical Y. Hirai, Hirai M. Otsuka, Otsuka Hamada, Hamada K....
Background Cathelicidin antimicrobial peptide LL-37 has the capacity to kill a wide range of microbes and modify host immunity. Recently, our group observed that activation keratinocytes by DNA greatly increases interferon (IFN)-β through Toll-like receptor (TLR)9. However, effect on induction IFN-β TLR3, sensor double-stranded (ds) RNA, in is not well known. Objectives To investigate whether could affect TLR3 signalling antiviral activity normal human epidermal (NHEKs). Methods We...
Abstract Previous studies on family history of psoriasis showed that patients with a have an earlier onset the disease, but such in Japan are still limited. To elucidate characteristics familial psoriasis, we studied using West Psoriasis Registry, multi‐institutional registry operated by 26 facilities western part Japan, including university hospitals, community and clinics. This study enrolled 1847 registered between September 2019 December 2021, 199 (10.8%) having psoriasis. Patients had...
Antidesmoglein (anti-Dsg) 3 serum antibody titres are usually correlated with the disease activity of pemphigus vulgaris (PV), but some patients retain high even in remission.The aim our study was to determine whether anti-Dsg3 antibodies PV sera recognized calcium (Ca(2+) )-dependent or non-Ca(2+) -dependent epitopes, and evaluate their pathogenicity.Dsg3 baculoprotein-coated enzyme-linked immunosorbent assay (ELISA) plates were treated 0.5 mmol L(-1) ethylenediaminetetraacetic acid (EDTA)....
Abstract The effect of persistent skin inflammation on extracutaneous organs and blood is not well studied. Patients with recessive dystrophic epidermolysis bullosa (RDEB), a severe form the inherited blistering disorder, have widespread ulcers, they develop various complications including anaemia, hyperglobulinaemia, hypoalbuminaemia secondary amyloidosis. These are associated bioactivities IL‐6, development amyloidosis requires elevation serum amyloid A (SAA) level. We found that patients...