A5045645419- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health and Psychiatry
- Pharmacological Effects and Toxicity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Psychosomatic Disorders and Their Treatments
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Psychiatric care and mental health services
- Adenosine and Purinergic Signaling
- Electrolyte and hormonal disorders
- Healthcare Decision-Making and Restraints
- Suicide and Self-Harm Studies
- Receptor Mechanisms and Signaling
- Mental Health Treatment and Access
- Parkinson's Disease Mechanisms and Treatments
- Attention Deficit Hyperactivity Disorder
- Transcranial Magnetic Stimulation Studies
Klinik Hietzing
2019-2025
University of Münster
1999-2025
Medical University of Vienna
2008-2025
Otto Wagner Hospital
2011-2024
Wiener Krankenanstaltenverbund
2022
University Hospital Münster
2002-2021
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2021
Austrian Competence Centre of Food Safety
2021
Ludwig-Maximilians-Universität München
1988-2009
Centro de Investigación Biomédica en Red de Salud Mental
2009
Background. The dorsolateral prefrontal cortex (DLPFC) is involved in the pathophysiology of major depression. In particular, metabolic (functional hypometabolism) and structural alterations have been described. this study changes within DLPFC severely depressed patients before after electroconvulsive therapy (ECT) were evaluated by proton STEAM spectroscopy ( 1 H-MRS). Method. Twelve with a diagnosis depressive episode, unipolar melancholic features (DSM-IV), enrolled, left was investigated...
Introduction In this study we assessed the contribution of psychopathology, including two domains negative symptoms (motivational deficit and expressive deficit), processing speed as an index neurocognition, emotion recognition, social cognition, to poor functional outcomes in people with schizophrenia. Methods The Positive Negative Syndrome Scale was used evaluate positive disorganization Brief Symptom assess symptoms. Symbol Coding Trail Making Test A B were rate Facial Emotion...
OBJECTIVE: Pharmacogenetic influences on therapeutic response to neuroleptic treatment are poorly understood. This study investigates the association of short-term haloperidol with a Taq I polymorphism in DRD2 gene. METHOD: Fifty-seven patients acute psychosis were treated for up 28 days. Improvement and measured by using Positive Negative Syndrome Scale. Forty-one homozygous allele 2, 16 heterozygous. RESULTS: Heterozygous showed greater improvement positive, but not negative, symptoms all...
Negative symptoms represent an unmet need of treatment in schizophrenia. Although a consensus exists on negative symptom construct, and second generation assessment instruments reflecting the are available, studies still rely upon old instruments, that do not reflect recent conceptualizations might limit progress search for effective treatments. This is often case European context, where one challenges encountered designing large availability validated many languages continent. To address...
The impact of long-term lithium treatment on weight gain has been a controversial topic with conflicting evidence. We aim to assess reporting associated and other mood stabilizers compared lamotrigine which is considered free metabolic adverse drug reactions (ADRs).We conducted case/non-case pharmacovigilance study using data from the AMSP project (German: "Arzneimittelsicherheit in der Psychiatrie"; i.e., Drug Safety Psychiatry), collects ADRs patients treated psychiatric hospitals Germany,...
Article AbstractBackground: Because a GABAergic hypofunction has been implied in the pathophysiology of mania, we have tested antimanic properties GABA transporter 1 inhibitor tiagabine.Method: An open trial was conducted 8 acutely manic inpatients with DSM-IV bipolar I disorder, 2 them tiagabine monotherapy and 6 as an add-on to previously insufficient mood-stabilizing medication. The study duration 14 days. Changes psychopathology were assessed by Bech-Rafaelsen Mania Rating Scale.Results:...
Negative symptoms are usually evaluated with scales based on observer ratings and up to now self-assessments have been overlooked. The aim of this paper was validate the Self-evaluation Symptoms (SNS) in a large European sample coming from 12 countries. We wanted demonstrate: (1) good convergent divergent validities; (2) relationships between SNS scores patients' functional outcome; (3) capacity compared Brief Symptom Scale (BNSS) detect negative symptoms; (4) five-domain construct relation...
Abstract Background Clinical practice suggests that older adults (i.e., ≥ 65 years of age) experience adverse drug reactions (ADRs) more often than younger patients < age). ADRs such as falls, extrapyramidal symptoms (EPS), metabolic disorders, sedation, and delirium are particularly worrisome associated with psychotropic drugs. Methods This observational study investigated the risk for drug-related in (n = 99,099) 363,562) psychiatric inpatients using data from German pharmacovigilance...
Carbohydrate‐deficient transferrin (CDT) and γ‐glutamyltransferase (GT) were evaluated as markers of alcohol dependency in two different groups patients. Sensitivity CDT was nearly 75% for patients hospitalized detoxification, but lower than 50% alcohol‐dependent admitted to acute surgery. correlated with self‐reported consumption both groups, sensitivity increased higher intake. females considerably males, although their not significantly different. Serum activity GT showed almost identical...