A5038468955- Helminth infection and control
- Parasite Biology and Host Interactions
- Coccidia and coccidiosis research
- Parasites and Host Interactions
- Antibiotics Pharmacokinetics and Efficacy
- Animal Nutrition and Physiology
- Veterinary Pharmacology and Anesthesia
- Pesticide Residue Analysis and Safety
- Pharmacological Effects and Assays
- Insect and Pesticide Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- Analytical Methods in Pharmaceuticals
- Parasitic Infections and Diagnostics
- Bacterial Identification and Susceptibility Testing
- Veterinary Equine Medical Research
- Bacterial biofilms and quorum sensing
- Drug Transport and Resistance Mechanisms
- Agricultural safety and regulations
- Antibiotic Use and Resistance
- Rice Cultivation and Yield Improvement
- Genetics and Plant Breeding
- Parasitic infections in humans and animals
- thermodynamics and calorimetric analyses
- Plant and fungal interactions
Centro Científico Tecnológico - Tandil
2012-2022
Consejo Nacional de Investigaciones Científicas y Técnicas
2006-2019
Health Research Institute of the Balearic Islands
2019
Universidad Nacional del Centro de la Provincia de Buenos Aires
2005-2014
Centro Científico Tecnológico - San Juan
2004-2011
International Center for Tropical Agriculture
2009
Philippine Rice Research Institute
2008
Centro Científico Tecnológico - Tucumán
2008
University of Córdoba
1996-2001
To undertake a Spanish nationwide survey on Pseudomonas aeruginosa molecular epidemiology and antimicrobial resistance. Up to 30 consecutive healthcare-associated P. isolates collected in 2017 from each of 51 hospitals were studied. MICs 13 antipseudomonal agents determined by broth microdilution. Horizontally acquired β-lactamases detected phenotypic methods PCR. Clonal was evaluated through PFGE MLST; at least one XDR isolate clone hospital (n = 185) sequenced. The most active...
Imipenem and imipenem-relebactam MICs were determined for 1,445 Pseudomonas aeruginosa clinical isolates a large panel of isogenic mutants showing the most relevant mutation-driven β-lactam resistance mechanisms. Imipenem-relebactam showed highest susceptibility rate (97.3%), followed by colistin ceftolozane-tazobactam (both 94.6%).
Background Soil Transmitted Helminth (STH) infections negatively impact physical and mental development in human populations. Current WHO guidelines recommend morbidity control of these through mass drug administration (MDA) using albendazole (ABZ) or mebendazole. Despite major reductions STH associated globally, not all programs have demonstrated the expected on prevalence parasite infections. These therapeutic failures may be related to poor programmatic coverage, suboptimal adherence...
The goals were to determine the ivermectin (IVM) plasma pharmacokinetics, tissue and egg residue profiles, in vitro metabolism laying hens. Experiments conducted (1) 8 hens intravenously treated with IVM blood samples taken; (2) 88 administered daily water (5 days) (40 kept their eggs collected; 48 sacrificed groups (n = 8) at different times taken analyzed); (3) biotransformation was studied liver microsomes. Pharmacokinetic parameters AUC 85.1 ng·day/mL, Vdss 4.43 L/kg, T1/2el 1.73 days....
In the search for novel influenza inhibitors we evaluated 7-fluoro-substituted indoles as bioisosteric replacements 7-azaindole scaffold of Pimodivir, a PB2 (polymerase basic protein 2) inhibitor currently in clinical development. Specifically, 5,7-difluoroindole derivative 11a was identified potent and metabolically stable inhibitor. demonstrated favorable oral pharmacokinetic profile vivo efficacy mice. addition, it found that not at risk metabolism via aldehyde oxidase, an advantage over...
Abstract Objectives To evaluate the correlation of O-antigen serotypes with resistance profiles and high-risk clones in a Spanish nationwide survey. Methods Up to 30 consecutive healthcare-associated Pseudomonas aeruginosa isolates were collected during October 2017 from each 51 hospitals (covering all regions) total 1445 studied. MICs 13 antipseudomonal agents MDR/XDR had been previously determined, as well whole-genome sequences 185 representative XDR isolates. (O1–O16) determined by...
Flubendazole (FLBZ) is a broad spectrum benzimidazole methylcarbamate anthelmintic widely used in poultry and swine. However, there no information available on the pharmacological behaviour of FLBZ ruminants. The work reported here was addressed to evaluate potential for use sheep. integrated assessment included evaluation metabolites plasma disposition kinetics, liver metabolism ex vivo ability diffuse into cestode parasite Moniezia benedeni . In cross‐over kinetic study, six healthy...
Flubendazole (FLBZ) is a poor water solubility broad-spectrum BZD methylcarbamate anthelmintic compound. Cyclodextrins (CDs) are usually used to increase aqueous of hydrosoluble compounds. The comparative in vitro FLBZ and other anthelmintics the presence hydroxypropyl-β-cyclodextrin (HPβCD) was evaluated current work. Additionally, pharmacokinetic behaviour (and its metabolites) administered by intraruminal (i.r.) or intraabomasal (i.a.) routes sheep as either an CDs-based solution...