A5041251499- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- Gastric Cancer Management and Outcomes
- Veterinary medicine and infectious diseases
- Eosinophilic Esophagitis
- Cytokine Signaling Pathways and Interactions
- Gastroesophageal reflux and treatments
- Clostridium difficile and Clostridium perfringens research
- Reproductive tract infections research
- Autoimmune Bullous Skin Diseases
- IL-33, ST2, and ILC Pathways
- Esophageal Cancer Research and Treatment
- Toxin Mechanisms and Immunotoxins
- Antifungal resistance and susceptibility
- Viral gastroenteritis research and epidemiology
- Lung Cancer Treatments and Mutations
- Microbial Metabolites in Food Biotechnology
- Pharmacological Effects of Natural Compounds
Institut Pasteur du Maroc
2016-2025
Gastric cancer is an inflammation-driven disease often associated with a bad prognosis. Upstream stimulatory factors USF1 and USF2 are pleiotropic transcription factors, tumor suppressor function. Low expression of low survival in gastric patients. genetic polymorphism -202G > A has been susceptibility. Our aim was to investigate gene serum level the risk cancer. USF1-202 G/A analyzed by sanger sequencing, measure USF1/USF2 levels ELISA H. pylori-positive patients chronic gastritis,...
Objective: Knowledge of local antibiotic resistance is crucial to the adaption effective empirical first-line treatment for Helicobacter Pylori (H. pylori) infection. This study aimed evaluate prevalence H. pylori clarithromycin and compare it with that metronidazole, highlight impact epidemiological factors gastric lesions severity on resistance. Methods: The susceptibility 96 isolates was determined by PCR-RFLP metronidazole 185 classic PCR. Result: Our results showed (14.6%) low compared...
Objective: Helicobacter pylori (H. pylori) induces the production of tumor necrosis factor-alpha (TNF-α), which is closely related to a gastric epithelial injury. TNF-α gene polymorphism and serum levels are associated with various malignant conditions. Identification ideal marker for cancer (GC) still leading aim several trials. Physio-pathological considerations GC led us investigate association two promoter polymorphisms (-308G>A -238G>A), susceptibility precancerous (PL) GC. Methods:...
Introduction: Cytotoxin associated gene A (CagA) and vacuolating cytotoxin (VacA) proteins are the main Helicobacter pylori virulence factors. These toxins with severe gastric diseases. Flavonoids plant secondary metabolites that have shown great antibacterial effects. This work aimed to study interaction of a set flavonoid compounds CagA VacA using molecular docking.Methods: 54 were used in this study, 36 which passed Lipinski rules 5. The 3D structures obtained from Protein Data Bank....
surveillance data on Helicobacter pylori (H. pylori) antibiotic susceptibilities in Morocco are limited, despite resistance being the key factor treatment failure. Virulence factors of H. associated with carcinogenesis and may be also efficacy treatment. The aim our study is to determine prevalence metronidazole a Moroccan population infected impact their virulence CagA VacA metronidazole.the susceptibility 185 isolates was determined by PCR. were genotyped for genes PCR.the rate 62.70%. No...
Background: H. pylori infection induce atrophic gastritis (AG) and intestinal metaplasia (IM) that can lead to gastric cancer (GC). The severity of lesions is related genetic diversity. oncogenic potential cagA virulence factor linked its high polymorphic EPIYA motifs.
 Objectives: Our aim was evaluate the association motifs with risk AG IM in Casablanca population.
 Methods: A total 210 patients suffering from (chronic gastritis, AG, IM) enrolled. type were diagnosed by ureC PCR...
Helicobacter pylori infection is the major risk factor of atrophic gastritis and intestinal metaplasia. The vacA gene one most virulence factors H. genetic diversity in its s, m, i, d regions associated with gastric lesions severity. This study aimed to investigate association metaplasia a Casablanca population.A total 210 patients suffering from (chronic gastritis, metaplasia) were enrolled. type lesion was diagnosed by histological examination. Detection genotyping carried out PCR.The...
the prevalence of Helicobacter pylori (H. pylori) infection in children is very high Morocco. Eradication rates H. decrease due to emergence resistance antibiotics. Data on antimicrobial susceptibility Moroccan are not available. This study aims assess and metronidazole rate pediatric patients, their association with epidemiologic factors.
Chronic inflammation due to H. pylori infection is the risk factor of gastric cancer (GC). Through its receptor (TNFR1), TNF- α plays a fundamental role in inflammatory, infectious, and tumor processes. Dysregulation TNFR1 gene expression could impact many biological processes that can lead cancer. This study aimed at evaluating association promoter polymorphisms (-580 A/G -609 G/T) serum levels with GC precancerous lesion susceptibility. Patients suffering from lesions (65 chronic...
Aims Helicobacter pylori (H. pylori) persistent infection lead to atrophic gastritis (AG) and intestinal metaplasia (IM) that can gastric cancer (GC). The severity of the lesions is related genetic variability H. virulence factors. cagA gene one most studied factors its oncogenic potential linked high polymorphic EPIYA motifs. aim this study was evaluate association motifs with risk AG IM in a Moroccan population.
Aims Helicobacter pylori infection is recognized as a worldwide problem, mainly in developing countries where reaches 80% of the population. H.pylori associated with various gastric diseases, mainly, many benign, premalignant, and malignant lesions mucosa. The aim our study was to determine prevalence asymptomatic population disease’s patients.