A5036447717- Hearing Loss and Rehabilitation
- Ear Surgery and Otitis Media
- Hearing, Cochlea, Tinnitus, Genetics
- Meningioma and schwannoma management
- Facial Nerve Paralysis Treatment and Research
- Olfactory and Sensory Function Studies
- Tracheal and airway disorders
- Obstructive Sleep Apnea Research
- Neurofibromatosis and Schwannoma Cases
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Head and Neck Surgical Oncology
- Vestibular and auditory disorders
- Prion Diseases and Protein Misfolding
- Neuroscience of respiration and sleep
- Congenital Ear and Nasal Anomalies
- Noise Effects and Management
- Nasal Surgery and Airway Studies
- Hearing Impairment and Communication
- Head and Neck Cancer Studies
- Biochemical Analysis and Sensing Techniques
- Cleft Lip and Palate Research
- Reconstructive Surgery and Microvascular Techniques
- Amyotrophic Lateral Sclerosis Research
University of Verona
2016-2025
Azienda Ospedaliera Universitaria Integrata Verona
2023-2025
University of Padua
2017-2024
University of Ferrara
2018
North American Skull Base Society
2000
Early and accurate in vivo diagnosis of Creutzfeldt-Jakob disease (CJD) is necessary for quickly distinguishing treatable from untreatable rapidly progressive dementias future therapeutic trials. This early becoming possible using the real-time quaking-induced conversion (RT-QuIC) seeding assay, which detects minute amounts disease-specific pathologic prion protein cerebrospinal fluid (CSF) or olfactory mucosa (OM) samples.To develop an algorithm CJD by RT-QuIC assay on CSF samples, OM...
Isolated REM sleep behaviour disorder (RBD) is an early-stage α-synucleinopathy in most, if not all, affected subjects. Detection of pathological α-synuclein peripheral tissues patients with isolated RBD may identify those progressing to Parkinson's disease, dementia Lewy bodies or multiple system atrophy, the ultimate goal testing preventive therapies. Real-time quaking-induced conversion (RT-QuIC) provided evidence seeding activity CSF and olfactory mucosa α-synucleinopathies. The aim this...
In patients with suspected dementia Lewy bodies, the detection of disease-associated α-synuclein in easily accessible tissues amenable to be collected using minimally invasive procedures remains a major diagnostic challenge. This approach has potential take advantage modern molecular assays for diagnosis α-synucleinopathy and, turn, optimize recruitment and selection clinical trials, drugs directed at counteracting aggregation. this study, we explored accuracy real-time quaking-induced...
The early and accurate in vivo diagnosis of sporadic Creutzfeldt–Jakob disease (sCJD) is essential order to differentiate CJD from treatable rapidly progressive dementias. Diagnostic investigations supportive clinical include magnetic resonance imaging (MRI), electroencephalogram (EEG), 14-3-3 protein detection, and/or real-time quaking-induced conversion (RT-QuIC) assay positivity the cerebrospinal fluid (CSF) or other tissues. total CSF tau concentration has also been used a setting for...
In patients with Parkinson's disease (PD), real-time quaking-induced conversion (RT-QuIC) detection of pathological α-synuclein (α-syn) in olfactory mucosa (OM) is not as accurate other α-synucleinopathies. It unknown whether these variable results might be related to a different distribution α-syn OM. Thus, we investigated nasal swab (NS) performed areas coverage by neuroepithelium, such agger nasi (AN) and middle turbinate (MT), affect the α-syn.NS was 66 PD 29 non-PD between September...
Objective To verify the possibility of auditory habilitation in children with aplasia and hypoplasia cochlear nerve by direct electrical stimulation nuclei an brainstem implant. Study Design Retrospective case review. Setting conducted at Ear, Nose, Throat Department University Verona, Italy. Patients Three children, aged 4, 3, 2 years, respectively, severe bilateral malformations have received implant this institution past years. Intervention The classic retrosigmoid approach was used....
The olfactory neuroepithelium is located in the upper vault of nasal cavity, lying on cleft and projecting into dorsal portion superior middle turbinates beyond mid-portion septum. It composed a variety cell types including sensory neurons, supporting glial-like cells, microvillar basal stem cells. cells are often intermingled with respiratory metaplastic epithelial Olfactory neurons undergo constant self-renewal timespan 2-3 months; they directly exposed to external environment, thus...
To describe our experience with the retrosigmoid-transmeatal (RS-TM) approach in auditory brainstem implantation (ABI) as well anatomosurgical guidelines for this route.Retrospective case review.Ear, Nose, and Throat Department of University Verona.Five patients neurofibromatosis type 2 (NF2) were operated on vestibular schwannoma removal ABI from April 1997 to June 1999. The four men one woman, whose ages ranged 22 37 years. tumor sizes 12 30 mm. records a total 179 (VS) via RS-TM January...
Abstract Fatal Familial Insomnia (FFI) is a genetic prion disease caused by point mutation in the protein gene ( PRNP ) characterized prominent thalamic atrophy, diffuse astrogliosis and moderate deposition of PrP Sc brain. Here, for first time, we demonstrate that olfactory mucosa (OM) patients with FFI contains trace amount detectable PMCA RT-QuIC. Quantitative analysis estimated concentration about 1 × 10 −14 g/ml. In contrast, was not detected OM samples from healthy controls affected...
Abstract Objective The detection of prion seeding activity in CSF and olfactory mucosal brushings using real‐time quaking‐induced conversion assays allows highly accurate clinical diagnosis sporadic Creutzfeldt–Jakob disease. To gauge transmission risks associated with these biospecimens their testing, we have bioassayed infectivity levels patients’ brain tissue, nasal brushings, CSF, assessed the pathogenicity amplified products seeded disease prions. Methods We obtained from patients a...
Abstract INTRODUCTION We assessed TAR DNA‐binding protein 43 (TDP‐43) seeding activity and aggregates detection in olfactory mucosa of patients with frontotemporal lobar degeneration TDP‐43‐immunoreactive pathology (FTLD‐TDP) by TDP‐43 amplification assay (TDP43‐SAA) immunocytochemical analysis. METHODS The TDP43‐SAA was optimized using frontal cortex samples from 16 post mortem cases FTLD‐TDP, FTLD tau inclusions, controls. Subsequently, were collected 17 15 healthy controls, three carrying...
Objective Vestibular schwannoma (VS) is a benign tumor of the lateral skull base. Different microscopic surgical techniques are described in literature: retrosigmoid and translabyrinthine approaches used to treat big tumors located cerebellopontine angle, middle cranial fossa approach utilized for small with good hearing preservation. The expanded transcanal transpromontorial (ExpTT) combined microscopic-endoscopic technique previously indicated Koos stage I II VS now proposed larger VS, up...
Objective: The objective of this study is to describe what we consider be the state-of-the-art procedure for treatment tympanic membrane perforations, and present results attained in our institution. Study Design: A retrospective cohort study, using data Verona University Hospital, Italy. This medical record includes 98 patients who underwent 100 transcanal endoscopic type I tympanoplasties from November 2014 October 2017. Setting: Tertiary referral center Hospital Verona, Patients: Were...
Introduction: Schwannomas are a common condition encountered in clinical ENT practice, but they rarely found the pharyngeal or laryngeal regions. Materials and Methods: In this report, we share our experience using transoral robotic approach to treat schwannoma located on lateral wall, with surgery being performed exclusively (TORS). It is important be aware of any pseudocystic lesions area, as can lead unpredictable anatomopathological outcomes. Results Conclusions: Our technique allows us...
Purpose: The purpose of this study was to evaluate the clinical and audiological outcomes in long-term cochlear implant (CI) users, focusing on hearing performance device failures. Methods: A retrospective conducted patients who underwent CI surgery, with a minimum follow-up 10 years. Device survival analyzed using Kaplan–Meier curves, failure rates were classified as explants or medical-related explants. time revision causes reimplantation assessed. Statistical analyses included Pearson...
Background/Objectives: The endoscopic repair of the tympanic membrane is an established method for addressing perforations in membrane. However, there are limited studies literature examining success rate this procedure pediatric population. Methods: This study retrospectively analyzed data from tertiary referral center at University Hospital Verona, Italy. medical record contains 84 type 1 transcanal tympanoplasties performed patients between November 2014 and February 2022. Seventy-seven...
Background/Objectives: Hearing loss represents an important communication barrier which can lead to social isolation and be a challenge for mental health status. It is generally accepted that hearing aid (HA) users develop stigma related despite the perceived benefits due most modern technologies. Nevertheless, toward HAs may persist even when patients have been well acclimatized their use. This study aims evaluate experiences in everyday life, underlying aspects utility of psychometric...
The current work examined a consecutive series of patients presenting vascular malformations (VMs) and venous lakes (VLs) the lip oral mucosa who were treated with transmucosal diode laser applications assessed over 1 year period.Fifty-nine (31 males 28 females) low-flow VMs or VLs cavity transmucosally using (with an 830 nm operating wavelength 1.6 W output power) 320 µm diameter flexible fiber. All lesions 7 days, 30 after treatment, lesion reduction percentage was scored on one to five...
Hypothesis: Electrical stimulation of the inferior colliculus in midbrain can provide a safe and efficacious alternative to auditory brainstem implants (ABIs). Background: Patients with neurofibromatosis type 2 (NF2) receive limited speech recognition ABIs. Some ABI patients without NF2 achieve excellent understanding, suggesting that performance is due damage from tumor its removal. Methods: An array electrodes (Med-El ABI) was placed on dorsal surface human volunteer as an prosthesis via...
It is reported that recovery from COVID-19 chemosensory deficit generally occurs in a few weeks, although olfactory dysfunction may persist longer. Here, we provide detailed follow-up clinical investigation very young female patient (17-year-old) with long-lasting anosmia after mild infection, partial 15 months the onset.Neuroimaging and neurophysiologic assessments as well mucosa swabbing for microbiological immunocytochemical analyses were performed. Olfactory gustatory evaluations...