A5012750616- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Mechanical Circulatory Support Devices
- Drug-Induced Hepatotoxicity and Protection
- Autoimmune and Inflammatory Disorders Research
- Respiratory Support and Mechanisms
- Drug Transport and Resistance Mechanisms
- Immune Cell Function and Interaction
- Fibroblast Growth Factor Research
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Lung Cancer Research Studies
- Acute Kidney Injury Research
- Inflammatory Biomarkers in Disease Prognosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Clusterin in disease pathology
- Autopsy Techniques and Outcomes
- Nosocomial Infections in ICU
- Hepatitis B Virus Studies
- Case Reports on Hematomas
- Chromatin Remodeling and Cancer
- Neonatal and Maternal Infections
- Inflammation biomarkers and pathways
- Diabetes, Cardiovascular Risks, and Lipoproteins
Shanghai Children's Hospital
2017-2025
Shanghai Jiao Tong University
2017-2025
Shanghai Sixth People's Hospital
2025
Sichuan University
2023
Kunming Medical University
2018
Abstract Background Advanced glycation end product receptor (RAGE) acts as a of pro-inflammatory ligands and is highly expressed in alveolar epithelial cells (AECs). Autophagy AECs has received much attention recently. However, the roles autophagy RAGE pathogenesis acute lung injury remain unclear. Therefore, this study aimed to explore whether activation signals take part dysfunction barrier through autophagic death. Methods Acute animal models were established using C57BL/6 Ager gene...
Uncontrollable inflammatory response acts as a driver of sepsis-associated liver injury (SALI). IL-22 plays an important role in regulating responses, but its SALI remains unknown. The aim the study was to assess association serum with pediatric patients and enclose underlying mechanisms involved lipopolysaccharide (LPS) - induced acute (ALI) mice. Serum levels were significantly lower than septic without injury, area under receiver operating characteristic (ROC) curve for discriminating...
Abstract Objective To investigate CD163 as an effective biomarker for identifying and predicting the outcomes of sepsis‐associated hemophagocytic lymphohistiocytosis (SAHS) in children. Methods We prospectively enrolled presumed sepsis patients who had developed prolonged fever (>7 days), hepatosplenomegaly, cytopenias, hyperferritinemia (>500 ng/mL) despite antibiotic therapy. Blood samples were collected within 24 hours after enrolment. A nested case–control study was performed. The...
The number of malignancy patients with respiratory failure is rising in pediatric intensive care units (PICU). Our study aims to compare the clinical characteristics and prognostic risk factors acute distress syndrome (ARDS) or without malignancies. This retrospective reviewed medical records 188 ARDS admitted PICU between January 2018 December 2022, including 60 malignancies 128 without. Clinical data were collected within 48 h post-ARDS diagnosis. Multivariate logistic regression analysis...
The study aimed to assess the clinical benefits of high-volume hemofiltration (HVHF) in pediatric patients with severe sepsis compared standard-volume continuous veno-venous (CVVH).We retrospectively analyzed medical records 155 admitted intensive care unit Shanghai Children's Hospital from January 2010 June 2016. A total 93 were treated HVHF and 62 CVVH.HVHF treatment did not significantly reduce 28-day mortality. Moreover, there was no significant difference reducing plasma level...
To summarize the pathogenic characteristics of bloodstream infection (BSI)-induced severe sepsis and analyze influence factors in pediatric intensive care unit (PICU).
Sepsis is extremely heterogeneous pathology characterized by complex metabolic changes. Fibroblast growth factor 19 (FGF19) a well-known intestine-derived inhibitor of bile acid biosynthesis. However, it largely unknown about the roles FGF19 in improving sepsis-associated disorder and organ injury. In present study, mice were intravenously injected recombinant human daily for 7 days followed lipopolysaccharide (LPS) administration. At 24 hours after LPS stimuli, sera collected metabolomic...
Sepsis induces the release of lipid mediators, which control both metabolism and inflammation. However, role serum apolipoprotein A-V (ApoA5) in sepsis is poorly understood pediatric patients.ApoA5 was screened from proteomics profile lipopolysaccharide- (LPS-) treated mice for 2 h, 24 controls. Then, we conducted a prospective pilot study, patients with admitted to intensive care unit (PICU) were enrolled January 2018 December 2018. Serum ApoA5 levels on PICU admission determined using...
Liver dysfunction is an independent risk factor for poor prognosis of patients with sepsis. The aim this study to evaluate the effects continuous hemofiltration in bacterial sepsis complicated by liver dysfunction. We retrospectively analyzed medical records 27 cases admitted pediatric intensive care unit (PICU) Shanghai Children's Hospital between January 2013 and December 2016. 28-day mortality length PICU stay were significantly reduced group (n = 16) compared conventional management 11)...
Abstract Background To assess the outcome of extracorporeal membrane oxygenation (ECMO) for severe adenovirus (Adv) pneumonia with refractory hypoxic respiratory failure (RHRF) in paediatric patients. Methods A retrospective observational study was performed a tertiary intensive care unit (PICU) China. Patients RHRF caused by Adv who received ECMO support after mechanical ventilation failed to achieve adequate between 2017 and 2020 were included. The variables in-hospital survival rate...
ATP citrate lyase (ACLY) is involved in lipid metabolism and inflammatory response immune cells. However, the serum level of ACLY its clinical relevance sepsis totally unknown.We conducted a prospective pilot study patients with admitted to pediatric intensive care unit (PICU) from January 2018 December 2018.Higher levels were detected sera than that healthy children. The area under receiver operating characteristic curve (AUC) for diagnosis was 0.855 (95% confidence interval [CI]:...
Abstract Background Thyroid hormone plays an important role in the adaptation of metabolic function to critically ill. The relationship between thyroid levels and outcomes septic shock is still unclear. aim this study was assess predictive value for prognosis pediatric shock. Methods We performed a prospective observational intensive care unit (PICU). Patients with were enrolled from August 2017 July 2019. Clinical laboratory indexes collected, measured on PICU admission. Results...
To study the epidemiological and pathological features of sudden death （SD） in Yunnan Province to provide scientific evidence for prevention forensic identification death.Totally 363 SD cases were collected from autopsies between 2009 2017 Forensic Centre Kunming Medical University. The related factors such as etiology, age, inducing factor, time interval onset disease death, morbidity season change retrospectively analysed.The incidence males was significantly higher than that females. peak...
Abstract Background: Fibroblast growth factor 19 (FGF19) secrets from intestinal epithelial cells and proved to be associated with functioning ileum in Crohn’s disease alcoholic steatohepatitis. In the present study, we aimed explore potential value of FGF19 as a biomarker for assessment gastrointestinal (GI) dysfunction pediatric patients sepsis.Methods: We performed prospective study enroll sepsis admitted intensive care unit (PICU) at Shanghai Children’s Hospital January 2018 December...
OBJECTIVE To investigate the effect and mechanism of 6-formylindolo[3,2-b]carbazole (FICZ) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. METHODS Male C57BL/6J mice aged 8-12 weeks were divided into 4 groups with 8 each group, according to method simple random sampling. Sepsis-induced ALI model was established by intraperitoneal injection LPS 5 mg/kg (LPS group), phosphate buffer saline (PBS) control group (PBS group) injected equal volume PBS. The LPS+FICZ intervened 1...
Objective To investigate the effects of lipopolysaccharide (LPS) on expressions sodium taurocholate co-transporting polypeptide (Ntcp) and bile salt export pump (Bsep), as well liver function markers in serum including total bilirubin (TBIL), acids (TBA), alanine aminotransferase (ALT), aspartate (AST) mice. Methods One hundred twenty-eight C57BL/6 mice were intra-peritoneally injected with different doses 5, 10, 20 or 40 mg/kg LPS (n=24), respectively. No treatment treated 0.9% NaCl...
Objective To investigate the effects and underlying mechanisms of methylprednisolone (MP) on liver injury induced by lipopolysaccharide (LPS). Methods Total 48 C57BL/6 mice (8-week old) were randomly divided into control group, LPS-induced endotoxemia model (1 h, 2 4 8 24 h) intervention group with MP therapy (n=6). Mice intraperitoneally injected withLPS (20 mg/kg) for indicated time h), (20mg/kg) was intraperitonealinjected micetointervene injury. Saline used as control....