A5051694798- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Conducting polymers and applications
- Neural dynamics and brain function
- Advanced Sensor and Energy Harvesting Materials
- Advanced Memory and Neural Computing
- Muscle activation and electromyography studies
- Gastrointestinal motility and disorders
- Epilepsy research and treatment
- Organic Electronics and Photovoltaics
- EEG and Brain-Computer Interfaces
- Genetics and Neurodevelopmental Disorders
- Infant Health and Development
- Neurological disorders and treatments
Columbia University
2021-2025
Columbia University Irving Medical Center
2021-2025
University of Cambridge
2024
Abstract Complementary transistors are critical for circuits with compatible input/output signal dynamic range and polarity. Organic electronics offer biocompatibility conformability; however, generation of complementary organic requires introduction separate materials inadequate stability potential tissue toxicity, limiting their use in biomedical applications. Here, we discovered that source/drain contact asymmetry enables spatial control de/doping creation single-material from a variety...
Epidermal electrophysiology is a non-invasive method used in research and clinical practices to study the electrical activity of brain, heart, nerves, muscles. However, electrode/tissue interlayer materials such as ionically conducting pastes can negatively affect recordings by introducing lateral electrode-to-electrode ionic crosstalk reducing spatial resolution. To overcome this issue, biocompatible, anisotropic-conducting composites (ACI) that establish an electrically anisotropic...
Abstract Gain-of-function (GoF) variants in the GRIN2D gene, encoding GluN2D subunit of N-methyl-D-aspartate receptor (NMDAR), cause a severe developmental and epileptic encephalopathy (DEE), characterized by intractable seizures, hypotonia, neurodevelopmental delay. We generated mice carrying GoF V664I variant, orthologous to V667I, which is present ∼25% GRIN2D-DEE patients. Heterozygous mutant demonstrate behavioral, neuroanatomical, electrophysiological abnormalities. Lethal convulsive...
Mature neural networks synchronize and integrate spatiotemporal activity patterns to support cognition. Emergence of these functions is believed be developmentally regulated, but the postnatal time course for perform complex computations remains unknown. We investigate progression large-scale synaptic cellular across development using high resolution in vivo electrophysiology immature mice. reveal that mature cortical processes emerge rapidly simultaneously after a discrete volatile...
Abstract Interictal epileptiform discharges (IEDs) are ubiquitously expressed in epileptic networks and disrupt cognitive functions. It is unclear whether addressing IED-induced dysfunction could improve epilepsy outcomes as most therapeutics target seizures. We show a model of progressive hippocampal that IEDs produce pathological oscillatory coupling which associated with prolonged, hypersynchronous neural spiking synaptically connected cortex expands the brain territory capable generating...
Abstract The gastrointestinal tract is regulated by a complex network of electrically-active cell types that communicate to drive gut function. One these systems, the enteric nervous system, represents primary point contact for host factors influence bodily health and behavior. This division autonomic system unique in both its extensivity, with neurons distributed throughout from esophagus rectum, capability local information processing. However, constant intrinsic extrinsic motion as well...
Neurologic and neuropsychiatric disorders substantially impact the pediatric population, but there is a lack of dedicated devices for monitoring developing brain in animal models, leading to gaps mechanistic understanding how functions emerge their disruption disease states. Due small size, fragility, high water content immature neural tissue, as well absence hardened skull mechanically support rigid devices, conventional interface are poorly suited acquire signals without inducing damage....
Modern implantable bioelectronics demand soft, biocompatible components that make robust, low-impedance connections with the body and circuit elements. Concurrently, such technologies must demonstrate high efficiency, ability to interface between body's ionic external electronic charge carriers. Here, a mixed-conducting suture, e-suture, is presented. Composed of silk, conducting polymer poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), insulating jacketing polymers,the...
Abstract Mature neural networks synchronize and integrate spatiotemporal activity patterns to support cognition. Emergence of these functions is believed be developmentally regulated, but the postnatal time course for perform complex computations remains unknown. We investigate progression large-scale synaptic cellular across development using high resolution in vivo electrophysiology immature mice. reveal that mature cortical processes emerge rapidly simultaneously after a discrete volatile...