A5029300756- Retinal Imaging and Analysis
- Corneal Surgery and Treatments
- Retinal and Optic Conditions
- Bone Tissue Engineering Materials
- Glaucoma and retinal disorders
- Facial Rejuvenation and Surgery Techniques
- Ocular Diseases and Behçet’s Syndrome
- Periodontal Regeneration and Treatments
- Reconstructive Facial Surgery Techniques
- Wound Healing and Treatments
- Corneal surgery and disorders
- Ocular Disorders and Treatments
- Medical Image Segmentation Techniques
- Ophthalmology and Visual Impairment Studies
- Ocular Surface and Contact Lens
- Retinal Diseases and Treatments
- Ocular Infections and Treatments
- Catalytic Processes in Materials Science
- Digital Imaging for Blood Diseases
- Silk-based biomaterials and applications
- Graphene and Nanomaterials Applications
- Osteoarthritis Treatment and Mechanisms
- Industrial Vision Systems and Defect Detection
- Fibroblast Growth Factor Research
- Estrogen and related hormone effects
Second Affiliated Hospital of Zhejiang University
2017-2025
Zhejiang University
2019-2025
Chinese Academy of Sciences
2007-2020
Hangzhou Academy of Agricultural Sciences
2019-2020
University of Chinese Academy of Sciences
2020
Kunming Institute of Zoology
2019-2020
University of Science and Technology of China
2020
University of California, Davis
2012
Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here, we report that genes involved various human cancers evolved rapidly Tibetans six Tibetan domestic mammals compared to reciprocal lowlanders. Furthermore, m6A modified mRNA binding protein YTHDF1, one of evolutionary positively selected for high-altitude adaptation is amplified cancers, including non-small cell lung cancer (NSCLC). We show YTHDF1 deficiency inhibits NSCLC proliferation xenograft tumor...
The aligned scaffolds facilitate migration of endogenous reparative cells, leading to better regeneration osteochondral defects.
Purpose: Lung cancer is the leading cause of related deaths worldwide.We have previously identified many differentially expressed genes (DEGs) from large scale pan-cancer dataset using Cross-Value Association Analysis (CVAA) method.Here we focus on Progestin and AdipoQ Receptor 4 (PAQR4), a member progestin adipoQ receptor (PAQR) family localized in Golgi apparatus, to determine their clinical role mechanism development non-small cell lung (NSCLC).Methods: The protein expression profile...
Eye disease burden could help guide health policy making. Differences in cataract by sex is a major concern of reducing avoidable blindness caused cataract.To investigate the association with global year, age, and socioeconomic status using disability-adjusted life-years (DALYs).This international, comparative burden-of-disease study extracted global, regional, national sex-specific DALY numbers, crude rates, age-standardized rates year age from Global Burden Disease Study 2015. The data...
This study aimed to propose a fully automatic eyelid measurement system and compare the contours of both upper lower eyelids normal individuals according age gender.
Infectious keratitis (IK) is a common ophthalmic emergency that requires prompt and accurate treatment. This study aimed to propose deep learning (DL) system based on slit lamp images automatically screen diagnose infectious keratitis. established dataset of 2757 from 744 patients, including normal cornea, viral (VK), fungal (FK), bacterial (BK). Six different DL algorithms were developed evaluated for the classification Among all models, EffecientNetV2-M showed best ability, with an...
Abstract Background/aims Early recognition of eyelid morphological abnormalities was crucial, as untreated conditions could lead to blinding complications. An screening system that provide both anatomical and pathological information essential for formulating personalized treatment strategies. This study aimed develop a clinically concerns-based framework capable identifying common diseases requiring further intervention by evaluating individual changes. approach would enhance individualized...
<title>Abstract</title> In the field of medical object detection, acquiring abundant high-quality data remains a critical challenge. To address this issue, we propose DABDM (Data Augmentation Based on Diffusion Model), semi-supervised detection framework that exploits diffusion models to enhance image datasets. Our approach generates large volume synthetic images, which are utilized for unsupervised training phase in learning, thereby mitigating reliance extensive labeled data. Experimental...
The modulation of inflammation in tissue microenvironment takes an important role cartilage repair and regeneration. In this study, a novel hybrid scaffold was designed fabricated by filling reactive oxygen species (ROS)-scavenging hydrogel (RS Gel) into radially oriented poly(lactide-co-glycolide) (PLGA) scaffold. PLGA scaffolds were through temperature gradient-guided phase separation freeze-drying method. RS Gel formed crosslinking the mixture ROS-responsive hyperbranched polymers...
An aggrecanase-1 (ADAMTS4)-degradable and HAV sequence-tethered hydrogel is designed to enhance the regeneration of osteochondral defects by regulating degradation cell–cell interactions.
Clinical application of artificial intelligence is limited due to the lack interpretability and expandability in complex clinical settings. We aimed develop an eye diseases screening system with improved based on a lesion-level dissection tested auxiliary ability system.The four-hierarchical interpretable (IEDSS) novel structural pattern named lesion atlas was developed identify 30 conditions using total 32,026 ultra-wide field images collected from Second Affiliated Hospital Zhejiang...
Abstract Infectious keratitis is among the major causes of global blindness. Anterior segment optical coherence tomography (AS-OCT) images allow characterizing cross-sectional structures in cornea with thus revealing severity inflammation, and can also provide 360-degree information on anterior chambers. The development image analysis methods for such cases, particularly deep learning methods, requires a large number annotated images, but to date, there no open-access AS-OCT repository. For...
The study aimed to evaluate the effect of drooped eyelid on corneal tomography in congenital blepharoptosis patients. Sixty-four patients with and 64 age- sex- matched healthy subjects were included. According margin light reflex distance (MRD), eyes categorized as mild, moderate, or severe. scanned using rotating Scheimpflug camera. Increased topometric parameters observed moderate severe blepharoptosis. Back elevations at thinnest point significant higher for mild (P = 0.009), < 0.001),...