A5006135708- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Neuroblastoma Research and Treatments
- Estrogen and related hormone effects
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Microtubule and mitosis dynamics
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Treatment and Pharmacology
- Cancer-related Molecular Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Melanoma and MAPK Pathways
- Colorectal Cancer Screening and Detection
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Colorectal and Anal Carcinomas
- Stress Responses and Cortisol
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
University of Colorado Anschutz Medical Campus
2015-2025
University of Colorado Denver
2015-2024
University of Colorado Cancer Center
2015-2024
University of Colorado Hospital
2021
University of North Carolina at Chapel Hill
2020
Durham VA Medical Center
2017-2019
Duke University Hospital
2019
Duke Medical Center
2019
Duke University
2017-2018
Mental Illness Research, Education and Clinical Centers
2018
Alpha-dystroglycan (alpha-DG) is a cell-surface glycoprotein that acts as receptor for both extracellular matrix proteins containing laminin-G domains and certain arenaviruses. Receptor binding thought to be mediated by posttranslational modification, defective with laminin underlies subclass of congenital muscular dystrophy. Using mass spectrometry- nuclear magnetic resonance (NMR)-based structural analyses, we identified phosphorylated O-mannosyl glycan on the mucin-like domain recombinant...
Vantictumab is a fully human monoclonal antibody that inhibits Wnt pathway signaling through binding FZD1, 2, 5, 7, and 8 receptors. This phase Ib study evaluated vantictumab in combination with nab-paclitaxel gemcitabine patients untreated metastatic pancreatic adenocarcinoma. Patients received at escalating doses standard dosing of according to 3 + design. A total 31 were treated 5 cohorts. Fragility fractures attributed occurred 2 Cohort (7 mg/kg every weeks), this maximum administered...
BACKGROUND. MEK inhibitors have limited activity in biliary tract cancers (BTCs) as monotherapy but are hypothesized to enhance responses programmed death ligand 1 (PD-L1) inhibition.
Background Smaller hippocampal volume in patients with posttraumatic stress disorder (PTSD) represents the most consistently reported structural alteration brain. Subfields of hippocampus play distinct roles encoding and processing memories, which are disrupted PTSD. We examined PTSD-associated alterations 12 subfields relation to global shape, clinical features. Methods Case-control cross-sectional studies U.S. military veterans (n = 282) from Iraq Afghanistan era were grouped into PTSD...
229 Background: Current data suggest that combining tyrosine kinase inhibitors with immune checkpoint may be a promising treatment strategy in patients metastatic MSS CRC. This prospective, open-label, single-arm, phase II study (NCT04963283) evaluated the efficacy of cabozantinib combination nivolumab refractory Methods: Patients metastatic/unresectable CRC who were to chemotherapy 3 rd line setting and beyond eligible. treated 40 mg orally daily 480 IV every 28 days. Tumor assessments...
Genetic mutations in a number of putative glycosyltransferases lead to the loss glycosylation dystroglycan and its laminin-binding activity genetic forms human muscular dystrophy. Human patients defective myd mice develop cardiomyopathy with matrix receptor function both striated smooth muscle.To determine functional role cardiac muscle development dystrophies.Using cre/lox-mediated gene targeting, we show here that ventricular myocytes is sufficient induce progressive characterized by focal...
The Aurora kinases are a family of serine/threonine comprised A, B, and C which execute critical steps in mitotic meiotic progression. Alisertib (MLN8237) is an investigational A selective inhibitor that has demonstrated activity against wide variety tumor types vitro vivo, including CRC.CRC cell lines varying sensitivity to alisertib with IC50 values ranging from 0.06 > 5 umol/L. Following exposure we observed decrease pAurora B four CRC lines. We also increase p53 p21 sensitive wildtype...
AZD0156 is an oral inhibitor of ATM, a serine threonine kinase that plays key role in DNA damage response (DDR) associated with double-strand breaks. Topoisomerase-I irinotecan used clinically to treat colorectal cancer (CRC), often combination 5-fluorouracil (5FU). and 5FU was evaluated preclinical models CRC determine whether low doses enhance the cytotoxicity chemotherapy regimens clinic.Anti-proliferative effects single-agent AZD0156, active metabolite (SN38), therapy were 12 cell lines....
Abstract The goal of this study was to investigate the activity selective MEK1/2 inhibitor TAK-733 in both melanoma cell lines and patient-derived xenograft models. In vitro proliferation assays using sulforhodamine B assay were conducted determine potency responsiveness. vivo murine modeling with eleven explants evaluated daily dosing at 25 or 10 mg/kg. Immunoblotting performed evaluate on-target downstream inhibition by studies. demonstrated broad most relative resistance observed IC50...
105 Background: GDC-0919, a small molecule inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), reduces tryptophan catabolism and kynurenine production within the tumor microenvironment that may promote normal effector T cell activity an immunogenic state. IDO1 inhibition complement targeting PD-L1 with atezolizumab. Methods: A Phase Ib, open-label, study assessed safety, pharmacokinetics (PK), pharmacodynamics (PD), anti-tumor (RECIST v1.1) GDC-0919 atezolizumab in pts locally advanced or...
Use of neoadjuvant therapy for elderly patients with pancreatic cancer has been debatable. With FOLFIRINOX (folinic acid, 5-fluorouracil, irinotecan, oxaliplatin) or gemcitabine plus nab-paclitaxel (GnP) showing tremendous effects in improving the overall survival borderline resectable and locally advanced cancer, there is no definitive consensus regarding use this regimen elderly.This study evaluated eligibility therapy. Patients registered database at University Colorado Cancer Center, who...
Aurora A kinase and MEK inhibitors induce different, potentially complementary, effects on the cell cycle of malignant cells, suggesting a rational basis for utilizing these agents in combination. In this work, combination an inhibitor was evaluated pre-clinical colorectal cancer models, with focus identifying subpopulation which it might be most effective. Increased synergistic activity drug identified lines concomitant KRAS PIK3CA mutations. Anti-proliferative were observed upon treatment...
Abstract Depending on the traumatic event, a significant fraction of trauma survivors subsequently develop PTSD. The additional variability in PTSD risk is expected to arise from genetic susceptibility. Unfortunately, several genome-wide association studies (GWAS) have failed identify consistent marker for heritability intermediate phenotypes such as regional brain volumes often 80% or higher. We conducted GWAS subcortical sample recent military veteran ( n = 157), grouped into 66) and...
Abstract Purpose: The purpose of this study was to evaluate the rational combination TORC1/2 inhibitor TAK-228 and Aurora A kinase alisertib in preclinical models triple-negative breast cancer (TNBC) conduct a phase I dose escalation trial patients with advanced solid tumors. Experimental Design: TNBC cell lines patient-derived xenograft (PDX) were treated alisertib, TAK-228, or evaluated for changes proliferation, cycle, mTOR pathway modulation, terminal cellular fate, including apoptosis...
Posttraumatic stress disorder (PTSD) is a prevalent, chronic with high psychiatric morbidity; however, substantial portion of affected individuals experience remission after onset. Alterations in brain network topology derived from cortical thickness correlations are associated PTSD, but the effects remitted symptoms on remain essentially unexplored. In this cross-sectional study, US military veterans (N = 317) were partitioned into three diagnostic groups, current PTSD (CURR-PTSD, N 101),...