A5021928568- Cardiac Arrest and Resuscitation
- Acute Kidney Injury Research
- Receptor Mechanisms and Signaling
- Renal Diseases and Glomerulopathies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Eicosanoids and Hypertension Pharmacology
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Disaster Response and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Vasculitis and related conditions
- Renin-Angiotensin System Studies
- Biochemical Acid Research Studies
Texas Tech University
2014-2017
Texas Tech University Health Sciences Center
2014-2017
Importance In prior monotherapy studies of patients with hypertension, single subcutaneous doses zilebesiran, an investigational RNA interference therapeutic, reduced serum angiotensinogen levels and systolic blood pressure (SBP) at 3 6 months. Objective To evaluate the efficacy safety zilebesiran vs placebo when added to a standard antihypertensive medication. Design, Setting, Participants This phase 2, randomized, prospective, double-blinded trial enrolled adults uncontrolled hypertension...
Pauci-immune crescentic glomerulonephritis (PICGN) is most commonly associated with antineutrophil cytoplasmic antibodies (ANCA). We report a case of chronic, sclerosing ANCA-negative PICGN discovered when patient presented multiple myeloma. A 57-year-old woman complaints nausea, emesis and weakness. She was found to be in renal failure serum creatinine 9.4 mg/dl, mild hyperkalemia acidosis. noted have normochromic, normocytic anemia normal platelet white cell counts, plasma proteins protein...
Low-solute hyponatremia is a relatively uncommon entity of euvolemic hyponatremia. Classic cases were described in alcoholics as beer potomania, which characterized by the setting low-solute intake due to heavy drinking. We report case nonalcoholic person who was given solute load, and, subsequently, had excessive diuresis with resultant rapid increase serum sodium concentration.
Background: Acute kidney injury (AKI) is often one component of multiple organ failure (MOF) in the intensive care unit (ICU). However, not all patients with MOF develop AKI, and AKI may absence MOF. We compared impact alone combination on survival admitted to a large tertiary medical (MICU). Methods: abstracted data from electronic records MICU April 2012 through June 2013 categorized as either high-risk or low- risk status based use vasopressor support mechanical ventilation during ICU...