A5076055220- Antimicrobial agents and applications
- Antimicrobial Peptides and Activities
- Polydiacetylene-based materials and applications
- Wound Healing and Treatments
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Electrospun Nanofibers in Biomedical Applications
- Advanced Drug Delivery Systems
- Silk-based biomaterials and applications
- Nanocomposite Films for Food Packaging
- Advanced Cellulose Research Studies
- Dye analysis and toxicity
- biodegradable polymer synthesis and properties
- Nanoparticle-Based Drug Delivery
- Dendrimers and Hyperbranched Polymers
- Biopolymer Synthesis and Applications
- DNA and Nucleic Acid Chemistry
- Pluripotent Stem Cells Research
- Nanoparticles: synthesis and applications
- Dyeing and Modifying Textile Fibers
- Graphene and Nanomaterials Applications
- Parasite Biology and Host Interactions
- Polymer-Based Agricultural Enhancements
- Ultrasound and Hyperthermia Applications
- Proteoglycans and glycosaminoglycans research
University of Geneva
2016-2025
HES-SO University of Applied Sciences and Arts Western Switzerland
2019-2025
University of Oxford
2021-2024
Institute of Biomedical Science
2024
Science Oxford
2021
University of Lausanne
2014-2019
West University of Timişoara
2012-2016
Hyaluronic acid (HA) has been known to play an important role in wound healing process. However, the effect of molecular weight (MW) exogenously administered HA on process not fully understood. In this study, we investigated with different MWs using human epidermal keratinocytes and dermal fibroblasts. Cell proliferation migration ability were assessed by water soluble tetrazolium (WST) assay scratch assay. We examined addition a full-thickness model mice gene expression related healing....
A sound, reliable, time- and cost-efficient method for detection of reducing sugars, based on the well known dinitrosalicylic acid (DNS) colorimetric method, adapted microtiter plates, in a modified water bath with microwave treatment is proposed. Besides benefic influence environment due to reduction volume reagents, rapid allows analysis relatively high number samples. It can be applied many types laboratories from food processing pharmaceutical industries. The was partially validated...
The paper examines copper ion removal and recovery from mining waters using chitosan cross-linked beads as insoluble sorbents in acidic basic solutions. Batch adsorption experiments were carried out a function of pH, adsorbent dosage, contact time, initial Cu(II) concentration. Equilibrium data fitted Langmuir, Freundlich, Elovich, Temkin models. experimental best represented by pseudo-second order kinetic model Langmuir isotherm model. Recovery ions was successfully achieved treating with...
We report herein a new chemical platform for coupling chitosan derivatives to antimicrobial peptide dendrimers (AMPDs) with different degrees of ramification and molecular weights via thiol-maleimide reactions. Previous studies showed that simple incorporation AMPDs polymeric hydrogels resulted in loss antibacterial activity augmented cytotoxicity mammalian cells. have shown enabled the two compounds act synergistically. was preserved when incorporating AMPD conjugates into various...
Abstract The burden of bacterial wound infections has considerably increased due to antibiotic resistance most the currently available antimicrobial drugs. Herein, for first time, a chemical coupling two cationic N ‐aryl (pyridyl and aminocinnamyl) chitosan derivatives peptide dendrimers (AMPDs) different generations (first, second, third) via thioether‐haloacetyl reaction is reported. new chitosan‐AMPD conjugates show high selectivity by killing Pseudomonas aeruginosa very low toxicity...
Super hydrophilic scaffolds of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) with 3 wt % acetylated (CNC-Ac) and PEGylated (CNC-PEG) cellulose nanocrystals (CNC) were prepared. PHBV, PHBV/CNC-Ac, PHBV/CNC-PEG characterized respect to their morphology by scanning electron microscopy (SEM) X-ray microtomography. The crystallinity was evaluated differential calorimetry (DSC) the mechanical properties uniaxial compression tests. presence residual solvent identified gas chromatography (GC),...
The success of medical threatments with DNA and silencing interference RNA is strongly related to the design efficient delivery technologies. Cationic polymers represent an attractive strategy serve as nucleic-acid carriers envisioned advantages complexation, low cost, ease production, well-defined size, polydispersity index. However, balance between efficacy toxicity (safety) these a challenge in need improvement. With aim designing more effective polycationic-based gene carriers, many...
Bacterial infections occur when wound healing fails to reach the final stage of healing, usually hindered by presence different pathogens. Different topical antimicrobial agents are used inhibit bacterial growth due antibiotic failure in reaching infected site accompanied very often an increased drug resistance and other side effects. In this review, we focus on peptides (AMPs), especially those with a high potential efficacy against multidrug-resistant biofilm-forming bacteria fungi present...
The crisis of antimicrobial resistance (AMR) increases dramatically despite all efforts to use available antibiotics or last resort agents. spread the AMR, declared as one most important health-related issues, warrants development new strategies.
A simple and rapid analytical method for the simultaneous quantification of three commercial azo dyes—Tartrazine (TAR), Congo Red (CR), Amido Black (AB) in water is presented. The assessment individual concentration an organic dye mixtures using a spectrophotometric difficult procedure chemistry, due to spectral overlapping. This drawback can be overcome if multivariate calibration such as Partial Least Squares Regression (PLSR) used. study presents model based on absorption spectra 300 -...
Amphiphilic cyclodextrins are biocompatible oligosaccharides that can be used for drug delivery especially the of drugs with solubility problems thanks to their unique molecular structures. In this paper, Paclitaxel was as a model anticancer determine inclusion complex properties amphiphilic different surface charge. Paclitaxel-loaded cyclodextrin nanoparticles were characterized in terms mean particle diameter, zeta potential, encapsulation efficacy, release profile and cell culture...
Implant-associated infections are highly challenging to treat, particularly with the emergence of multidrug-resistant microbials. Effective preventive action is desired be at implant site. Surface biofunctionalization implants through Ag-doping has demonstrated potent antibacterial results. However, it may adversely affect bone regeneration high doses. Benefiting from potential synergistic effects, combining Ag other agents can substantially decrease required concentration. To date, no study...
Abstract Dimethylsulfoxide (DMSO) has conventionally been used for cell cryopreservation both in research and clinical applications, but long-term cytotoxic effects. Trehalose, a natural disaccharide, proposed as non-toxic cryoprotectant. However, the lack of specific membrane transporter receptors inhibits transmembrane transport severely limits its cryoprotective capability. This presents method to successfully deliver trehalose into mesenchymal stem cells (MSCs) using ultrasound presence...
The efficacy of transfection vectors to cross the endosomal membrane into cytosol is a central aspect in development nucleic acid-based therapeutics. challenge remains same: Delivery, Delivery. Despite rational and appropriate construct triblock polymeric micelles, which could serve as an ideal platform for co-delivery siRNAs hydrophobic anticancer drugs, we show here its inability properly convey oligonucleotides their final destination. In order overcome biological barriers, linear PEI...