- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Diet, Metabolism, and Disease
- Neonatal Respiratory Health Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrospinal fluid and hydrocephalus
- Erythrocyte Function and Pathophysiology
- Neurological Disease Mechanisms and Treatments
- Family Caregiving in Mental Illness
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Neuroblastoma Research and Treatments
- Alzheimer's disease research and treatments
- Mental Health Treatment and Access
- Receptor Mechanisms and Signaling
- Retinal Development and Disorders
- Neurological Disorders and Treatments
- Mental Health and Patient Involvement
- Developmental Biology and Gene Regulation
Rosalind Franklin University of Medicine and Science
2024
Loyola University Chicago
2024
Arizona State University
2019-2023
Michigan State University
2023
University of Arizona
2023
Tempe Union High School District
2022
Creighton University
2018
University of Manchester
2016
Currently, there are no effective therapies to ameliorate the pathological progression of Alzheimer's disease (AD). Evidence suggests that environmental factors may contribute AD. Notably, dietary nutrients suggested play a key role in mediating mechanisms associated with brain function. Choline is B-like vitamin nutrient found common foods important various cell functions. It serves as methyl donor and precursor for production membranes. also acetylcholine, neurotransmitter which activates...
Abstract Many developmental syndromes have been linked to genetic mutations that cause abnormal ERK/MAPK activity; however, the neuropathological effects of hyperactive signaling are not fully understood. Here, we examined whether hyperactivation MEK1 modifies development GABAergic cortical interneurons (CINs), a heterogeneous population inhibitory neurons necessary for function. We show GABAergic-neuron specific in vivo leads increased cleaved caspase-3 labeling subpopulation immature...
RAS/MAPK gene dysfunction underlies various cancers and neurocognitive disorders. While the role of genes have been well studied in cancer, less is known about their function during neurodevelopment. There are many that work concert to regulate signaling, suggesting if common brain phenotypes could be discovered they a broad impact on other disorders caused by distinct genes. We assessed cellular molecular consequences hyperactivating pathway using two cell type previously implicated...
Introduction Collaborative mental healthcare (CMHC) has garnered worldwide interest as an effective, team-based approach to managing common disorders in primary care. However, questions remain about how CMHC works and why it some circumstances but not others. In this study, we will review the evidence on one understudied potentially critical component of CMHC, namely engagement patients families Our aims are describe strategies used engage people with depression or anxiety their understand...
Abstract RAS/MAPK gene dysfunction underlies various cancers and neurocognitive disorders. While the role of genes have been well studied in cancer, less is known about their function during neurodevelopment. There are many that work concert to regulate signaling, suggesting if common brain phenotypes could be discovered they a broad impact on other disorders caused by distinct genes. We assessed cellular molecular consequences hyperactivating pathway using two cell type previously...
The RAS/RAF/MEK/ERK1/2 intracellular signaling pathway is activated by numerous cues during brain development and dysregulated in neurodevelopmental syndromes, particularly the RASopathies certain forms of autism. Cortical excitatory/inhibitory imbalance thought to be critical neuropathogenesis these conditions. However, developmental functions ERK1/2 cortical inhibitory neurons (CINs) other medial ganglionic eminence (MGE)-derived non-neuronal cells are poorly understood. Here, we...
The RAS/RAF/MEK/ERK1/2 intracellular signaling pathway is activated by numerous cues during brain development and dysregulated in neurodevelopmental syndromes, particularly the RASopathies certain forms of autism. Cortical excitatory/inhibitory imbalance thought to be critical neuropathogenesis these conditions. However, developmental functions ERK1/2 cortical inhibitory neurons (CINs) other medial ganglionic eminence (MGE)-derived non-neuronal cells are poorly understood. Here, we...
The CTC1-STN1-TEN1 (CST) complex is a single-strand DNA-binding protein that plays an important role in genome maintenance various model eukaryotes. Dysfunction of CST the underlying cause rare genetic disorder known as Coats plus disease. In addition, down regulation STN1 promotes colorectal cancer development mice. While prior studies have utilized RNAi to knock components mammalian cells, this approach associated with off-target effects. Attempts employ CRISPR/Cas9-based knockout somatic...
Abstract The RAS/RAF/MEK/ERK1/2 intracellular signaling pathway is activated by numerous cues during brain development and dysregulated in neurodevelopmental syndromes, particularly the RASopathies certain forms of autism. Cortical excitatory/inhibitory imbalance thought to be critical neuropathogenesis these conditions. However, developmental functions ERK1/2 cortical inhibitory neurons (CINs) other medial ganglionic eminence (MGE)-derived non-neuronal cells are poorly understood. Here, we...