Sara Knowles

ORCID: 0000-0003-3906-8195
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About
Contact & Profiles
Research Areas
  • Neurogenesis and neuroplasticity mechanisms
  • Neuroscience and Neuropharmacology Research
  • Nerve injury and regeneration
  • Diet, Metabolism, and Disease
  • Neonatal Respiratory Health Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cerebrospinal fluid and hydrocephalus
  • Erythrocyte Function and Pathophysiology
  • Neurological Disease Mechanisms and Treatments
  • Family Caregiving in Mental Illness
  • Adipose Tissue and Metabolism
  • Diet and metabolism studies
  • Neuroblastoma Research and Treatments
  • Alzheimer's disease research and treatments
  • Mental Health Treatment and Access
  • Receptor Mechanisms and Signaling
  • Retinal Development and Disorders
  • Neurological Disorders and Treatments
  • Mental Health and Patient Involvement
  • Developmental Biology and Gene Regulation

Rosalind Franklin University of Medicine and Science
2024

Loyola University Chicago
2024

Arizona State University
2019-2023

Michigan State University
2023

University of Arizona
2023

Tempe Union High School District
2022

Creighton University
2018

University of Manchester
2016

Currently, there are no effective therapies to ameliorate the pathological progression of Alzheimer's disease (AD). Evidence suggests that environmental factors may contribute AD. Notably, dietary nutrients suggested play a key role in mediating mechanisms associated with brain function. Choline is B-like vitamin nutrient found common foods important various cell functions. It serves as methyl donor and precursor for production membranes. also acetylcholine, neurotransmitter which activates...

10.1111/acel.13037 article EN cc-by Aging Cell 2019-09-27

Abstract Many developmental syndromes have been linked to genetic mutations that cause abnormal ERK/MAPK activity; however, the neuropathological effects of hyperactive signaling are not fully understood. Here, we examined whether hyperactivation MEK1 modifies development GABAergic cortical interneurons (CINs), a heterogeneous population inhibitory neurons necessary for function. We show GABAergic-neuron specific in vivo leads increased cleaved caspase-3 labeling subpopulation immature...

10.1093/cercor/bhaa413 article EN Cerebral Cortex 2020-12-25

RAS/MAPK gene dysfunction underlies various cancers and neurocognitive disorders. While the role of genes have been well studied in cancer, less is known about their function during neurodevelopment. There are many that work concert to regulate signaling, suggesting if common brain phenotypes could be discovered they a broad impact on other disorders caused by distinct genes. We assessed cellular molecular consequences hyperactivating pathway using two cell type previously implicated...

10.1242/dev.201371 article EN cc-by Development 2023-05-11

Introduction Collaborative mental healthcare (CMHC) has garnered worldwide interest as an effective, team-based approach to managing common disorders in primary care. However, questions remain about how CMHC works and why it some circumstances but not others. In this study, we will review the evidence on one understudied potentially critical component of CMHC, namely engagement patients families Our aims are describe strategies used engage people with depression or anxiety their understand...

10.1136/bmjopen-2016-012949 article EN cc-by-nc BMJ Open 2016-09-01

Abstract RAS/MAPK gene dysfunction underlies various cancers and neurocognitive disorders. While the role of genes have been well studied in cancer, less is known about their function during neurodevelopment. There are many that work concert to regulate signaling, suggesting if common brain phenotypes could be discovered they a broad impact on other disorders caused by distinct genes. We assessed cellular molecular consequences hyperactivating pathway using two cell type previously...

10.1101/2022.08.04.502867 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2022-08-05

The RAS/RAF/MEK/ERK1/2 intracellular signaling pathway is activated by numerous cues during brain development and dysregulated in neurodevelopmental syndromes, particularly the RASopathies certain forms of autism. Cortical excitatory/inhibitory imbalance thought to be critical neuropathogenesis these conditions. However, developmental functions ERK1/2 cortical inhibitory neurons (CINs) other medial ganglionic eminence (MGE)-derived non-neuronal cells are poorly understood. Here, we...

10.7554/elife.88313.1 preprint EN 2023-07-21

The RAS/RAF/MEK/ERK1/2 intracellular signaling pathway is activated by numerous cues during brain development and dysregulated in neurodevelopmental syndromes, particularly the RASopathies certain forms of autism. Cortical excitatory/inhibitory imbalance thought to be critical neuropathogenesis these conditions. However, developmental functions ERK1/2 cortical inhibitory neurons (CINs) other medial ganglionic eminence (MGE)-derived non-neuronal cells are poorly understood. Here, we...

10.7554/elife.88313 preprint EN 2023-07-21

The CTC1-STN1-TEN1 (CST) complex is a single-strand DNA-binding protein that plays an important role in genome maintenance various model eukaryotes. Dysfunction of CST the underlying cause rare genetic disorder known as Coats plus disease. In addition, down regulation STN1 promotes colorectal cancer development mice. While prior studies have utilized RNAi to knock components mammalian cells, this approach associated with off-target effects. Attempts employ CRISPR/Cas9-based knockout somatic...

10.21769/bioprotoc.4977 article EN cc-by-nc BIO-PROTOCOL 2024-01-01

Abstract The RAS/RAF/MEK/ERK1/2 intracellular signaling pathway is activated by numerous cues during brain development and dysregulated in neurodevelopmental syndromes, particularly the RASopathies certain forms of autism. Cortical excitatory/inhibitory imbalance thought to be critical neuropathogenesis these conditions. However, developmental functions ERK1/2 cortical inhibitory neurons (CINs) other medial ganglionic eminence (MGE)-derived non-neuronal cells are poorly understood. Here, we...

10.1101/2022.08.02.502073 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2022-08-04
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