A5085335070- Amphibian and Reptile Biology
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Aquatic life and conservation
- Ichthyology and Marine Biology
- Cancer Genomics and Diagnostics
- Species Distribution and Climate Change
- Turtle Biology and Conservation
- Congenital limb and hand anomalies
- Bat Biology and Ecology Studies
- Identification and Quantification in Food
- RNA Research and Splicing
- Spider Taxonomy and Behavior Studies
- Aquaculture Nutrition and Growth
- Developmental Biology and Gene Regulation
- Cancer Cells and Metastasis
- Melanoma and MAPK Pathways
- Chromosomal and Genetic Variations
- Single-cell and spatial transcriptomics
- Cutaneous Melanoma Detection and Management
- Muscle Physiology and Disorders
- Fish biology, ecology, and behavior
- Evolution and Genetic Dynamics
- Paleontology and Evolutionary Biology
- Zoonotic diseases and public health
Oregon Health & Science University
2018-2023
Shriners Hospitals for Children - Portland
2023
University of Oregon
2015-2021
University of Kansas
2011-2015
Natural History Museum
2012
Speciation genomic studies aim to interpret patterns of genome-wide variation in light the processes that give rise new species. However, interpreting "landscape" speciation is difficult, because many evolutionary can impact levels variation. Facilitated by first chromosome-level assembly for group, we use whole-genome sequencing and simulations shed on have shaped landscape during a radiation monkeyflowers. After inferring phylogenetic relationships among 9 taxa this radiation, show highly...
Evolutionary origins of derived morphologies ultimately stem from changes in protein structure, gene regulation, and content. A well-assembled, annotated reference genome is a central resource for pursuing these molecular phenomena underlying phenotypic evolution. We explored the Gulf pipefish (Syngnathus scovelli), which belongs to family Syngnathidae (pipefishes, seahorses, seadragons). These fishes have dramatically bodies remarkable novelty among vertebrates, male brood pouch. produce...
We investigated diversity in the Amolops marmoratus species complex within Myanmar using both molecular and morphological characters from recently collected specimens. Based on congruence between multivariate analyses of quantitative phylogenetic nucleotide variation 16S ribosomal gene conducted 43 out 182 frogs examined, we recognize A. for specimens states Mon Shan northern Tanintharyi Division designate a neotype this species; resurrect afghanus (Günther, 1858) synonymy with state Kachin...
The structure of the caudal skeleton extant teleost fishes has been interpreted in two different ways. In a diural interpretation, is composed centra articulated with one to six hypurals. Most subsequent authors have followed this interpretation. contrast, polyural interpretation considers fin be derived from fully metameristic ancestral bauplan originally one-to-one relationship between neural arches, (when present), and Three interpretations identity homology skeletal components fish Danio...
The current standard for investigating tumors is surgical biopsy, which costly, invasive, and difficult to perform serially. As an adjunct, circulating tumor cells (CTCs)-cells that have broken away from the primary or metastatic sites-can be obtained a blood draw offer potential obtaining serial genetic information serving as biomarkers. Here, we detail melanoma CTCs serve biomarkers discuss clinically viable methodology single-cell CTC isolation analysis overcomes previous limitations. We...
With robust new datasets from morphology and DNA sequences, we review the limbed, nonpentadactyl species of Brachymeles samarensis complex (now known to include B. cebuensis, minimus, lukbani), describe five in this highly limb-reduced, endemic Philippine clade scincid lizards. For more than four decades, has been recognized as a single "widespread" species. This perception species' peculiar geographic range persisted result weak sampling similar gross (body sizes, scale pigmentation) among...
We describe a distinctively patterned new species of cascade stream frog from the mountains Nueva Vizcaya and Aurora provinces, Luzon Island. The belongs to genus Sanguirana, definition which we expand include all Philippine previously referred Rana (Hylarana) everetti complex. is distinguished other members by its possession bright yellow-green dorsum with conspicuous orange flower-shaped spots in females, white, postaxial dermal flanges on limbs, green-to-purple flank transition, highly...
Abstract Speciation genomic studies aim to interpret patterns of genome-wide variation in light the processes that give rise new species. However, interpreting ‘landscape’ speciation is difficult, because many evolutionary can impact levels variation. Facilitated by first chromosome-level assembly for group, we use whole-genome sequencing and simulations shed on have shaped landscape during a recent radiation monkeyflowers. After inferring phylogenetic relationships among nine taxa this...
In vitro models allow for the study of developmental processes outside embryo. To gain access to cells mediating digit and joint development, we identified a unique property undifferentiated mesenchyme isolated from distal early autopod autonomously re-assemble forming multiple structures including: digits, interdigital tissues, joints, muscles tendons. Single-cell transcriptomic analysis these developing revealed distinct cell clusters that express canonical markers limb development Col2a1...
Here, we present a rare case of patient who developed multiple primary melanomas within the boundaries two nevi depigmentosa. The were excised, and as preventive measure, remainder depigmentosa removed. We performed whole-exome sequencing on excised tissue from nevus depigmentosus, adjacent normal skin, saliva to explain this intriguing phenomenon. also GeneTrails Comprehensive Solid Tumor Panel analysis one melanoma tissues. Genetic revealed germline MC1R V92M TYR R402Q polymorphisms MET...