A5043115500- Health disparities and outcomes
- Health, Nursing, Elderly Care
- Nutrition and Health in Aging
- Frailty in Older Adults
- Global Health Care Issues
- Genetic Associations and Epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Dental Health and Care Utilization
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Health and Wellbeing Research
- T-cell and B-cell Immunology
- Child Nutrition and Water Access
- Vaccine Coverage and Hesitancy
- Pelvic floor disorders treatments
- Healthcare Systems and Reforms
- Musculoskeletal pain and rehabilitation
- Balance, Gait, and Falls Prevention
- Aging and Gerontology Research
- Influenza Virus Research Studies
- Global Public Health Policies and Epidemiology
- Dementia and Cognitive Impairment Research
- Cancer Genomics and Diagnostics
Universidade de São Paulo
2016-2025
Universidade Brasil
2008-2025
Instituto de Saúde
2019-2021
Blücher (Germany)
2020
Universidade de Ribeirão Preto
2020
Associação Saúde da Família
2020
Hospital Municipal Souza Aguiar
2020
Universidade Federal de Santa Maria
2020
Hospital Israelita Albert Einstein
2020
Escola Superior de Enfermagem de Lisboa
2019
Brazilians are highly admixed with ancestry from Europe, Africa, America, and Asia yet still underrepresented in genomic databanks. We hereby present a collection of exomic variants 609 elderly census-based cohort (SABE609) comprehensive phenotyping. Variants were deposited ABraOM (Online Archive Brazilian Mutations), Web-based public database. Population representative phenotype genotype repositories essential for variant interpretation through allele frequency filtering; since individuals...
Abstract As whole-genome sequencing (WGS) becomes the gold standard tool for studying population genomics and medical applications, data on diverse non-European admixed individuals are still scarce. Here, we present a high-coverage WGS dataset of 1,171 highly elderly Brazilians from census-based cohort, providing over 76 million variants, which ~2 absent large public databases. enables identification ~2,000 previously undescribed mobile element insertions without previous description, nearly...
OBJETIVO: Analisar os fatores relacionados à determinação e às desigualdades no acesso uso dos serviços de saúde por idosos. MÉTODOS: Estudo integrante do Projeto Saúde, Bem-estar Envelhecimento (SABE), qual foram entrevistados 2.143 indivíduos com 60 anos ou mais município São Paulo, SP, em 2000. A amostra foi obtida dois estágios, utilizando-se setores censitários reposição, probabilidade proporcional população complementação da pessoas 75 anos. Foi mensurado o hospitalares ambulatoriais...
The scope of this study was to analyze the difference in prevalence cardiovascular disease (CVD) between 2000 and 2010 its association with socio-economic risk factors among elderly. Bayesian multilevel models were applied CVD, individual characteristics presence CVD analyzed by logistic regression complex samples separately for 2000, 2006 2010. This research is part Health, Welfare Aging (SABE) study, performed Sao Paulo, Brazil, used collected An increase elderly observed during period,...
To investigate the prevalence of urinary incontinence among elderly people living in São Paulo, Brazil and their associated risk factors. The Pan-American Health Organization World coordinated a multicenter study named Health, Wellbeing Aging (SABE Study) (over 60 years old) seven countries Latin America Caribbean. In Brazil, was carried out Paulo year 2000. total Brazilian sample included 2,143 people. self reported 11.8% men 26.2% for women. It verified that those reporting incontinence,...
O objetivo foi identificar a prevalência, as características e associação da dor crônica com capacidade funcional. Estudo transversal amostra populacional feito por entrevista domiciliar idosos residentes na cidade de São Paulo, Brasil. Dor aquela duração mínima seis meses. Nas análises estatísticas utilizou-se teste RaoScott significância p < 0,05. ocorreu em 29,7% dos (IC95%: 25,4-33,9); os locais mais frequentes foram região lombar (25,4%) membros inferiores (21,9%) moderada 45,8% das...
Genetic evaluation has been recognized as an important tool to elucidate the causes of growth disorders. To investigate cause short stature and determine phenotype patients with IHH mutations, including response recombinant human hormone (rhGH) therapy. We studied 17 families autosomal-dominant by using whole exome sequencing screened defects in 290 Molecular analyses were performed evaluate potential impact N-terminal variants. identified 10 pathogenic or possibly variants IHH, regulator...
To investigate the prevalence of demand and provision care for Brazilian population with functional disabilities in activities daily living.This is a quantitative descriptive study using baseline data from ELSI-Brazil (Brazilian Longitudinal Study Aging), cohort representative sample aged 50 years or older (n = 9,412). We considered self-report having some difficulty to perform at least one activity life (eating, bathing, going toilet, dressing, moving room [ambulation], transferring chair...
The risk factors for diseases and premature deaths are important in drawing up preventive measures. This study had the aim of analyzing death among elderly people.This was carried out participants SABE (Health, Wellbeing Aging) study, city São Paulo 2000. Interviews were conducted with 2,143 people (60 years old or over), using a standardized questionnaire study. sample obtained from census tracts, two stages, replacements probability proportional to population, supplementation aged 75 over....
Although a reduced glomerular filtration rate (GFR) in old people has been attributed to physiologic aging, it may be associated with kidney disease or superimposed comorbidities. This study aims assess the prevalence of decreased GFR geriatric population developing country and its absence simultaneous diseases.This is cross-sectional data from Saúde, Bem-Estar e Envelhecimento cohort (SABE study[Health, Well-Being Aging]), multiple cohorts study. A multistage cluster sample composed 1,253...
The changes that occur during aging are accompanied by limitations in functional performance impair elderly people's social participation and consequently harm their quality of life. In the SABE Study (São Paulo, Brazil), results indicated relationships between life expectancy without disabilities demographic variables. This article sought to evaluate these other variables together as explanatory factors for presence or absence difficulties instrumental activities daily living (IADL),...
Accurate interpretation of germline mutations the rearranged during transfection (RET) proto-oncogene is vital for proper recommendation preventive thyroidectomy in medullary thyroid carcinoma (MTC)-prone carriers. To gain information regarding most disputed variant RET, ATA-A Y791F, we sequenced blood DNA samples from a cohort 2904 cancer-free elderly individuals (1261 via Sanger sequencing and 1643 whole-exome/genome sequencing). We also accessed exome sequences an additional 8069...
There is little epidemiological evidence demonstrating that dynapenic abdominal obesity has higher mortality risk than dynapenia and alone. Our main aim was to investigate whether combined with increases among English Brazilian older adults over ten-year follow-up.
Vision and hearing impairments can reduce participation in social activities. Given the prominent role of mouth face-to-face interactions, this study evaluated associations tooth loss, vision, with among older adults.This analysis included 1947 participants, aged 60+ years, who participated three waves (2006, 2010, 2015) Health, Wellbeing Aging Study (SABE) Brazil. Social was measured by number formal informal activities (requiring interaction) participants were regularly involved in. Teeth...
This study aimed to estimate coverage and identify factors associated vaccination against influenza in the elderly population.The design was cross-sectional population based. Data collected 2010 by Health, Well-Being Aging Study. Sample consisted of 1,341 community-dwelling elderly, São Paulo, Brazil. Association between covariates evaluated means prevalence ratios estimated Poisson regression models.Self-reported 74.2% (95% confidence interval: 71.3-76.9). Remaining physically active having...
Objective: To analyze gender differences in incidence and determinants of the components frailty phenotype. Method: A total 1,413 older adults were selected 2006. estimate each component, only individuals who did not exhibit a given component at baseline (independently presence other components) included study. The variables interest socioeconomic, behavioral, clinical, anthropometric factors physical performance. 2010 was outcome. Results: Unintentional weight loss slowness more incident...
Resumo Objetivou-se identificar a prevalência da violência doméstica contra idosos não institucionalizados e verificar se esta é um fator independente associado aos Componentes Físico (CF) Mental (CM) Qualidade de Vida Relacionada à Saúde (QVRS) desses idosos. É estudo epidemiológico transversal base populacional integrante do Estudo SABE (Saúde, Bem-Estar Envelhecimento). A amostra foi 1.126 que responderam ao Short-Form 12 Health Related Survey (SF-12), instrumento genérico avalia QVRS em...
HLA‐B is among the most variable gene in human genome. This encodes a key molecule for antigen presentation to CD8+ T lymphocytes and NK cell modulation. Despite myriad of studies evaluating its coding region (with an emphasis on exons 2 3), few evaluated introns regulatory sequences real population samples. Thus, variability probably underestimated. We applied bioinformatics pipeline tailored HLA genes 5347 samples from 80 different populations, which includes more than 1000 admixed...
Abstract Aim Some elderly patients with incontinence require the care of third parties, known as caregivers. Such can occur on a daily basis leaving little opportunity for caregiver to take himself/herself. The aims are assess association between urinary in and burden identify independent factors caregiver's city Sao Paulo, Brazil. Methods Pan‐American Health Organization World coordinated multicenter study named Health, Wellbeing Aging (SABE Study) people living seven countries Latin...
The majority of studies on the effects adiposity mortality in elderly have been conducted developed countries with mixed results. We investigated association between and a cohort community-dwelling Sao Paulo, Brazil.Body mass index (BMI), waist circumference, waist-to-hip ratio, type 2 diabetes were evaluated 1,882 participants (mean age 71.0 ± 8.3 years old, 61% female). Mortality was confirmed by national vital statistics records during maximum 10 follow-up. Proportional hazards models...
To analyze similarities among factors associated with the components of frailty in elderly.We studied 1,413 elderly from second wave SABE Study 2006. Each five phenotype was considered a dependent variable hierarchical logistic regression models.In both genders, age, schooling, sedentary lifestyle, and screening positive for depression were similarly more than one component frailty. Other also observed stroke cognitive decline men, number diseases gait speed women. The most similar...
Objective To date, no evidence of robust genotype–phenotype correlation or disease modifiers for multiple endocrine neoplasia type 1 (MEN1) syndrome has been described, leaving the highly variable clinical presentation patients unaccounted for. Design As CDKN1B ( p27 ) gene causes MEN4 and it is transcriptionally regulated by product MEN1 (menin), we sought to analyze whether influences phenotype -mutated patients. The cohort consisted 100 carrying germline mutations 855 population-matched...