A5040849276- Muscle and Compartmental Disorders
- Marine Bivalve and Aquaculture Studies
- Restraint-Related Deaths
- Marine and fisheries research
- Aquaculture Nutrition and Growth
- Virus-based gene therapy research
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Animal Virus Infections Studies
- IL-33, ST2, and ILC Pathways
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Epigenetics and DNA Methylation
- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Viral gastroenteritis research and epidemiology
National Institute of Allergy and Infectious Diseases
2022-2024
National Institutes of Health
2023-2024
University of Maryland Center for Environmental Science
2017-2021
Universidad de Los Lagos
2017
Abstract How macrophages in the tissue environment integrate multiple stimuli depends on genetic background of host, but this is still poorly understood. We investigate IL-4 activation male C57BL/6 and BALB/c strain specific vivo tissue-resident (TRMs) from peritoneal cavity. TRMs are more transcriptionally responsive to stimulation, with induced genes associated super enhancers, topologically associating domains (TAD) boundaries. IL-4-directed epigenomic remodeling reveals enrichment NF-κB,...
The release of captive-bred plants and animals has increased worldwide to augment declining species. However, insufficient attention been given understanding how neutral adaptive genetic variation are partitioned within among proximal natural populations, the patterns drivers gene flow over small spatial scales, which can be important for restoration success. A seascape genomics approach was used investigate population structure, local adaptation, extent environmental gradients influence...
Abstract Background Clarkson disease (monoclonal gammopathy-associated idiopathic systemic capillary leak syndrome, ISCLS) is a rare condition marked by transient, relapsing-remitting episodes of microvascular hyper-permeability, which liberates plasma fluid and macromolecules into the peripheral tissues. This pathology manifests clinically as abrupt onset hypotensive shock, hemoconcentration, hypoalbuminemia. Methods We analysed endothelial glycocalyx (eGCX)-related markers in from patients...
ABSTRACT Vaccinia virus (VACV) infection induces prominent changes in host cell metabolism. Little is known about the global metabolic reprogramming that takes place whole tissue during viral infection. Here, we performed a longitudinal metabolomics study VACV-infected mouse skin to investigate We assessed metabolites homogenized of ear pinnae over time presence or absence antigen-specific T cells using untargeted mass spectrometry. VACV induced several significant tissue, including levels...
How macrophages in the tissue environment integrate multiple stimuli will depend on genetic background of host, but this is poorly understood. Here, we investigated C57BL/6 and BALB/c strain specific
ABSTRACT Noroviruses are a major agent of acute gastroenteritis in humans, but host cell requirements for efficient replication vitro have not been established. We engineered human intestinal line (designated mCD300lf-hCaco2) expressing the murine norovirus (MNV) receptor, mouse CD300lf to become fully permissive MNV replication. To explore replicative machinery and response these cells, we performed single-cell RNA sequencing (scRNA-seq) transcriptomics analysis an infection over time....