Melanie Ambler

ORCID: 0000-0003-3963-2657
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About
Contact & Profiles
Research Areas
  • Family and Patient Care in Intensive Care Units
  • Intensive Care Unit Cognitive Disorders
  • Music Therapy and Health
  • Grief, Bereavement, and Mental Health
  • Memory and Neural Mechanisms
  • Palliative Care and End-of-Life Issues
  • Alcoholism and Thiamine Deficiency
  • Health, Medicine and Society
  • Cerebrospinal fluid and hydrocephalus
  • Long-Term Effects of COVID-19
  • Genomics and Rare Diseases
  • Tracheal and airway disorders
  • Alzheimer's disease research and treatments
  • Nuclear Structure and Function
  • Mitochondrial Function and Pathology
  • Neuroscience and Music Perception
  • Hearing Loss and Rehabilitation
  • Nausea and vomiting management
  • Airway Management and Intubation Techniques
  • Posttraumatic Stress Disorder Research
  • Metabolism and Genetic Disorders
  • COVID-19 and Mental Health
  • Retinoids in leukemia and cellular processes
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Epilepsy research and treatment

École Pratique des Hautes Études
2022-2023

Centre Hospitalier Universitaire de Caen Normandie
2022-2023

Inserm
2022-2023

Université de Caen Normandie
2022-2023

Université Paris Sciences et Lettres
2022-2023

Normandie Université
2022-2023

Cyceron
2022-2023

Neuropsychologie et Imagerie de la Mémoire Humaine
2022-2023

Stanford University
2022-2023

Columbia University
2021-2022

The psychological symptoms associated with having a family member admitted to the intensive care unit (ICU) during COVID-19 pandemic are not well defined.To examine prevalence of stress-related disorders, primarily posttraumatic stress disorder (PTSD), in members patients ICU approximately 90 days after admission.This prospective, multisite, mixed-methods observational cohort study assessed 330 (except New York City, which had random sample 25% all per month) between February 1 and July 31,...

10.1001/jamainternmed.2022.1118 article EN JAMA Internal Medicine 2022-04-25

This is the first observation of two cases symmetrical infantile thalamic degeneration with cell mineralisation in a family. Although it cannot be established at present, autosomal recessive inheritance metabolic error causing or predisposing to damage specific areas central nervous system possible aetiology for this condition.

10.1136/jmg.18.6.448 article EN Journal of Medical Genetics 1981-12-01

Rationale: Family members of critically ill patients with coronavirus disease (COVID-19) have described increased symptoms posttraumatic stress disorder (PTSD). Little is known about how these may change over time. Objectives: We studied changes in PTSD family COVID-19 12 months. Methods: This prospective, multisite observational cohort study recruited participants at hospitals five states. Calls were made to 3–4 months, 6 and months after patient admission the intensive care unit. Results:...

10.1513/annalsats.202209-793oc article EN cc-by-nc-nd Annals of the American Thoracic Society 2022-12-12

Background: Alzheimer’s disease (AD) and Korsakoff’s syndrome (KS) are two major neurocognitive disorders characterized by amnesia but AD is degenerative while KS not. The objective to compare regional volume deficits within the Papez circuit in KS, considering progression. Methods: 18 patients, 40 patients (20 with Moderate (MAD) matched on global cognitive 20 Severe (SAD)), 70 healthy controls underwent structural MRI. Volumes of hippocampi, thalami, cingulate gyri, mammillary bodies (MB)...

10.3390/jcm12093147 article EN Journal of Clinical Medicine 2023-04-27

Abstract Various etiologies for hypertension in Turner's syndrome, a common feature of the disorder, are well recognized. Pheochromocytoma is not among them. A young woman with recently diagnosed hypertension, died suddenly and unexpectedly. hemorrhagic cerebral infarct an adrenal gland pheochromocytoma were found at necropsy. This first reported case associated syndrome.

10.1520/jfs12597j article EN Journal of Forensic Sciences 1988-11-01

"This patient with COVID has been sick for several weeks and is not doing well. He's paralyzed sedated on the ventilator. His son having a hard time this likes idea of you playing music his dad." I feel weight opportunity dial into room.

10.1503/cmaj.201662 article EN cc-by-nc-nd Canadian Medical Association Journal 2020-11-01

The COVID-19 pandemic presented unprecedented challenges to patients, family members, and healthcare staff that resulted in increased stress isolation decreased quality of life. We evaluate the impact a novel virtual concert program, Vital Sounds Initiative (VSI) Project: Music Heals Us (PMHU), which began at beginning combat patient provide employment professional musicians. Using qualitative analysis VSI data, we examined post-concert written responses by These were coded independent...

10.3390/healthcare11222929 article EN Healthcare 2023-11-09

ABSTRACT Objectives To compare regional volume deficits within the Papez circuit in Alzheimer’s disease (AD) and Korsakoff’s syndrome (KS), taking into account neurodegenerative nature of AD. Methods 18 KS patients, 40 AD patients (20 with Moderate (MAD) matched on cognitive deterioration 20 Severe (SAD)), 70 healthy controls underwent structural MRI examination. Volumes hippocampi, thalami, cingulate gyri, mammillary bodies (MB) mammillothalamic tracts (MTT) were extracted. Results For...

10.1101/2022.10.28.22281661 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2022-10-30

« Ce patient atteint de la COVID-19 est malade depuis plusieurs semaines et ne va pas bien. Il paralysé, sous sédatif ventilation. Son fils souffre cette situation aimerait que vous jouiez musique pour son père. » Je ressens le poids demande, je me connecte

10.1503/cmaj.201662-f article FR cc-by-nc-nd Canadian Medical Association Journal 2021-01-17

RATIONALE: Currently, there are over 20,000 COVID-19 positive patients requiring intensive care unit (ICU) in the United States (US). Even prior to pandemic, up 30% of family members ICU experience post-traumatic stress disorder and 50% sustain potentially prolonged anxiety and/or depression. Although bedside engagement improves both short-and long-term outcomes for their families, nationwide social distancing recommendations have curtailed hospital visitation, heightening risk...

10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1209 article EN 2021-05-01

Introduction: Before the COVID-19 pandemic, 20-30% of family members had symptoms Post-Traumatic Stress Disorder (PTSD) or anxiety, while 15-30% depression. Interventions supporting have reduced burden these symptoms. has resulted in prolonged ICU stays, high morbidity/mortality, and hospital policies severely limiting presence at bedside. We hypothesized combination critical illness necessary reduction would lead to rates PTSD, depression;likely higher than observed previous studies....

10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1497 article EN 2021-05-01
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