Abstract Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common potentially lethal clinical syndromes characterized by failure resulting from excessive pulmonary inflammation, noncardiogenic edema, alveolar–capillary barrier disruption. At present, there is no effective specific therapy for ALI/ARDS. Mesenchymal stem cells (MSCs) have well‐known therapeutic potential in patients with Heme oxygenase‐1 (HO‐1), a cytoprotective enzyme, possesses antioxidative,...

Abstract Background Human periodontal ligament fibroblasts (HPDLFs) represent the first line of defense against pathogens in tissue. Porphyromonas gingivialis ( P. gingivalis ) has been known to be most strongly associated with periodontitis. MicroRNA (miR)‐146a is involved inflammatory regulation However, regulatory mechanism miR‐146a on ‐induced inflammation response HPDLFs was still unclear. The aim this study investigate whether plays a key role gingvalis responses through TRAF6 HPDLFs....

Objective: To investigate the effects of laser-treated enamel surface roughness on adhesion Streptococcus mutans. Methods: A total 176 premolars extracted for subtractive orthodontic treatment were collected. Samples randomly divided into four groups: control group, 35% phosphoric acid, Er:YAG laser, Er,Cr:YSGG laser. Surface was detected using three-dimensional white light interferometric topography (n = 8/group), and morphology observed by scanning electron microscope [(SEM), n 8/group]....

Alveolar macrophages (AMs) are the first line of defense against foreign stimulation in alveoli, and they participate inflammatory responses during acute lung injury (ALI). Previous studies indicated that paralemmin-3 (PALM3) expression is induced by lipopolysaccharides (LPS) may be involved LPS-Toll-like receptor 4 (TLR4) signaling alveolar epithelial cells. The aim present study was to investigate effect PALM3 on LPS-induced inflammation its underlying mechanisms rat AMs. For this purpose,...

Acute lung injury (ALI) is a common, costly and potentially lethal disease with characteristics of alveolar‑capillary membrane disruption, pulmonary edema impaired gas exchange due to increased apoptosis inflammation. There no effective specific therapy for ALI; however, mesenchymal stem cells (MSCs) have been demonstrated be potential option. Lipopolysaccharide (LPS) highly proinflammatory molecule that used mimic an in vivo inflammatory damaged state vitro. The present study investigated...

ABSTRACT Tumor necrosis factor alpha (TNFα) plays a key role in the pathogenesis of rheumatoid arthritis (RA). Blockade TNFα by monoclonal antibody has been widely used for therapy RA since 1990s; however, its mechanism efficacy, and potential safety concerns treatment are still not fully understood. This study sought to establish transgenic arthritic mouse model overexpressing human (hTNFα) apply this as means evaluate therapeutic consequences inhibitors. The line (TgTC) with FVB background...

Objective: This study sought to compare enamel surface morphology and orthodontic bracket re-bonding strength after phosphoric acid- or erbium-doped yttrium aluminum garnet (Er:YAG) laser-mediated re-etching. Methods: A total of 81 extracted premolars were obtained from patients undergoing procedures. Conventional etching with 35% acid was first used bond brackets the surface. Then de-bonded 1 week later. These samples then separated randomly into three groups (n = 27 teeth each group)...

Aim: To investigate the expression levels of receptor activator NF-κB ligand (RANKL) and oste-oprotegerin (OPG) in human periodontal ligament fibroblasts when stimulated with heat infective conditions. Methods: Periodontal were subjected to various temperature increases for 5 min or without 10 ng/mL lipopolysaccharide (LPS) then maintained at 37℃ 6 h. After that, RANKL OPG investigated using real-time RT-PCR ELISA. As a positive negative control, cells cultured LPS. Data analyzed one-way...

The effect of different hydroxyapatite particles on malignant melanoma cell was evaluated in vitro. Two kinds short-rode particles, which range from 0.4 to 1 um and 0.5 1.5 um, were co-cultured with human’s (MM) line A375 for 24, 48, 72 h. Both these HA showed the same proliferation rate as blank control, there no statistically significant correlation matrix metalloproteinases-2 (MMP-2) expression particle size. SEM images that membrane tumor cell, shrunk. superficial sentus reduced small...

Background: The transplantation of bone marrow mesenchymal cells (BMSCs) has been shown to be an effective mean for treating sepsis-related organ damage. Pytoptotic cell death, in turn, recently identified as a key driver At present, there are few studies on the effect BMSC pyroptotic death. Objective: We explored ability BMSCs attenuate hepatic damage pyroptosis-related manner rat model lipopolysaccharide (LPS)-induced liver injury. Methods: Following injury modeling and transplantation, we...

Objective To investigate the expression of C/EBP homology protein(CHOP) in rat brain tissue after focal cerebral ischemia-reperfusion,as well as to observe influence shenxiong injection on CHOP.Methods One hundred forty four male rats were randomly divided into three groups:the sham-operation group,operation group,shenxiong group.Focal ischemia and reperfusion models established by using suture.Zea Longa method was introduced evaluate neurologic behavioral changes.The levels mRNA protein...