A5047443167- DNA and Nucleic Acid Chemistry
- DNA Repair Mechanisms
- Biopolymer Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Synthesis and Characterization of Heterocyclic Compounds
- HIV/AIDS drug development and treatment
- Monoclonal and Polyclonal Antibodies Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bacteriophages and microbial interactions
- Amino Acid Enzymes and Metabolism
- Chemical Synthesis and Analysis
- Coenzyme Q10 studies and effects
- ATP Synthase and ATPases Research
- Cytomegalovirus and herpesvirus research
- Organophosphorus compounds synthesis
- Fungal and yeast genetics research
- Click Chemistry and Applications
- Pediatric health and respiratory diseases
- Chemical and Physical Studies
- Electron Spin Resonance Studies
- Insect symbiosis and bacterial influences
- Insect and Pesticide Research
- Inhalation and Respiratory Drug Delivery
- Radiopharmaceutical Chemistry and Applications
- Acute Lymphoblastic Leukemia research
Moscow State University
2011-2023
Lomonosov Moscow State University
2005-2023
Institute of Bioorganic Chemistry
1998-1999
Russian Academy of Sciences
1996
New polyanionic modifications of polyamide nucleic acid mimics were obtained. Thymine decamers synthesized from respective chiral α- and γ-monomers, their enantiomeric purity was assessed. Here, we present the decamer synthesis, purification characterization by MALDI-TOF mass spectrometry an investigation hybridization properties decamers. We show that modified γ-S-carboxyethyl-T10 PNA forms a stable triplex with polyadenine DNA.
Abstract Regioselective method for 1-β-D-glucopyranosylthymine incorporation into oligonucleotides has been developed and substrate properties of the latters in DNA synthesis hydrolysis reactions were investigated.
Inorganic polyphosphates (polyP), according to literature data, are involved in the regulatory processes of molecular complex Saccharomyces cerevisiae cell wall (CW). The aim work was reveal relationship between polyP, acid phosphatase Pho3p, and major CW protein, glucanosyl transglycosylase Bgl2p, which is main glucan-remodelling enzyme with amyloid properties. It has been shown that yeast cells deletion PHO3 gene contain more high alkali-soluble polyP also resistant exposure alkali...
Abstract A method of completely chemical synthesis 3′-azido-3′-deoxythymidine-terminated oligonucleotides via 5′-H-phosphonate AZT is described.
The study is devoted to 8-oxo-2'-deoxyguanosine (8-oxo-dG), which used as a biomarker of oxidative damage DNA and its associated diseases. based on the hypothesis put forward by authors about ability 8-oxo-dG, main product oxidation, act signal molecule that activates cell resistance nonspecific stress repair. In addition studying molecular mechanisms action have carried out an investigation effects they caused organism level.
Abstract An oligodeoxynucleotide bearing a 3′-terminal perylene-containing pseudonucleoside unit was synthesized and used as probe in homogeneous hybridization. The fluorescence anisotropy of the perylene dye rose upon hybridization modified conjugate with complementary nucleotide sequence. These results provide for designing efficacious probes.
The changes of the 8-oxo-2'-deoxyguanosine (8-oxo-dG)/dG ratio in DNA laboratory mice hepatocytes under influence toxic stress were studied. It was shown that injection carbon tetrachloride causes growth 8-oxo-dG level. A rapid increase level occurs during first day experiment at short-term stress. Subsequently, 48 hours after initial injection, decreases to control values. This change value biomarker can be attributed activation reparative and antioxidant systems. subsequent results again...