A5043122426- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Biosensors and Analytical Detection
- Respiratory viral infections research
- Influenza Virus Research Studies
- COVID-19 and Mental Health
- Infection Control and Ventilation
- COVID-19 and healthcare impacts
- Healthcare cost, quality, practices
- Sleep and related disorders
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Ethics in medical practice
- Palliative Care and End-of-Life Issues
- Viral Infections and Vectors
- COVID-19 Pandemic Impacts
- Monoclonal and Polyclonal Antibodies Research
- Clinical practice guidelines implementation
- Health Systems, Economic Evaluations, Quality of Life
- Immunotherapy and Immune Responses
- Urinary Tract Infections Management
- Virology and Viral Diseases
- Animal Disease Management and Epidemiology
- Long-Term Effects of COVID-19
Universitätsklinikum Würzburg
2022-2025
University of Würzburg
2021-2025
Gold Coast Hospital
2024
Victoria Park
2024
Antigen rapid diagnostic tests (RDT) for SARS-CoV-2 are fast, broadly available, and inexpensive. Despite this, reliable clinical performance data from large field studies is sparse.In a prospective evaluation study, RDT three manufacturers (NADAL®, Panbio™, MEDsan®, conducted on different samples) were compared to quantitative reverse transcription polymerase chain reaction (RT-qPCR) in 5 068 oropharyngeal swabs detection of hospital setting. Viral load was derived standardised RT-qPCR...
Against the background of current COVID-19 infection dynamics with its rapid spread SARS-CoV-2 variants concern (VOC), immunity and vaccine prevention healthcare workers (HCWs) against continues to be high importance. This observational cross-section study assesses factors influencing level anti-SARS-CoV-2-spike IgG after or vaccination. One thousand seven hundred fifty HCWs were recruited meeting following inclusion criteria: age ≥18 years, PCR-confirmed convalescence and/or at least one...
Abstract Background Antigen rapid diagnostic tests (RDT) for SARS-CoV-2 are fast, broadly available, and inexpensive. Despite this, reliable clinical performance data is sparse. Methods In a prospective evaluation study, RDT from three manufacturers (NADAL®, Panbio™, MEDsan®) were compared to quantitative reverse transcription polymerase chain reaction (RT-qPCR) in 5 068 oropharyngeal swabs detection of hospital setting. Viral load was derived standardized RT-qPCR Cycle threshold (C t )...
Surveillance is an acknowledged method to decrease nosocomial infections, such as surgical site infections (SSIs). Electronic healthcare records create the opportunity for automated surveillance. While approaches different types of surgeries and indicators already exist, there are very few obstetrics gynaecology.
ABSTRACT Introduction During the COVID-19 pandemic, SARS-CoV-2 antigen rapid detection tests (RDTs) emerged as point-of-care diagnostics in addition to RT-qPCR gold standard for diagnostics. Facing course of pandemic an endemic characterised by several virus variants concern (VOC) and increasing public vaccination rate aim study was investigate long-term test performance RDT large-scale, clinical screening use during its influencing factors, above all VOC vaccination. Methods In a...
Abstract This longitudinal prospective controlled multicenter study aimed to monitor immunity generated by three exposures caused breakthrough infections (BTI) after COVID‐19‐vaccination considering pre‐existing cell‐mediated common‐corona‐viruses (CoV) which may impact cellular reactivity against SARS‐CoV‐2. Anti‐SARS‐CoV‐2‐spike‐IgG antibodies (anti‐S‐IgG) and Spike‐(S)‐ nucleocapsid‐(N)‐proteins were determined in fully‐vaccinated (F) individuals who either experienced BTI (F+BTI) or had...
Healthcare workers (HCWs) are recommended to receive at least three spike-antigen exposures generate basic immunity and mediate herd protection of vulnerable patients. So far, less attention has been put on the cellular immune response induced by homologous (three BTN162b2mRNA doses) or heterologous (mRNA-1273 as third dose building two BTN162bmRNA immunological impact breakthrough infections (BTIs). Therefore, in 356 vaccinated HCWs with without BTIs Anti-SARS-CoV-2-Spike-IgG concentrations...
Abstract Sleep modulates the immune response and sleep loss can reduce immunogenicity of certain vaccinations. Vice versa responses impact sleep. We aimed to investigate influence mental health quality on COVID-19 vaccinations and, conversely, quality. The prospective CoVacSer study monitored health, quality, Anti-SARS-CoV-2-Spike IgG titres in a cohort 1,082 healthcare workers from 29 th September 2021 19 December 2022. Questionnaires blood samples were collected before, 14 days, three...
Sleep modulates the immune response, and sleep loss can reduce vaccine immunogenicity; vice versa, responses impact sleep. We aimed to investigate influence of mental health quality on immunogenicity COVID-19 vaccinations and, conversely, quality. The prospective CoVacSer study monitored health, Anti-SARS-CoV-2-Spike IgG titres in a cohort 1082 healthcare workers from 29 September 2021 19 December 2022. Questionnaires blood samples were collected before, 14 days, 3 months after third...
Background: Antigen rapid diagnostic tests (RDT) for SARS-CoV-2 are quick, widely available, and inexpensive. Consequently, RDT have been established as an alternative additional strategy to quantitative reverse transcription polymerase chain reaction (RT-qPCR). However, reliable virus variant of concern (VOC) specific clinical large-scale performance data is limited, especially Omicron VOC.Methods: This single-centre prospective assessment compares from three manufacturers (NADAL®, Panbio™,...
ABSTRACT Background Against the background of current COVID-19 infection dynamics with rapid spread SARS-CoV-2 variants concern (VOC), above all Omicron VOC, immunity healthcare workers (HCWs) against continues to be high importance. Vaccination plays a central role in reducing severity and potentially disease. In healthcare, this is important prevent disease-related staff shortages. However, there lack data on factors influencing humoral immune response. Aim The aim our study was determine...
Abstract In the light of emerging SARS-CoV-2 variants concern (VOC), bivalent COVID-19 vaccines combining wild-type spike mRNA with an Omicron VOC BA.1 or BA.4-5 became available. This non-randomized controlled study examined adverse reactions, PRN ( pro re nata ) medication intake and inability to work after a fourth vaccination among 76 healthcare workers. As dose either original, monovalent BNT162b2mRNA (48.7%) original/Omicron vaccine (51.3%) was administered. The rate reactions for...
ABSTRACT Background A third dose of COVID-19 vaccination (‘COVID booster vaccination’) has become established as an important measure to strengthen the immune response against SARS-CoV-2. In contrast, seasonal influenza been infection prevention for years, especially among highly exposed healthcare workers (HCWs). Coadministration vaccines and could be efficient strategy protect HCWs from two major viral respiratory infections. Yet, immunogenicity safety coadministration remains evaluated....