A5088931955- Viral gastroenteritis research and epidemiology
- Pediatric health and respiratory diseases
- Clostridium difficile and Clostridium perfringens research
- IL-33, ST2, and ILC Pathways
- Child Nutrition and Water Access
- Tuberculosis Research and Epidemiology
- Infant Nutrition and Health
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Hepatitis Viruses Studies and Epidemiology
- Gut microbiota and health
- Animal Virus Infections Studies
- Mycobacterium research and diagnosis
- Diet, Metabolism, and Disease
- Pneumonia and Respiratory Infections
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Amoebic Infections and Treatments
- Learning Styles and Cognitive Differences
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
Qiagen (United States)
2021
University of Virginia Health System
2018
Georgia State University
2012-2014
Emory University
2014
Activators of innate immunity may have the potential to combat a broad range infectious agents. We report that treatment with bacterial flagellin prevented rotavirus (RV) infection in mice and cured chronically RV-infected mice. Protection was independent adaptive interferon (IFN, type I II) required receptors Toll-like receptor 5 (TLR5) NOD-like C4 (NLRC4). Flagellin-induced activation TLR5 on dendritic cells elicited production cytokine interleukin-22 (IL-22), which induced protective gene...
Background. Rotavirus causes 500 000 deaths and millions of physician visits hospitalizations per year, with worse outcomes reduced vaccine efficacy in developing countries. We hypothesized that the gut microbiota might modulate rotavirus infection and/or antibody response thus potentially play a role such regional differences. Methods. The was ablated via germ-free or antibiotic approaches. Enhanced exposure to achieved low-dose dextran sodium sulfate (DSS) treatment. replication assessed...
Chronically undernourished children become stunted during their first 2 years and thereafter bear burdens of ill health for the rest lives. Contributors to stunting include poor nutrition exposure pathogens, parental history may also play a role. However, epigenetic impact environment on young is largely unknown. Here we show unfolding pattern histone H3 lysine 4 trimethylation (H3K4me3) in mothers living an urban slum Dhaka, Bangladesh. A chromatin modification blood cells emerges over time...
Rotavirus (RV) infects small intestinal epithelial cells, inducing severe diarrhea in children, resulting over 500,000 deaths annually. Relatively little is known about how innate immunity contains acute infection and drives adaptive immune responses that afford complete clearance of RV protection against future infection. Hence, we examined the consequence absence MyD88, to be central immunity, a mouse model The but not combined blockade IL-1β IL-18 signaling, resulted greater infectivity,...
BACKGROUND: Programmatic management of TB infection is a critical component the WHO End Strategy. Interferon-gamma release assays (IGRAs) overcome some limitations tuberculin skin test, but implementation IGRA testing in low-resource settings challenging.METHODS: In this feasibility study, we evaluated performance novel digital lateral-flow assay, QIAreach® QuantiFERON® (QIAreach-QFT) against QuantiFERON®-TB Gold Plus (QFT-Plus) assay. A population with mix risk factors for (111 donors) were...
In 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic. Disease diagnosis, appropriate clinical management and infection control are all important factors in controlling the spread of SARS-CoV-2. The QIAreach™ Anti-SARS-CoV-2 Total Test (Anti-CoV2) is rapid, qualitative serological test, using proprietary nanoparticle fluorescence technology to detect total antibody (IgA, IgM, IgG) against Here we report results US Food Drug Administration (FDA)...